PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17613539-1 2007 Mutational analyses in xenopus oocyte and mice models indicate that the positive effect of nicotine on attention may be modulated by genetic variations within exon 5 of the alpha4 subunit of the nicotinergic acetylcholine receptor gene CHRNA4. Nicotine 91-99 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 236-242 16077034-4 2005 Given the known effects of nAChRs on dopaminergic neurotransmission, we assessed the ability of the alpha4 nAChR subunit to regulate arbor size of dopaminergic neurons by comparing responses of wild-type and alpha4 nAChR subunit knockout [alpha4(-/-)] mice to long-term exposure to cocaine, amphetamine, nicotine, and haloperidol, and after substantia nigra neurotoxic lesioning. Nicotine 304-312 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 100-112 14691373-4 2003 Pharmacogenetics 12:197-208) reported that a polymorphism (A529T) in the alpha4 nAChR subunit gene is associated with variability in nicotine"s effects on startle in the LSxSS recombinant inbred (RI) strains. Nicotine 133-141 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 73-85 15727510-0 2005 Modulation of nicotine but not ethanol preference by the mouse Chrna4 A529T polymorphism. Nicotine 14-22 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 63-69 15727510-3 2005 Data obtained with inbred mouse strains suggested an association between a polymorphism in the mouse alpha4 nAChR subunit gene, Chrna4, and variability in nicotine and ethanol preference. Nicotine 155-163 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 101-113 15727510-5 2005 The results obtained by the authors indicate that the polymorphism in Chrna4 plays an important role in modulating variability in oral nicotine intake but is linked to a gene that regulates alcohol intake. Nicotine 135-143 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 70-76 15617774-8 2005 A polymorphism in the nicotinic receptor alpha4 subunit gene, Chrna4, showed a trend with nicotine consumption and a significant association with alcohol consumption in female but not male mice. Nicotine 90-98 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 62-68 26355604-11 2015 In particular, co-administration of menthol and nicotine appears to promote significant increase in beta2 and alpha4 nAChR subunit expression in the hippocampus, prefrontal cortex and striatum of mice. Nicotine 48-56 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 110-122 10235262-6 1999 The alpha4 nAChR subunit, possibly associated with the beta2 nAChR subunit, is therefore crucial for nicotine-elicited antinociception. Nicotine 101-109 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 4-16 28585241-12 2018 CONCLUSIONS AND IMPLICATIONS: These results indicate that mice with reduced expression of the alpha4 nAChR subunit have a more robust response to chronic nicotine than mice with normal expression of this subunit. Nicotine 154-162 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 94-106 12871652-3 2003 Chrna4 A529T is associated with several measures of acute sensitivity to nicotine as well as with mouse strain differences in nicotine-stimulated (86)Rb(+) efflux from synaptosomes. Nicotine 73-81 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 0-6 12871652-3 2003 Chrna4 A529T is associated with several measures of acute sensitivity to nicotine as well as with mouse strain differences in nicotine-stimulated (86)Rb(+) efflux from synaptosomes. Nicotine 126-134 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 0-6 11434511-1 2001 In a recent study, we reported that a restriction fragment length polymorphism associated with the alpha4 nicotinic receptor gene (Chrna4) may play a role in regulating differential sensitivity of LS and SS mouse lines to the seizure-inducing effects of nicotine. Nicotine 254-262 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 131-137 11434511-8 2001 Thus, it may be that the Chrna4 T529A substitution leads to a difference in the ratio of the two receptor forms which then promotes differences in receptor function, as well as differential behavioural sensitivity to nicotine. Nicotine 217-225 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 25-31 28759616-0 2017 Altered nicotine reward-associated behavior following alpha4 nAChR subunit deletion in ventral midbrain. Nicotine 8-16 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 54-66 24750355-3 2015 alpha4-S248F mice contain a point mutation within the alpha4 nAChR subunit which confers increased sensitivity to nicotine and resistance to mecamylamine. Nicotine 114-122 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 54-66 25498233-9 2015 As an example of the ability of a natural genetic variant to modify the effect of an engineered mutation, data will be presented that demonstrate that the effect of Chrna5 deletion on oral nicotine intake is dependent upon naturally occurring variant alleles of Chrna4. Nicotine 189-197 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 262-268 20061993-0 2010 Chrna4 A529 knock-in mice exhibit altered nicotine sensitivity. Nicotine 42-50 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 0-6 20061993-4 2010 However, one genetic variant has been implicated in altering nicotine sensitivity in mice is a T529A polymorphism in Chrna4, the gene that encodes the nicotinic receptor (nAChR) alpha4 subunit. Nicotine 61-69 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 117-123 20061993-7 2010 Compared with Chrna4 T529 littermate controls, the Chrna4 A529 knock-in mice exhibited greater sensitivity to the hypothermic effects of nicotine, reduced oral nicotine consumption and did not develop conditioned place preference to nicotine. Nicotine 137-145 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 51-57 20061993-7 2010 Compared with Chrna4 T529 littermate controls, the Chrna4 A529 knock-in mice exhibited greater sensitivity to the hypothermic effects of nicotine, reduced oral nicotine consumption and did not develop conditioned place preference to nicotine. Nicotine 160-168 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 51-57 20061993-7 2010 Compared with Chrna4 T529 littermate controls, the Chrna4 A529 knock-in mice exhibited greater sensitivity to the hypothermic effects of nicotine, reduced oral nicotine consumption and did not develop conditioned place preference to nicotine. Nicotine 160-168 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 51-57 24107512-4 2014 Using cell-based sorting and proteomic analysis we define an alpha4 nAChR expressing helper T-cell population (alpha4(+)CD3(+)CD4(+)) and show that this group of cells is responsive to sustained nicotine exposure. Nicotine 195-203 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 61-73 24107512-5 2014 In the circulation, spleen, bone marrow, and thymus, we find that nicotine promotes an increase in CD3(+)CD4(+) cells via its activation of the alpha4 nAChR and regulation of G protein subunit o, G protein regulated-inducer of neurite outgrowth, and CDC42 signaling within T cells. Nicotine 66-74 cholinergic receptor, nicotinic, alpha polypeptide 4 Mus musculus 144-156