PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33352289-9 2021 Chronic nicotine administration led to an increase of microglial cells in the dorsal horn of the spinal cord and increased expression levels of the cytokines TNFalpha and COX-2. Nicotine 8-16 tumor necrosis factor Rattus norvegicus 158-166 34309798-0 2021 Flavocoxid Ameliorates Aortic Calcification Induced by Hypervitaminosis D3 and Nicotine in Rats Via Targeting TNF-alpha, IL-1beta, iNOS, and Osteogenic Runx2. Nicotine 79-87 tumor necrosis factor Rattus norvegicus 110-119 31330570-5 2020 Extinction and cue-induced reinstatement of nicotine seeking was also associated with increased tumor necrosis factor alpha (TNFalpha) and decreased glial fibrillary acidic protein (GFAP) expression in the NAcore. Nicotine 44-52 tumor necrosis factor Rattus norvegicus 96-123 33091562-7 2020 Nicotine reversed the LPS-evoked modest rises in serum TNFalpha and IL-1beta while had no effect on associated arterial baroreflex dysfunction, inferring no roles for inflammation or baroreflexes in LPS-nicotine interaction. Nicotine 0-8 tumor necrosis factor Rattus norvegicus 55-63 32835699-7 2020 A significant upregulation in mRNA expression of TNF-alpha, IL-1beta, MCP-1, and caspase 3, caspase 8, caspase 9 was found in the PE-like rats compared to the control animals, the immunoreactivity of placental MCP-1, TNFR1, and apoptosis-related proteins (caspase 3, caspase 8, caspase 9, Bax) was also enhanced; nicotine treatment significantly reversed those changes. Nicotine 313-321 tumor necrosis factor Rattus norvegicus 49-58 31330570-5 2020 Extinction and cue-induced reinstatement of nicotine seeking was also associated with increased tumor necrosis factor alpha (TNFalpha) and decreased glial fibrillary acidic protein (GFAP) expression in the NAcore. Nicotine 44-52 tumor necrosis factor Rattus norvegicus 125-133 31330570-10 2020 Viral manipulation of the NF-kappaB pathway, which is downstream of TNFalpha, revealed that cue-induced nicotine seeking is regulated by NF-kappaB pathway signaling in the NAcore independent of GLT-1 expression. Nicotine 104-112 tumor necrosis factor Rattus norvegicus 68-76 27832994-0 2016 Possible involvement of iNOS and TNF-alpha in nutritional intervention against nicotine-induced pancreatic islet cell damage. Nicotine 79-87 tumor necrosis factor Rattus norvegicus 33-42 32198107-12 2020 In addition, nicotine treatment increased lipid peroxidation and the levels of oxidized form of glutathione (GSSG), interleukin 1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and Bax protein, while decreasing reduced form of glutathione (GSH), Bcl-2 protein, P-CREB and BDNF levels in the hippocampus of experimental animals. Nicotine 13-21 tumor necrosis factor Rattus norvegicus 147-174 32198107-12 2020 In addition, nicotine treatment increased lipid peroxidation and the levels of oxidized form of glutathione (GSSG), interleukin 1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and Bax protein, while decreasing reduced form of glutathione (GSH), Bcl-2 protein, P-CREB and BDNF levels in the hippocampus of experimental animals. Nicotine 13-21 tumor necrosis factor Rattus norvegicus 176-185 30009813-9 2018 Elevations in serum tumor necrosis factor-alpha (TNF-alpha) observed in LPS-treated rats were compromised upon co-administration of nicotine, PHA, or 5IA. Nicotine 132-140 tumor necrosis factor Rattus norvegicus 20-47 30009813-9 2018 Elevations in serum tumor necrosis factor-alpha (TNF-alpha) observed in LPS-treated rats were compromised upon co-administration of nicotine, PHA, or 5IA. Nicotine 132-140 tumor necrosis factor Rattus norvegicus 49-58 29065194-8 2018 Additionally, nicotine suppressed the surgery-induced release of IL-1beta, TNF-alpha, HMGB1, and NF-kappaB p65 in the hippocampus on postoperative day 1 and day 3. Nicotine 14-22 tumor necrosis factor Rattus norvegicus 75-84 28944930-8 2017 Treatment with nicotine decreased AP and osteocalcin levels, increased TNF-alpha and COX-2 expression levels, and led to alveolar bone loss compared with the control group. Nicotine 15-23 tumor necrosis factor Rattus norvegicus 71-80 28608236-12 2017 In addition, nicotine treatment increased lipid peroxidation and the levels of GSH, IL-1beta, TNF-alpha and Bax, while reducing Bcl-2, P-CREB and BDNF levels in the hippocampus. Nicotine 13-21 tumor necrosis factor Rattus norvegicus 94-103 28691127-8 2017 It is worthy to note that nicotine toxicity induced significant increments in serum inflammatory markers: tumor necrosis factor-alpha and vascular cell adhesion protein 1. Nicotine 26-34 tumor necrosis factor Rattus norvegicus 106-133 31403667-8 2020 By real-time PCR test, the mRNA of alpha 4 nAChR and beta 2 nAChR in rats given nicotine increased significantly compared with ischemic rats and decreased TNF-alpha, IL-1beta, and IL-6 mRNA (all ps < .05). Nicotine 80-88 tumor necrosis factor Rattus norvegicus 155-164 31486397-6 2019 Treatment with nicotine decreased local levels of TNF-alpha and IL-1beta, and increased the expression of GAP-43. Nicotine 15-23 tumor necrosis factor Rattus norvegicus 50-59 29236702-6 2017 In the peritoneal macrophages from obese rats, tumor necrosis factor (TNF) alpha, interleukin 1beta and CD36 were increased, and were further increased in nicotine-treated obese rats. Nicotine 155-163 tumor necrosis factor Rattus norvegicus 47-80 27832994-5 2016 Supplementation with folic acid and vitamin B12 suppressed the nicotine induced changes in HbA1c, insulin, TNF-alpha, IL-6, generation of reactive oxygen species, and attenuated the changes in markers of oxidative stress. Nicotine 63-71 tumor necrosis factor Rattus norvegicus 107-116 27832994-6 2016 Moreover, folic acid and vitamin B12 also counteracted the increased expression of protein and mRNA contents of TNF-alpha and iNOS produced by nicotine. Nicotine 143-151 tumor necrosis factor Rattus norvegicus 112-121 26097542-8 2015 Nicotine treatment ameliorated cartilage destruction, promoted matrix production, reduced the serum level of TNF-alpha and the expression of TNF-alpha in the synovial tissue, and increased the expression of alpha7nAChR in the synovial tissue in the rat model of early stage OA. Nicotine 0-8 tumor necrosis factor Rattus norvegicus 109-118 26875732-2 2016 Nicotine has been reported to inhibit TNF-alpha, IL-1, and ROS production in microglia. Nicotine 0-8 tumor necrosis factor Rattus norvegicus 38-47 26992678-7 2016 RESULTS: Nicotine suppresses LPS-stimulated placental proinflammatory cytokines (IL-1, IL-2, IL-6, TNF-alpha, IFN-gamma) production except IL-17 in vitro, and reduces leucocytes infiltration in the placental chorionic plate caused by LPS in vivo. Nicotine 9-17 tumor necrosis factor Rattus norvegicus 99-108 25973643-7 2016 Moreover, folic acid in combination with vitamin B12 also attenuated the nicotine-induced changes in markers of oxidative stress (17-88% recovery), TNF-alpha (40-99% recovery), and IL-6 level (47-65% recovery), CRP level (59-73% recovery), expression of NF-kappaB and caspase-3, and apoptosis in pancreatic islet cells. Nicotine 73-81 tumor necrosis factor Rattus norvegicus 148-157 26259694-3 2015 We found that acute nicotine injection markedly attenuated LPS-elicited cognitive deficits and suppressed the strong LPS-induced release of IL-1beta, IL-6, and TNF-alpha into serum and the dorsal hippocampus at 4 and 24h after LPS injection. Nicotine 20-28 tumor necrosis factor Rattus norvegicus 160-169 26097542-8 2015 Nicotine treatment ameliorated cartilage destruction, promoted matrix production, reduced the serum level of TNF-alpha and the expression of TNF-alpha in the synovial tissue, and increased the expression of alpha7nAChR in the synovial tissue in the rat model of early stage OA. Nicotine 0-8 tumor necrosis factor Rattus norvegicus 141-150 18973546-12 2009 RESULTS: Compared with saline/saline-treated control rats, saline/nicotine-treated rats developed significantly more periodontal bone loss, and LPS provoked a significantly smaller increase in circulating levels of the cytokines tumour necrosis factor alpha (TNF-alpha), transforming growth factor 1beta (TGF-1beta) and interleukin-10 (IL-10). Nicotine 66-74 tumor necrosis factor Rattus norvegicus 259-268 25671045-10 2014 Nicotine treatment led to a decrease of the effect of the burn trauma with significantly lower concentrations of tumor necrosis factor alpha, interleukin 1 beta, and interleukin 6 compared to the trauma group. Nicotine 0-8 tumor necrosis factor Rattus norvegicus 113-140 24769008-6 2014 Nicotine treatment significantly reduces LPS-induced TNF-alpha and IL-6 concentrations (P < .001) but does not change (P > .05) IL-10 levels. Nicotine 0-8 tumor necrosis factor Rattus norvegicus 53-62 24044905-9 2014 Furthermore, the intervention of enalapril in nicotine-treated diabetic rat attenuated the testicular damage and restored sperm count, sperm DNA damage, as well as reduced the expression of NF-kappaB, COX-2, and TNF-alpha. Nicotine 46-54 tumor necrosis factor Rattus norvegicus 212-221 25242867-6 2014 Mean +- SD serum level of IL-6 and TNF-alpha among all groups exposed to nicotine, except for 2 mg/kg nicotine injected group, was increased significantly (P < 0.0001). Nicotine 73-81 tumor necrosis factor Rattus norvegicus 35-44 20805763-10 2011 Cell experiments also showed that increases of TNF-alpha and IL-6 after LPS stimulation could be significantly inhibited by carbachol or nicotine, whereas IL-10 was not apparently altered. Nicotine 137-145 tumor necrosis factor Rattus norvegicus 47-56 18973546-13 2009 Mecamylamine pretreatment of nicotine-treated rats abrogated the increased periodontal bone loss and the LPS-induced TNF-alpha decrease, but had no significant effects on the levels of TGF-1beta and IL-10, or the stress hormone corticosterone. Nicotine 29-37 tumor necrosis factor Rattus norvegicus 117-126 15670336-9 2005 RESULTS: Rat microglial cells express alpha7 nicotinic receptor, and its activation by nicotine dose-dependently reduces the LPS-induced release of TNF-alpha, but has little or no effect on nitric oxide, interleukin-10 and interleukin-1beta. Nicotine 87-95 tumor necrosis factor Rattus norvegicus 148-157 17431097-6 2007 The reduction of proinflammatory cytokines (macrophage inflammatory protein-2 and TNF-alpha) in the BAL with nicotine probably resulted from the suppression of NF-kappaB activation in alveolar macrophages. Nicotine 109-117 tumor necrosis factor Rattus norvegicus 82-91 17581257-4 2007 Nicotine pretreatment considerably decreased microglial activation with significant reduction of tumour necrosis factor (TNF)-alpha mRNA expression and TNF-alpha release induced by LPS stimulation. Nicotine 0-8 tumor necrosis factor Rattus norvegicus 97-131 17581257-4 2007 Nicotine pretreatment considerably decreased microglial activation with significant reduction of tumour necrosis factor (TNF)-alpha mRNA expression and TNF-alpha release induced by LPS stimulation. Nicotine 0-8 tumor necrosis factor Rattus norvegicus 152-161 17581257-7 2007 Chronic nicotine pretreatment in rats showed that TH-ip neuronal loss induced by LPS stimulation in the substantia nigra was dramatically decreased, which was clearly accompanied by a reduction in the formation of TNF-alpha. Nicotine 8-16 tumor necrosis factor Rattus norvegicus 214-223 17525204-12 2007 However, nicotine decreased the endotoxin-induced elevation of interleukin (IL)-6, IL-1beta, tumor necrosis factor (TNF)-alpha, cytokine-induced neutrophil chemoattractant (CINC)-1, and monocyte chemotactic protein (MCP)-1, but did not affect IL-10 in the serum and aqueous humor. Nicotine 9-17 tumor necrosis factor Rattus norvegicus 93-126 21783733-11 2007 Renal function tests, LDH and TNF-alpha levels, which were increased significantly due to nicotine administration, were decreased with beta-glucan treatment. Nicotine 90-98 tumor necrosis factor Rattus norvegicus 30-39 16652343-7 2006 Moreover, nicotine modulation of LPS-induced TNF release was also blocked by xestospongin C. Upon LPS stimulation, inhibition of TNF release by nicotine was associated with the suppression of JNK and p38 MAP kinase activation, which regulate the post-transcriptional steps of TNF synthesis. Nicotine 144-152 tumor necrosis factor Rattus norvegicus 45-48 16652343-7 2006 Moreover, nicotine modulation of LPS-induced TNF release was also blocked by xestospongin C. Upon LPS stimulation, inhibition of TNF release by nicotine was associated with the suppression of JNK and p38 MAP kinase activation, which regulate the post-transcriptional steps of TNF synthesis. Nicotine 144-152 tumor necrosis factor Rattus norvegicus 129-132 16652343-7 2006 Moreover, nicotine modulation of LPS-induced TNF release was also blocked by xestospongin C. Upon LPS stimulation, inhibition of TNF release by nicotine was associated with the suppression of JNK and p38 MAP kinase activation, which regulate the post-transcriptional steps of TNF synthesis. Nicotine 144-152 tumor necrosis factor Rattus norvegicus 129-132 16652343-3 2006 Here we report that, in rat primary cultured microglia, nicotine enhances P2X(7) receptor-mediated TNF release, whilst suppressing LPS-induced TNF release but without affecting TNF mRNA expression via activation of alpha7 nicotinic acetylcholine receptors (alpha7 nAChRs). Nicotine 56-64 tumor necrosis factor Rattus norvegicus 99-102 16652343-3 2006 Here we report that, in rat primary cultured microglia, nicotine enhances P2X(7) receptor-mediated TNF release, whilst suppressing LPS-induced TNF release but without affecting TNF mRNA expression via activation of alpha7 nicotinic acetylcholine receptors (alpha7 nAChRs). Nicotine 56-64 tumor necrosis factor Rattus norvegicus 143-146 16652343-3 2006 Here we report that, in rat primary cultured microglia, nicotine enhances P2X(7) receptor-mediated TNF release, whilst suppressing LPS-induced TNF release but without affecting TNF mRNA expression via activation of alpha7 nicotinic acetylcholine receptors (alpha7 nAChRs). Nicotine 56-64 tumor necrosis factor Rattus norvegicus 143-146 16652343-7 2006 Moreover, nicotine modulation of LPS-induced TNF release was also blocked by xestospongin C. Upon LPS stimulation, inhibition of TNF release by nicotine was associated with the suppression of JNK and p38 MAP kinase activation, which regulate the post-transcriptional steps of TNF synthesis. Nicotine 10-18 tumor necrosis factor Rattus norvegicus 45-48 16652343-7 2006 Moreover, nicotine modulation of LPS-induced TNF release was also blocked by xestospongin C. Upon LPS stimulation, inhibition of TNF release by nicotine was associated with the suppression of JNK and p38 MAP kinase activation, which regulate the post-transcriptional steps of TNF synthesis. Nicotine 10-18 tumor necrosis factor Rattus norvegicus 129-132 16652343-7 2006 Moreover, nicotine modulation of LPS-induced TNF release was also blocked by xestospongin C. Upon LPS stimulation, inhibition of TNF release by nicotine was associated with the suppression of JNK and p38 MAP kinase activation, which regulate the post-transcriptional steps of TNF synthesis. Nicotine 10-18 tumor necrosis factor Rattus norvegicus 129-132 14745115-14 2004 These findings indicate that a single systematic administration of nicotine may attenuate the plasma exudation in the PSAR by suppressing the production of NO in the PMNs primed with TNF-alpha via nicotine-induced endogenous glucocorticoid. Nicotine 67-75 tumor necrosis factor Rattus norvegicus 183-192 14745115-14 2004 These findings indicate that a single systematic administration of nicotine may attenuate the plasma exudation in the PSAR by suppressing the production of NO in the PMNs primed with TNF-alpha via nicotine-induced endogenous glucocorticoid. Nicotine 197-205 tumor necrosis factor Rattus norvegicus 183-192 11172479-16 2001 These results suggest that oral nicotine administration reduces insulin resistance in obese diabetic rats by decreasing production of TNF-alpha in the visceral fat tissues. Nicotine 32-40 tumor necrosis factor Rattus norvegicus 134-143 14993259-7 2004 Nicotine may temporarily lower insulin sensitivity by stimulating the secretion of TNF-alpha and FFA, whereas long-term direct stimulation of nAChRs by nicotine in addition to autonomic nervous system stimulation may contribute to better insulin sensitivity in vivo through a modulated secretion of adipocytokines. Nicotine 0-8 tumor necrosis factor Rattus norvegicus 83-92