PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27840928-8	2016	The results indicated that treatment with nicotine significantly attenuated the clinical and histopathological changes associated with arthritis, reduced CD11b-positive macrophages in the synovium, and downregulated the serum expression levels of MIP-1alpha and MCP-1.	Nicotine	42-50	chemokine (C-C motif) ligand 2	Mus musculus	262-267	
31162139-7	2019	In vitro studies with cultures of LPS-stimulated peritoneal macrophages revealed a concentration-dependent reduction in CCL2 secretion following stimulation with ACh, nicotine and muscarine.	Nicotine	167-175	chemokine (C-C motif) ligand 2	Mus musculus	120-124	
22093924-3	2012	In muscles and C2C12 myotubes, cholinergic excitation by exposure to nicotine or the organophosphorous pesticide, Paraoxon, induced Tristetraprolin overproduction while reducing pro-inflammatory transcripts such as IL-6, CXCL1 (KC) and CCL2 (MCP-1).	Nicotine	69-77	chemokine (C-C motif) ligand 2	Mus musculus	236-240	
26810225-9	2016	Finally, mRNA transcript levels for CCL2 and CXCL2, chemokines involved in the chemotaxis of proinflammatory monocytes and neutrophils, respectively, are reduced in the brain of nicotine-treated EAE mice before the massive infiltration of these cells.	Nicotine	178-186	chemokine (C-C motif) ligand 2	Mus musculus	36-40	
27688602-6	2016	In vitro, nicotine induced the expression of MCP-1 and RANTES in both RAW264.7 (mouse macrophage) and MOVAS (mouse vascular smooth muscle) cells in a dose-dependent manner; expression was upregulated by 0.5 ng/mL nicotine but strongly downregulated by 500 ng/mL nicotine.	Nicotine	10-18	chemokine (C-C motif) ligand 2	Mus musculus	45-50	
27688602-6	2016	In vitro, nicotine induced the expression of MCP-1 and RANTES in both RAW264.7 (mouse macrophage) and MOVAS (mouse vascular smooth muscle) cells in a dose-dependent manner; expression was upregulated by 0.5 ng/mL nicotine but strongly downregulated by 500 ng/mL nicotine.	Nicotine	213-221	chemokine (C-C motif) ligand 2	Mus musculus	45-50	
27688602-6	2016	In vitro, nicotine induced the expression of MCP-1 and RANTES in both RAW264.7 (mouse macrophage) and MOVAS (mouse vascular smooth muscle) cells in a dose-dependent manner; expression was upregulated by 0.5 ng/mL nicotine but strongly downregulated by 500 ng/mL nicotine.	Nicotine	213-221	chemokine (C-C motif) ligand 2	Mus musculus	45-50	
27688602-8	2016	In conclusion, SP600125 attenuates nicotine plus AngII-induced AAA formation likely by inhibiting MMP-2, MMP-9, MCP-1, and RANTES.	Nicotine	35-43	chemokine (C-C motif) ligand 2	Mus musculus	112-117	
25616906-7	2015	Nicotine downregulated production of IL-6 and MCP-1 in RA-FLSs induced by TNFalpha in a concentration-dependent manner, and IL-10 levels were not significantly different after nicotine pretreatment.	Nicotine	0-8	chemokine (C-C motif) ligand 2	Mus musculus	46-51	
25616906-11	2015	In conclusion, nicotine has an anti-inflammatory effect on RA by downregulating production of IL-6 and MCP-1 in FLSs, and this is mediated through activation of the JAK2-STAT3 signal pathway.	Nicotine	15-23	chemokine (C-C motif) ligand 2	Mus musculus	103-108	
22093924-3	2012	In muscles and C2C12 myotubes, cholinergic excitation by exposure to nicotine or the organophosphorous pesticide, Paraoxon, induced Tristetraprolin overproduction while reducing pro-inflammatory transcripts such as IL-6, CXCL1 (KC) and CCL2 (MCP-1).	Nicotine	69-77	chemokine (C-C motif) ligand 2	Mus musculus	242-247	
21597011-8	2011	Oral nicotine administration reduced inflammation within the myocardium, decreased the production of interleukin-6 and tumor necrosis factor-alpha, and downregulated the expression of monocyte chemoattractant protein-1, macrophage inflammatory protein-1beta, RANTES, CCR1, CCR2, and CCR5.	Nicotine	5-13	chemokine (C-C motif) ligand 2	Mus musculus	184-218	
21239632-4	2011	An analysis of the phenotype of isolated brain microvessels after nicotine exposure indicated higher expression of inflammatory mediators, cytokines (IL-1beta, TNF-alpha, and IL-18), chemokines (CCL2 and CX(3)CL1), and adhesion molecules (ICAM-1, VCAM-1, and P-selectins), and this was accompanied by enhanced leukocyte infiltration into brain during ischemia/reperfusion (P < 0.01).	Nicotine	66-74	chemokine (C-C motif) ligand 2	Mus musculus	195-199	
20579680-0	2010	Induction of monocyte chemoattractant protein-1 by nicotine in pancreatic ductal adenocarcinoma cells: role of osteopontin.	Nicotine	51-59	chemokine (C-C motif) ligand 2	Mus musculus	13-47	
20579680-4	2010	In this study, we explored the potential proinflammatory role of nicotine in PDA through studying its effect on the expression of monocyte chemoattractant protein (MCP)-1 and evaluated the role of OPN in mediating these effects.	Nicotine	65-73	chemokine (C-C motif) ligand 2	Mus musculus	130-170	
20579680-8	2010	RESULTS: Nicotine treatment significantly increased MCP-1 expression in PDA cells.	Nicotine	9-17	chemokine (C-C motif) ligand 2	Mus musculus	52-57	
20579680-13	2010	CONCLUSION: Our data suggest that cigarette smoking and nicotine may contribute to PDA inflammation by inducing MCP-1 and provide a novel insight into a unique role for OPN in mediating these effects.	Nicotine	56-64	chemokine (C-C motif) ligand 2	Mus musculus	112-117