PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34159514-0 2021 The Intergenerational Transmission of Developmental Nicotine Exposure-Induced Neurodevelopmental Disorder-Like Phenotypes is Modulated by the Chrna5 D397N Polymorphism in Adolescent Mice. Nicotine 52-60 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 142-148 34803779-0 2021 Genetic Modifiers of Oral Nicotine Consumption in Chrna5 Null Mutant Mice. Nicotine 26-34 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 50-56 34803779-4 2021 Toward a better understanding of how loss of function of Chrna5 increases nicotine consumption, we have initiated efforts to identify genetic modifiers of Chrna5 deletion-dependent oral nicotine consumption in mice. Nicotine 74-82 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 57-63 34803779-4 2021 Toward a better understanding of how loss of function of Chrna5 increases nicotine consumption, we have initiated efforts to identify genetic modifiers of Chrna5 deletion-dependent oral nicotine consumption in mice. Nicotine 186-194 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 155-161 34803779-6 2021 As expected, nicotine consumption was significantly increased in Chrna5 KO mice relative to Chrna5 wildtype mice on a B6 background. Nicotine 13-21 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 65-71 34803779-7 2021 Among the CSS homozygous for the Chrna5 KO allele, several exhibited altered nicotine consumption relative to B6 Chrna5 KO mice. Nicotine 77-85 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 33-39 34803779-9 2021 In all cases nicotine consumption was reduced in the CSS Chrna5 KO mice relative to B6 Chrna5 KO mice and consumption in the CSS KO mice was indistinguishable from their wild type littermates. Nicotine 13-21 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 57-63 34803779-10 2021 Nicotine consumption was also reduced in both Chrna5 KO and wildtype CSS mice possessing A/J chromosome 1 and increased in both KO and wild type chromosome 17 CSS relative to KO and wild type B6 mice. Nicotine 0-8 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 46-52 34803779-11 2021 These results demonstrate the presence of several genetic modifiers of nicotine consumption in Chrna5 KO mice as well as identify loci that may affect nicotine consumption independent of Chrna5 genotype. Nicotine 71-79 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 95-101 34803779-12 2021 Identification of the genes that underlie the altered nicotine consumption may provide novel insight into the mechanism through which Chrna5 deletion increases nicotine consumption and, more generally, a better appreciation of the neurobiology of nicotine intake. Nicotine 54-62 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 134-140 34803779-12 2021 Identification of the genes that underlie the altered nicotine consumption may provide novel insight into the mechanism through which Chrna5 deletion increases nicotine consumption and, more generally, a better appreciation of the neurobiology of nicotine intake. Nicotine 160-168 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 134-140 34088738-3 2021 Much of the work on this system has focused on nicotinic mechanisms and their clinical implications for nicotine use, particularly because the IP expresses the alpha5 nicotinic receptor subunit, encoded by the CHRNA5 gene, which is genetically linked to smoking risk. Nicotine 104-112 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 210-216 25384568-3 2014 Here, we propose that the genetic locus of susceptibility to nicotine addiction, the CHRNA5/A3/B4 gene cluster, encoding the alpha5, alpha3 and beta4 subunits of the nicotinic acetylcholine receptors (nAChRs), may influence nicotine-induced neuroadaptations. Nicotine 61-69 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 85-91 29954848-0 2018 Chrna5-Expressing Neurons in the Interpeduncular Nucleus Mediate Aversion Primed by Prior Stimulation or Nicotine Exposure. Nicotine 105-113 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 0-6 29954848-3 2018 The Chrna5/a3/b4 locus is conserved in rodents and the restricted expression of these subunits suggests neural pathways through which the reinforcing and aversive properties of nicotine may be mediated. Nicotine 177-185 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 4-10 29954848-11 2018 These results using mice of both sexes support the idea that the risk allele of CHRNA5 may increase the drive to smoke via loss of IP-mediated nicotine aversion.SIGNIFICANCE STATEMENT Understanding the receptors and neural pathways underlying the reinforcing and aversive effects of nicotine may suggest new treatments for tobacco addiction. Nicotine 143-151 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 80-86 29954848-11 2018 These results using mice of both sexes support the idea that the risk allele of CHRNA5 may increase the drive to smoke via loss of IP-mediated nicotine aversion.SIGNIFICANCE STATEMENT Understanding the receptors and neural pathways underlying the reinforcing and aversive effects of nicotine may suggest new treatments for tobacco addiction. Nicotine 283-291 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 80-86 25498233-9 2015 As an example of the ability of a natural genetic variant to modify the effect of an engineered mutation, data will be presented that demonstrate that the effect of Chrna5 deletion on oral nicotine intake is dependent upon naturally occurring variant alleles of Chrna4. Nicotine 189-197 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 165-171 25384568-3 2014 Here, we propose that the genetic locus of susceptibility to nicotine addiction, the CHRNA5/A3/B4 gene cluster, encoding the alpha5, alpha3 and beta4 subunits of the nicotinic acetylcholine receptors (nAChRs), may influence nicotine-induced neuroadaptations. Nicotine 224-232 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 85-91 25384568-9 2014 Our results suggest that chronic nicotine treatment may represent a compensatory strategy in individuals with altered expression of the CHRNA5/A3/B4 region. Nicotine 33-41 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 136-142 24055499-0 2014 Chrna5 genotype determines the long-lasting effects of developmental in vivo nicotine exposure on prefrontal attention circuitry. Nicotine 77-85 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 0-6 24055499-10 2014 These findings suggest that chrna5 genotype can determine the effect of developmental in vivo nicotine on the prefrontal cortex. Nicotine 94-102 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 28-34 22101982-0 2012 Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects. Nicotine 88-96 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 22-28 22101982-8 2012 Our study provides the first in vivo evidence of the involvement of the CHRNA5/A3/B4 genomic cluster in nicotine addiction through modifying the activity of brain regions responsible for the balance between the rewarding and the aversive properties of this drug. Nicotine 104-112 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 72-78 24478678-1 2014 The CHRNA5-CHRNA3-CHRNB4 gene cluster, encoding the alpha5, alpha3, and beta4 nicotinic acetylcholine receptor (nAChR) subunits, has been linked to nicotine dependence. Nicotine 148-156 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 4-10 21555077-1 2011 Nicotine dependence is linked to single nucleotide polymorphisms in the CHRNB4-CHRNA3-CHRNA5 gene cluster encoding the alpha3beta4alpha5 nicotinic acetylcholine receptor (nAChR). Nicotine 0-8 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 86-92 21278726-2 2011 Here we report markedly increased nicotine intake in mice with a null mutation in Chrna5. Nicotine 34-42 cholinergic receptor, nicotinic, alpha polypeptide 5 Mus musculus 82-88