PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19969014-2	2010	This study was developed to examine how nicotine dependence alters endogenous opioid regulation of prolactin response, a peripheral marker of dopaminergic activity.	Nicotine	40-48	prolactin	Homo sapiens	99-108	
15939519-0	2005	Changes of smoking behavior and serum adrenocorticotropic hormone, cortisol, prolactin, and endogenous opioids levels in nicotine dependence after naltrexone treatment.	Nicotine	121-129	prolactin	Homo sapiens	77-86	
16318956-5	2005	Our results showed that 86.96% of the opium-dependent and 41.67 % of the nicotine-dependent group displayed high prolactin values (p<0.002).	Nicotine	73-81	prolactin	Homo sapiens	113-122	
12893845-13	2003	After high nicotine cigarette smoking, prolactin increased to hyperpro-lactinemic levels within 6 min and remained significantly above baseline levels for 42 min (P < 0.05-0.03).	Nicotine	11-19	prolactin	Homo sapiens	39-48	
1966302-2	1990	Measurement of plasma ACTH, cortisol, and prolactin showed that nicotine produced in both groups a dose-dependent increase in cortisol, with ACTH in both groups and prolactin in the Alzheimer"s group significantly elevated only by the 0.5 micrograms dose.	Nicotine	64-72	prolactin	Homo sapiens	42-51	
1966302-2	1990	Measurement of plasma ACTH, cortisol, and prolactin showed that nicotine produced in both groups a dose-dependent increase in cortisol, with ACTH in both groups and prolactin in the Alzheimer"s group significantly elevated only by the 0.5 micrograms dose.	Nicotine	64-72	prolactin	Homo sapiens	165-174	
6730939-3	1984	The lower PRL levels in cigarette-smoking pregnant women may be due either to a direct effect of nicotine or secondary to lower estrogen levels, and the finding may be of clinical importance in relation to lactation.	Nicotine	97-105	prolactin	Homo sapiens	10-13	
833259-3	1977	The effects of water loading, hypertonic saline infusion and nicotine on serum PRL and on renal water metabolism were investigated in 6 normal subjects and in 8 patients with chronic hyperprolactinemia (four with and four without demonstrable pituitary tumors).	Nicotine	61-69	prolactin	Homo sapiens	79-82