PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21899407-7 2011 Brain AChE activities after ethanol + nicotine treatments showed significantly less inhibition following repeated 5 mg CPF/kg dosing compared to CPF only (96 +- 13 and 66 +- 7% of naive at 4 h post last CPF dosing, respectively). Nicotine 38-46 acetylcholinesterase Rattus norvegicus 6-10 24854235-17 2014 The second study revealed that nicotine exposure increased AChE activity in the NAc to a greater extent in adolescent versus adult rats. Nicotine 31-39 acetylcholinesterase Rattus norvegicus 59-63 21116174-0 2011 Acetylcholinesterase inhibitors partially generalize to nicotine discriminative stimulus effect in rats. Nicotine 56-64 acetylcholinesterase Rattus norvegicus 0-20 17156201-10 2006 Nicotine-induced signals reflected the hydrolysis of ACh by endogenous acetylcholinesterase (AChE) as inhibition of the enzyme following perfusion with neostigmine (10 microm) attenuated the signal (40-94%). Nicotine 0-8 acetylcholinesterase Rattus norvegicus 71-91 20097188-8 2010 The extent of brain acetylcholinesterase (AChE) inhibition was reduced due to nicotine co-exposure consistent with an increase in CYP450-mediated dearylation (detoxification) versus desulfuration. Nicotine 78-86 acetylcholinesterase Rattus norvegicus 20-40 20097188-8 2010 The extent of brain acetylcholinesterase (AChE) inhibition was reduced due to nicotine co-exposure consistent with an increase in CYP450-mediated dearylation (detoxification) versus desulfuration. Nicotine 78-86 acetylcholinesterase Rattus norvegicus 42-46 20097188-13 2010 The current study demonstrated that repeated nicotine exposure could alter CPF metabolism in vivo, resulting in altered brain AChE inhibition. Nicotine 45-53 acetylcholinesterase Rattus norvegicus 126-130 16627857-4 2007 Neostigmine, an acetylcholinesterase inhibitor, mimicked the actions of nicotine. Nicotine 72-80 acetylcholinesterase Rattus norvegicus 16-36 17156201-10 2006 Nicotine-induced signals reflected the hydrolysis of ACh by endogenous acetylcholinesterase (AChE) as inhibition of the enzyme following perfusion with neostigmine (10 microm) attenuated the signal (40-94%). Nicotine 0-8 acetylcholinesterase Rattus norvegicus 93-97 16482470-10 2006 Brainstem and cerebellum of female offspring from mothers treated with nicotine or chlorpyrifos, alone or in combination showed increased AChE activity, whereas brainstem of male offspring from mothers treated with nicotine alone or a combination of nicotine and chlorpyrifos showed increase in AChE activity. Nicotine 71-79 acetylcholinesterase Rattus norvegicus 138-142 16482470-10 2006 Brainstem and cerebellum of female offspring from mothers treated with nicotine or chlorpyrifos, alone or in combination showed increased AChE activity, whereas brainstem of male offspring from mothers treated with nicotine alone or a combination of nicotine and chlorpyrifos showed increase in AChE activity. Nicotine 71-79 acetylcholinesterase Rattus norvegicus 295-299 16482470-11 2006 Also, male offspring exposed in utero to nicotine exhibited increased AChE activity. Nicotine 41-49 acetylcholinesterase Rattus norvegicus 70-74 16482470-14 2006 These results indicate that in utero exposure to nicotine and chlorpyrifos, alone and in combination produced significant sensorimotor deficits in male and female offspring, differential increase in brain AChE activity, a decrease in the surviving neurons and an increased expression of GFAP in cerebellum in adult offspring rats at a corresponding human adult age. Nicotine 49-57 acetylcholinesterase Rattus norvegicus 205-209 14555401-5 2003 On PND 7, there was a significant increase in brain acetylcholinesterase (AChE) activity in pups from nicotine- and chlorpyrifos-treated dams, whereas plasma butyrylcholinesterase (BChE) activity was significantly elevated in pups of mothers treated with either chlorpyrifos alone or pesticide combined with nicotine. Nicotine 102-110 acetylcholinesterase Rattus norvegicus 52-72 15045467-7 2004 Male offspring from mothers treated with either chlorpyrifos or nicotine alone showed a significant increase in the acetylcholinesterase (AChE) activity in the brainstem while female offspring from mothers treated with either nicotine or a combination of nicotine and chlorpyrifos showed a significant increase (approximately 134 and 126% of control, respectively) in AChE activity in the brainstem. Nicotine 64-72 acetylcholinesterase Rattus norvegicus 116-136 15045467-7 2004 Male offspring from mothers treated with either chlorpyrifos or nicotine alone showed a significant increase in the acetylcholinesterase (AChE) activity in the brainstem while female offspring from mothers treated with either nicotine or a combination of nicotine and chlorpyrifos showed a significant increase (approximately 134 and 126% of control, respectively) in AChE activity in the brainstem. Nicotine 64-72 acetylcholinesterase Rattus norvegicus 138-142 15045467-7 2004 Male offspring from mothers treated with either chlorpyrifos or nicotine alone showed a significant increase in the acetylcholinesterase (AChE) activity in the brainstem while female offspring from mothers treated with either nicotine or a combination of nicotine and chlorpyrifos showed a significant increase (approximately 134 and 126% of control, respectively) in AChE activity in the brainstem. Nicotine 64-72 acetylcholinesterase Rattus norvegicus 368-372 15045467-7 2004 Male offspring from mothers treated with either chlorpyrifos or nicotine alone showed a significant increase in the acetylcholinesterase (AChE) activity in the brainstem while female offspring from mothers treated with either nicotine or a combination of nicotine and chlorpyrifos showed a significant increase (approximately 134 and 126% of control, respectively) in AChE activity in the brainstem. Nicotine 226-234 acetylcholinesterase Rattus norvegicus 116-136 15045467-7 2004 Male offspring from mothers treated with either chlorpyrifos or nicotine alone showed a significant increase in the acetylcholinesterase (AChE) activity in the brainstem while female offspring from mothers treated with either nicotine or a combination of nicotine and chlorpyrifos showed a significant increase (approximately 134 and 126% of control, respectively) in AChE activity in the brainstem. Nicotine 226-234 acetylcholinesterase Rattus norvegicus 138-142 15045467-7 2004 Male offspring from mothers treated with either chlorpyrifos or nicotine alone showed a significant increase in the acetylcholinesterase (AChE) activity in the brainstem while female offspring from mothers treated with either nicotine or a combination of nicotine and chlorpyrifos showed a significant increase (approximately 134 and 126% of control, respectively) in AChE activity in the brainstem. Nicotine 226-234 acetylcholinesterase Rattus norvegicus 116-136 15045467-7 2004 Male offspring from mothers treated with either chlorpyrifos or nicotine alone showed a significant increase in the acetylcholinesterase (AChE) activity in the brainstem while female offspring from mothers treated with either nicotine or a combination of nicotine and chlorpyrifos showed a significant increase (approximately 134 and 126% of control, respectively) in AChE activity in the brainstem. Nicotine 226-234 acetylcholinesterase Rattus norvegicus 138-142 15045467-11 2004 These results suggest that maternal exposure to real-life levels of nicotine and/or chlorpyrifos causes differential regulation of brainstem AChE activity. Nicotine 68-76 acetylcholinesterase Rattus norvegicus 141-145 14555401-5 2003 On PND 7, there was a significant increase in brain acetylcholinesterase (AChE) activity in pups from nicotine- and chlorpyrifos-treated dams, whereas plasma butyrylcholinesterase (BChE) activity was significantly elevated in pups of mothers treated with either chlorpyrifos alone or pesticide combined with nicotine. Nicotine 102-110 acetylcholinesterase Rattus norvegicus 74-78 14555401-7 2003 In female pups on PND 30 there was a significant rise in AChE activity in brainstem of chlorpyrifos alone and in cerebellum of the combination nicotine and chlorpyrifos group. Nicotine 143-151 acetylcholinesterase Rattus norvegicus 57-61 14555401-10 2003 Data suggest that maternal exposure to nicotine and chlorpyrifos, alone or in combination, produces differential alterations in brain regional AChE activity and expression of GFAP in cerebellum and hippocampus in offspring on PND 30. Nicotine 39-47 acetylcholinesterase Rattus norvegicus 143-147 12937891-10 2003 Exposure to nicotine alone resulted in a significant increase in AChE activity in brainstem and midbrain, whereas there was no significant change after exposure to chlorpyrifos, alone. Nicotine 12-20 acetylcholinesterase Rattus norvegicus 65-69 3359327-2 1988 We now report that this transient AChE pattern is paralleled by a marked increase in [3H]nicotine binding sites in layer IV of area 17. Nicotine 89-97 acetylcholinesterase Rattus norvegicus 34-38 35182342-6 2022 Our findings revealed that nicotine treatment induced significant increases in the incidence of micronucleus, sperm abnormalities, and expression levels of AChE in addition to inducing histopathological changes in rat testis. Nicotine 27-35 acetylcholinesterase Rattus norvegicus 156-160 35182342-7 2022 On the other hand, administration of FS or NFS with nicotine significantly decreased the incidence of micronuclei and the percentage of sperm abnormalities as well as the expression levels of AChE gene. Nicotine 52-60 acetylcholinesterase Rattus norvegicus 192-196 7138238-2 1982 As compared with control it was established that combined MNNG and nicotine long-term administration led to the occurrences: 1) stomach pretumorous changes of the whole mucous membrane; 2) earlier development of stomach cancer tumors and its frequency was doubled; 3) progressive decrease of acetylcholinesterase activity, especially expressed in homogenates of cerebrum hemispheres, hypothalamic region and medulla oblongata (where this activity is practically failed to be expressed). Nicotine 67-75 acetylcholinesterase Rattus norvegicus 292-312 6875853-0 1983 [3H]Nicotine binding in rat brain: alteration after chronic acetylcholinesterase inhibition. Nicotine 4-12 acetylcholinesterase Rattus norvegicus 60-80 26563165-5 2016 In sham rats, the local application of nicotine and edrophonium (an acetylcholinesterase inhibitor) increases GP neurons spiking rate. Nicotine 39-47 acetylcholinesterase Rattus norvegicus 68-88 28350399-0 2017 Repeated administration of an acetylcholinesterase inhibitor attenuates nicotine taking in rats and smoking behavior in human smokers. Nicotine 72-80 acetylcholinesterase Rattus norvegicus 30-50 26784967-0 2016 Repeated administration of an acetylcholinesterase inhibitor attenuates nicotine taking in rats and smoking behavior in human smokers. Nicotine 72-80 acetylcholinesterase Rattus norvegicus 30-50 26784967-3 2016 Our previous studies demonstrated that acute administration of an acetylcholinesterase inhibitor (AChEI) attenuates nicotine taking and seeking in rats and suggest that AChEIs could be repurposed for smoking cessation. Nicotine 116-124 acetylcholinesterase Rattus norvegicus 66-86 26428579-0 2015 Nicotine inhibits hippocampal and striatal acetylcholinesterase activities, and demonstrates dual action on adult neuronal proliferation and maturation. Nicotine 0-8 acetylcholinesterase Rattus norvegicus 43-63 26428579-5 2015 RESULTS: There was significant decrease (P<0.001) in AChE positive cells in the hippocampus and striatum following 2 and 4mg/kg nicotine but not at 0.25mg/kg. Nicotine 131-139 acetylcholinesterase Rattus norvegicus 56-60 26428579-8 2015 CONCLUSION: This study suggests that nicotine may inhibit AChE activities in the brain, thereby having a direct or indirect influence on prevention of central acetylcholine degradation, as well as either improve or retard maturation adult born neurons in DG, at different doses. Nicotine 37-45 acetylcholinesterase Rattus norvegicus 58-62 23231479-0 2014 Donepezil, an acetylcholinesterase inhibitor, attenuates nicotine self-administration and reinstatement of nicotine seeking in rats. Nicotine 57-65 acetylcholinesterase Rattus norvegicus 14-34