PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28082123-0 2017 Nicotine suppresses the neurotoxicity by MPP+/MPTP through activating alpha7nAChR/PI3K/Trx-1 and suppressing ER stress. Nicotine 0-8 thioredoxin 1 Mus musculus 87-92 28082123-5 2017 The expression of thioredoxin-1(Trx-1) was decreased by MPP+, which was restored by nicotine. Nicotine 84-92 thioredoxin 1 Mus musculus 32-37 28082123-8 2017 Consistently, pretreatment with nicotine ameliorated the motor ability, restored the declines of Trx-1 and tyrosine hydroxylase (TH), and suppressed the expressions of Bip and CHOP induced by 1-Methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice. Nicotine 32-40 thioredoxin 1 Mus musculus 97-102 28082123-9 2017 Our results suggest that nicotine plays role in resisting MPP+/MPTP neurotoxicity through activating the alpha7nAChR/PI3K/Trx-1 pathway and suppressing ER stress. Nicotine 25-33 thioredoxin 1 Mus musculus 122-127 31525533-8 2019 Our data showed that nicotine upregulated Trx, GTPBP4, DIRAS2, and downregulated ASK1 in 4NQO-induced OLK in mice, at least in part dependent on Prx1. Nicotine 21-29 thioredoxin 1 Mus musculus 42-45 31525533-9 2019 The modulations of Trx, GTPBP4, DIRAS2 and ASK1 by nicotine were also found in OLK smokers compared to OLK non-smokers. Nicotine 51-59 thioredoxin 1 Mus musculus 19-22