PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16570269-0	2006	Nicotine induces the fragile histidine triad methylation in human esophageal squamous epithelial cells.	Nicotine	0-8	fragile histidine triad diadenosine triphosphatase	Homo sapiens	21-44	
16570269-3	2006	In this study, we confirmed methylation of the FHIT gene in human esophageal squamous epithelial cells (HEECs) and examined whether nicotine induced alteration of FHIT.	Nicotine	132-140	fragile histidine triad diadenosine triphosphatase	Homo sapiens	163-167	
16570269-4	2006	Methylation status in the promoter region of the FHIT gene and p16(INK4A) gene was determined by methylation-specific PCR in HEECs exposed to nicotine under various conditions.	Nicotine	142-150	fragile histidine triad diadenosine triphosphatase	Homo sapiens	49-53	
16570269-8	2006	Nicotine induced the methylation of FHIT gene and attenuated Fhit protein in association with increased expression of DNMT3a.	Nicotine	0-8	fragile histidine triad diadenosine triphosphatase	Homo sapiens	36-40	
16570269-8	2006	Nicotine induced the methylation of FHIT gene and attenuated Fhit protein in association with increased expression of DNMT3a.	Nicotine	0-8	fragile histidine triad diadenosine triphosphatase	Homo sapiens	61-65	
16570269-9	2006	Reexpression of Fhit protein in HEECs was found after cessation of moderate- to long-term exposure to nicotine.	Nicotine	102-110	fragile histidine triad diadenosine triphosphatase	Homo sapiens	16-20	
16570269-10	2006	Our results show that nicotine induces methylation of the FHIT gene followed by loss of Fhit protein expression in HEECs.	Nicotine	22-30	fragile histidine triad diadenosine triphosphatase	Homo sapiens	58-62	
16570269-10	2006	Our results show that nicotine induces methylation of the FHIT gene followed by loss of Fhit protein expression in HEECs.	Nicotine	22-30	fragile histidine triad diadenosine triphosphatase	Homo sapiens	88-92