PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23869743-7	2015	Intra-CeA MPZP infusion prevented abstinence-induced increases in nicotine intake and nociceptive hypersensitivity.	Nicotine	66-74	carcinoembryonic antigen gene family 4	Rattus norvegicus	6-9	
29496477-7	2018	In drug-naive pups, acute nicotine stimulated IEGs expression specifically in brain areas associated with innate anxiety including the paraventricular hypothalamic nucleus, central nucleus of the amygdala (CeA), and locus coeruleus (LC).	Nicotine	26-34	carcinoembryonic antigen gene family 4	Rattus norvegicus	206-209	
29496477-8	2018	Following CNN, acute nicotine stimulated IEG expression in all three areas, but activation was significantly reduced in the LC (c-Fos, Egr-1, Npas4), and CeA (c-Fos).	Nicotine	21-29	carcinoembryonic antigen gene family 4	Rattus norvegicus	154-157	
19145226-7	2009	The administration of the nonspecific CRF1/2 receptor antagonist D-Phe CRF((12-41)) into the CeA and the Nacc shell prevented the mecamylamine-induced elevations in brain reward thresholds in the nicotine-dependent rats.	Nicotine	196-204	carcinoembryonic antigen gene family 4	Rattus norvegicus	93-96	
22182462-3	2012	It was investigated if blockade of CRF1 receptors, blockade of alpha1-adrenergic receptors, or stimulation of alpha2-adrenergic receptors in the CeA diminishes the deficit in brain reward function associated with nicotine withdrawal in rats.	Nicotine	213-221	carcinoembryonic antigen gene family 4	Rattus norvegicus	145-148	
20546793-6	2010	In Experiment 2, in situ hybridization was used to assess, in different male adolescent and adult rats, CRF mRNA expression in the BNST, PVN and CeA in response to acute nicotine.	Nicotine	170-178	carcinoembryonic antigen gene family 4	Rattus norvegicus	145-148	
19145226-9	2009	These studies indicate that the negative emotional state associated with precipitated nicotine withdrawal is at least partly mediated by an increased release of CRF in the CeA and the Nacc shell.	Nicotine	86-94	carcinoembryonic antigen gene family 4	Rattus norvegicus	172-175	
18418357-8	2009	Furthermore, nicotine (1 microM) increased NMDA receptor-mediated excitatory postsynaptic currents in rat CeA slices, similar to its previously described effects in the VTA.	Nicotine	13-21	carcinoembryonic antigen gene family 4	Rattus norvegicus	106-109	
18848603-9	2008	Acute nicotine resulted in significant induction of c-fos expression in the PVN and CeA at P5, P7 and P10, and in the BST at P7 and P10.	Nicotine	6-14	carcinoembryonic antigen gene family 4	Rattus norvegicus	84-87	
18848603-10	2008	Acute nicotine significantly induced expression of Arc in CeA at P5, P7 and P10, and in the BST at P10.	Nicotine	6-14	carcinoembryonic antigen gene family 4	Rattus norvegicus	58-61	
18849647-3	2008	Bilateral administration of nicotine (1 and 2 microg/rat; 1 microl/rat; 0.5 microl/rat in each side) into the central amygdala (intra-CeA) induced an anxiogenic-like effect, shown by specific decreases in the percentage of open-arm time (%OAT) and percentage of open arm entries (%OAE).	Nicotine	28-36	carcinoembryonic antigen gene family 4	Rattus norvegicus	134-137	
16739166-1	2006	Nicotine has been shown to activate stress-related brain nuclei, including the paraventricular nucleus of the hypothalamus (PVN) and the central nucleus of the amygdala (CEA), through complex mechanisms involving direct and indirect pathways.	Nicotine	0-8	carcinoembryonic antigen gene family 4	Rattus norvegicus	170-173	
16739166-5	2006	Film autoradiographic studies showed that nicotine significantly increased c-fos mRNA expression in both PVN and CEA.	Nicotine	42-50	carcinoembryonic antigen gene family 4	Rattus norvegicus	113-116	
16739166-8	2006	In contrast, there was no significant nicotine-induced increase in c-fos expression in CEA CRF or DYN cells, whereas nicotine treatment did increase c-fos expression within CEA ENK cells.	Nicotine	117-125	carcinoembryonic antigen gene family 4	Rattus norvegicus	173-176	
17287824-9	2007	Nicotine induced c-fos expression in the bed nucleus of the stria terminalis, the central nucleus of the amygdala (CeA), nucleus accumbens, and the superior colliculus (SC) at both ages, whereas it activated the hypothalamic paraventricular nucleus (PVN) and consequent corticosterone secretion only in adults.	Nicotine	0-8	carcinoembryonic antigen gene family 4	Rattus norvegicus	115-118	
17287824-10	2007	Acetaldehyde potentiated nicotine-induced c-fos in CeA and SC, and activation of PVN c-fos expression/plasma corticosterone release; however, this drug interaction was only observed in behaviorally tested animals, not those that were minimally stressed.	Nicotine	25-33	carcinoembryonic antigen gene family 4	Rattus norvegicus	51-54