PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11478936-8	2001	Finally, a number of genes, involved in MAPK, phosphatidylinositol, and EGFR signaling pathways, were identified and proposed as possible targets in response to nicotine administration.	Nicotine	161-169	epidermal growth factor receptor	Rattus norvegicus	72-76	
1412511-1	1992	This study investigated the effect of two major ingredients in cigarette smoke, benzo[a]pyrene (BP) and nicotine, on epidermal growth factor (EGF) receptor binding and EGF-mediated cellular functions in rat buccal mucosa.	Nicotine	104-112	epidermal growth factor receptor	Rattus norvegicus	117-155	
12472891-0	2002	Nicotine-induced phosphorylation of Akt through epidermal growth factor receptor and Src in PC12h cells.	Nicotine	0-8	epidermal growth factor receptor	Rattus norvegicus	48-80	
12472891-7	2002	Three epidermal growth factor receptor (EGFR) inhibitors prevented the nicotine-induced phosphorylation of both extracellular signal-regulated protein kinase (p42/44 MAP kinase, ERK) and Akt.	Nicotine	71-79	epidermal growth factor receptor	Rattus norvegicus	6-38	
12472891-7	2002	Three epidermal growth factor receptor (EGFR) inhibitors prevented the nicotine-induced phosphorylation of both extracellular signal-regulated protein kinase (p42/44 MAP kinase, ERK) and Akt.	Nicotine	71-79	epidermal growth factor receptor	Rattus norvegicus	40-44	
12472891-9	2002	These results suggested that nicotine induces the activation of both PI3-kinase/Akt and ERK pathways via common pathways including non-alpha7-nAChRs, L-type VSCC, CaM kinase II and EGFR in PC12h cells, but Src family tyrosine kinases only participate in the pathway to activate Akt.	Nicotine	29-37	epidermal growth factor receptor	Rattus norvegicus	181-185	
17286987-0	2007	Nicotine-induced vascular endothelial growth factor release via the EGFR-ERK pathway in rat vascular smooth muscle cells.	Nicotine	0-8	epidermal growth factor receptor	Rattus norvegicus	68-72	
17286987-9	2007	Furthermore, AG1478, a selective inhibitor of epidermal growth factor receptor (EGFR) kinase, inhibited nicotine-induced ERK phosphorylation and VEGF release.	Nicotine	104-112	epidermal growth factor receptor	Rattus norvegicus	46-78	
17286987-9	2007	Furthermore, AG1478, a selective inhibitor of epidermal growth factor receptor (EGFR) kinase, inhibited nicotine-induced ERK phosphorylation and VEGF release.	Nicotine	104-112	epidermal growth factor receptor	Rattus norvegicus	80-84	
17286987-11	2007	Moreover, VEGF release induced by nicotine is mediated by an EGFR-ERK pathway in VSMC.	Nicotine	34-42	epidermal growth factor receptor	Rattus norvegicus	61-65	
15164609-8	2004	Nicotine induces the activation of both PI3 kinase/Act and ERK/CREB pathways via common pathways including non-alpha 7-nAChRs, L-type VSCC, CaM kinase and EGFR in PC12h cells, but Src family tyrosine kinases only participate in the pathway to activate Akt.	Nicotine	0-8	epidermal growth factor receptor	Rattus norvegicus	155-159