PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34997096-7	2022	Furthermore, nicotine suppressed CCL21-induced bone marrow-derived pDC migration due to Rac 1 inactivation, which was reversed by methyllycaconitine, a JAK2 inhibitor AG490 or caspase-3 inhibitor AZ-10417808.	Nicotine	13-21	caspase 3	Mus musculus	176-185	
11682702-6	2001	The data showed that nicotine significantly blocked the formation of the DEX-induced 17-kDa caspase-3 subunit expression.	Nicotine	21-29	caspase 3	Mus musculus	92-101	
23737837-3	2013	Embryos exposed to nicotine (1 mM) exhibited severe morphological anomalies and apoptotic cell death, as well as increased levels of TNF- alpha , IL-1 beta , and caspase 3 mRNAs, and lipid peroxidation.	Nicotine	19-27	caspase 3	Mus musculus	162-171	
15831280-5	2005	MAIN OUTCOME MEASURE(S): The effect of nicotine on the occurrence of apoptosis was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, 4,6-diamidino-2-phenylindole staining, terminal deoxynuclotidyl transferase-mediated dUTP nick end labeling assay, DNA fragmentation assay, reverse transcription-polymerase chain reaction, caspase-3 enzyme assay, and Western blot analysis.	Nicotine	39-47	caspase 3	Mus musculus	356-365	
15831280-9	2005	In addition, nicotine enhanced the expression of the activated form of caspase-3 and caspase-3 enzyme activity.	Nicotine	13-21	caspase 3	Mus musculus	71-80	
15831280-9	2005	In addition, nicotine enhanced the expression of the activated form of caspase-3 and caspase-3 enzyme activity.	Nicotine	13-21	caspase 3	Mus musculus	85-94	
15831280-10	2005	CONCLUSION(S): Nicotine appears to activate specific intracellular death-related pathways, probably by bax-dependent activation of caspase-3, inducing apoptosis in Leydig cells.	Nicotine	15-23	caspase 3	Mus musculus	131-140	
29906478-6	2018	Increased oxidative stress by tramadol and/or nicotine sequentially augmented nuclear factor kappa B and the proinflammatory cytokine tumor necrosis factor alpha with the induction of apoptosis evident by the increased caspase-3 immunoreactivity.	Nicotine	46-54	caspase 3	Mus musculus	219-228	
29062606-7	2017	Cleaved Poly (ADP-ribose) polymerase-1 (PARP-1) and cleaved caspase-3 were decreased by nicotine in 6-hydroxydopamine (6-OHDA) lesioned mice and in MPP+-treated SH-SY5Y cells.	Nicotine	88-96	caspase 3	Mus musculus	60-69	
28240526-4	2017	Result: In the heart and lung, nicotine caused significant decrease in P53, Bax and Caspase-3 mRNAexpression levels compared to the control group.	Nicotine	31-39	caspase 3	Mus musculus	84-93	
24399025-6	2014	Meanwhile, nicotine afforded protection against cisplatin-induced toxicity through inhibiting caspase-3 activation and upregulating anti-apoptotic protein expression.	Nicotine	11-19	caspase 3	Mus musculus	94-103	
24399025-7	2014	Further exploration demonstrated that nicotine efficiently abolished cisplatin-promoted mitochondria translocation of Bax and the release of cytochrome c. The pretreatment of alpha-bungarotoxin and tubocurarine chloride significantly attenuated nicotine-augmented cell viability, abolished caspase-3 activation and alpha7 nAChR upregulation.	Nicotine	38-46	caspase 3	Mus musculus	290-299	
17520028-8	2007	Reduced tubular damage in nicotine pre-treated mice was associated with a decrease in tubular cell apoptosis and proliferative response as attested by the reduction of caspase-3 and Ki67 positive cells, respectively.	Nicotine	26-34	caspase 3	Mus musculus	168-177	
11682702-8	2001	Addition of d-tubocurarine chloride (dTC), a general nicotinic receptor antagonist, inhibited nicotine downregulation of the DEX-induced active caspase-3 expression, providing evidence that this action of nicotine was receptor-mediated.	Nicotine	94-102	caspase 3	Mus musculus	144-153	
11682702-8	2001	Addition of d-tubocurarine chloride (dTC), a general nicotinic receptor antagonist, inhibited nicotine downregulation of the DEX-induced active caspase-3 expression, providing evidence that this action of nicotine was receptor-mediated.	Nicotine	205-213	caspase 3	Mus musculus	144-153