PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24401102-0	2014	Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans.	Nicotine	70-78	cholinergic receptor nicotinic beta 3 subunit	Homo sapiens	18-24	
28850771-10	2017	In a real data application, we apply our method to the sequencing data from Minnesota Twin Study (MTS) and found potential associations of several nicotine receptor subunit (CHRN) genes, including CHRNB3, associated with nicotine dependence and/or alcohol dependence.	Nicotine	147-155	cholinergic receptor nicotinic beta 3 subunit	Homo sapiens	197-203	
28851948-0	2017	Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population.	Nicotine	63-71	cholinergic receptor nicotinic beta 3 subunit	Homo sapiens	31-37	
24731518-2	2014	The beta3 nicotinic-acetylcholine receptor subunit (encoded by CHRNB3) is depleted in the striatum of PD patients and associated with nicotine dependence.	Nicotine	134-142	cholinergic receptor nicotinic beta 3 subunit	Homo sapiens	63-69	
24804708-4	2014	We previously undertook pooled sequencing of the coding regions and flanking sequence of the CHRNA5, CHRNA3, CHRNB4, CHRNA6 and CHRNB3 genes and found that rare missense variants at conserved residues in CHRNB4 are associated with reduced risk of nicotine dependence among African Americans.	Nicotine	247-255	cholinergic receptor nicotinic beta 3 subunit	Homo sapiens	128-134	
26318101-2	2015	SNPs in the putative promoter region of CHRNB3, the gene that encodes the beta3 subunit of the nicotinic acetylcholine receptor (nAChR), have been repeatedly associated with nicotine behaviors.	Nicotine	174-182	cholinergic receptor nicotinic beta 3 subunit	Homo sapiens	40-46	
24675634-7	2014	These results suggest that the CHRNB3-A6 locus contains multiple variants affecting risk for vulnerability to cocaine and nicotine dependence as well as bipolar disorder, suggesting that they have pleiotropic effects.	Nicotine	122-130	cholinergic receptor nicotinic beta 3 subunit	Homo sapiens	31-37	
22524403-0	2012	CHRNB3 is more strongly associated with Fagerstrom test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results.	Nicotine	87-95	cholinergic receptor nicotinic beta 3 subunit	Homo sapiens	0-6	
23319001-0	2013	Significant association of CHRNB3 variants with nicotine dependence in multiple ethnic populations.	Nicotine	48-56	cholinergic receptor nicotinic beta 3 subunit	Homo sapiens	27-33	
22524403-9	2012	FINDINGS: The genetic locus most strongly associated with nicotine dependence was rs1451240 on chromosome 8 in the region of CHRNB3 [odds ratio (OR) = 0.65, P = 2.4 x 10(-8) ].	Nicotine	58-66	cholinergic receptor nicotinic beta 3 subunit	Homo sapiens	125-131	
22042774-3	2012	We undertook pooled sequencing of the coding regions and flanking sequence of the CHRNA5, CHRNA3, CHRNB4, CHRNA6 and CHRNB3 genes in African American and European American nicotine-dependent smokers and smokers without symptoms of dependence.	Nicotine	172-180	cholinergic receptor nicotinic beta 3 subunit	Homo sapiens	117-123	
34368810-1	2021	Objective: The aim of this study was to examine if cholinergic receptor nicotinic beta 3 subunit (CHRNB3) was a common genetic basis for both nicotine dependence and schizophrenia.	Nicotine	142-150	cholinergic receptor nicotinic beta 3 subunit	Homo sapiens	51-96	
19500157-1	2009	The CHRNA6 and CHRNB3 genes have been associated with nicotine dependence and early subjective response to nicotine.	Nicotine	54-62	cholinergic receptor nicotinic beta 3 subunit	Homo sapiens	15-21	
19500157-1	2009	The CHRNA6 and CHRNB3 genes have been associated with nicotine dependence and early subjective response to nicotine.	Nicotine	107-115	cholinergic receptor nicotinic beta 3 subunit	Homo sapiens	15-21	
34368810-1	2021	Objective: The aim of this study was to examine if cholinergic receptor nicotinic beta 3 subunit (CHRNB3) was a common genetic basis for both nicotine dependence and schizophrenia.	Nicotine	142-150	cholinergic receptor nicotinic beta 3 subunit	Homo sapiens	98-104	
31164900-6	2019	However, results from our analysis suggest heterogeneous effects of CHRNA6 and CHRNB3 on nicotine dependence in males and females.	Nicotine	89-97	cholinergic receptor nicotinic beta 3 subunit	Homo sapiens	79-85