PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18835254-0	2008	Nicotine induces cell proliferation in association with cyclin D1 up-regulation and inhibits cell differentiation in association with p53 regulation in a murine pre-osteoblastic cell line.	Nicotine	0-8	transformation related protein 53, pseudogene	Mus musculus	134-137	
18835254-4	2008	Nicotine induced cell proliferation in association with p53 down-regulation and cyclin D1 up-regulation.	Nicotine	0-8	transformation related protein 53, pseudogene	Mus musculus	56-59	
18835254-6	2008	Furthermore, p53 expression was sustained in nicotine-treated cells during differentiation.	Nicotine	45-53	transformation related protein 53, pseudogene	Mus musculus	13-16	
18835254-7	2008	These findings indicate that nicotine promotes the cell cycle and inhibits differentiation in association with p53 regulation in pre-osteoblastic cells.	Nicotine	29-37	transformation related protein 53, pseudogene	Mus musculus	111-114	
35463776-8	2022	In addition, irisin inhibits nicotine-mediated endothelial senescence and cell cycle arrest in G0/G1 phase via P53/P21 pathway.	Nicotine	29-37	transformation related protein 53, pseudogene	Mus musculus	111-114	
23275008-7	2013	Moreover, BCX supplementation restored the nicotine-suppressed expression of lung SIRT1, p53, and RAR-beta to that of the control group, increased survival probability, and decreased the levels of lung il-6 mRNA and phosphorylation of AKT.	Nicotine	43-51	transformation related protein 53, pseudogene	Mus musculus	89-92	
28240526-4	2017	Result: In the heart and lung, nicotine caused significant decrease in P53, Bax and Caspase-3 mRNAexpression levels compared to the control group.	Nicotine	31-39	transformation related protein 53, pseudogene	Mus musculus	71-74