PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1891072-5	1991	Subacute nicotine decreased splenic concentrations of native and cryptic Met-enkephalin and native Leu-enkephalin, consistent with increased release of Met- and Leu-enkephalin from spleen and decreased synthesis of proenkephalin A or inadequate processing of larger peptides to enkephalin pentapeptides in spleen to compensate for the increased release during this period.	Nicotine	9-17	prodynorphin	Homo sapiens	99-113	
7949240-0	1994	Effects of nicotine on the concentration of native and cryptic Met- and Leu-enkephalin in peripheral tissues.	Nicotine	11-19	prodynorphin	Homo sapiens	72-86	
7949240-6	1994	This regimen of nicotine also affected the concentration of Leu-enkephalin in adrenal medulla, jejunum and spleen.	Nicotine	16-24	prodynorphin	Homo sapiens	60-74	
1891072-0	1991	Nicotine-induced alterations in peripheral tissue concentrations of native and cryptic Met- and Leu-enkephalin.	Nicotine	0-8	prodynorphin	Homo sapiens	96-110	
1891072-4	1991	Subacute repeated administration of nicotine 0.1 mg/kg ip, six times at 30 min intervals, increased native Met- and Leu-enkephalin in adrenal medulla without affecting cryptic Met- and Leu-enkephalin concentrations, consistent with increased processing of larger peptides to Met- and Leu-enkephalin.	Nicotine	36-44	prodynorphin	Homo sapiens	116-130	
1891072-5	1991	Subacute nicotine decreased splenic concentrations of native and cryptic Met-enkephalin and native Leu-enkephalin, consistent with increased release of Met- and Leu-enkephalin from spleen and decreased synthesis of proenkephalin A or inadequate processing of larger peptides to enkephalin pentapeptides in spleen to compensate for the increased release during this period.	Nicotine	9-17	prodynorphin	Homo sapiens	161-175	
1891072-7	1991	Nicotine also increased native Met-enkephalin in jejunum, decreased cryptic Met-enkephalin in heart atrium, increased native Leu-enkephalin in anterior pituitary and decreased cryptic Leu-enkephalin in jejunum.	Nicotine	0-8	prodynorphin	Homo sapiens	125-139	
1891072-7	1991	Nicotine also increased native Met-enkephalin in jejunum, decreased cryptic Met-enkephalin in heart atrium, increased native Leu-enkephalin in anterior pituitary and decreased cryptic Leu-enkephalin in jejunum.	Nicotine	0-8	prodynorphin	Homo sapiens	184-198	
2882641-7	1987	Nicotine (10(-5), 10(-4) mol/l) significantly stimulated the secretion of immunoreactive alpha-neoendorphin and dynorphin as well as leu-enkephalin and catecholamines from cultured human phaeochromocytoma cells.	Nicotine	0-8	prodynorphin	Homo sapiens	133-147