PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10525113-4	1999	Multiple injections of nicotine bitartrate (5 mg/kg) elevated mRNA levels for the catecholamine biosynthetic enzymes, tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase, and of preproneuropeptide Y in rat adrenal medulla more than did 1 mg/kg of nicotine bitartrate.	Nicotine	23-42	phenylethanolamine-N-methyltransferase	Rattus norvegicus	182-220	
12438084-10	2002	By contrast, while muscarine, nicotine, or carbachol (100 micro M) also evoke rapid increases in rat PNMT promoter activity, peak activity is observed at 6 hours, followed by a decline and restoration to basal levels by 24 hours.	Nicotine	30-38	phenylethanolamine-N-methyltransferase	Rattus norvegicus	101-105	
9061614-7	1997	Nicotine treatment upregulated the expression of TH, PNMT, and NPY genes in a dose-dependent fashion.	Nicotine	0-8	phenylethanolamine-N-methyltransferase	Rattus norvegicus	53-57	
29246838-0	2018	Imidacloprid, a neonicotinoid insecticide, facilitates tyrosine hydroxylase transcription and phenylethanolamine N-methyltransferase mRNA expression to enhance catecholamine synthesis and its nicotine-evoked elevation in PC12D cells.	Nicotine	192-200	phenylethanolamine-N-methyltransferase	Rattus norvegicus	94-132	
29246838-12	2018	When the chromaffin cells were treated with nicotine in the presence of the insecticide, nicotine-elevated adrenaline production was enhanced due to facilitation of nicotine-increased TH and PNMT protein expression, and simultaneous enhancement of nicotine-elevated adrenaline secretion also took place.	Nicotine	44-52	phenylethanolamine-N-methyltransferase	Rattus norvegicus	191-195	
29246838-12	2018	When the chromaffin cells were treated with nicotine in the presence of the insecticide, nicotine-elevated adrenaline production was enhanced due to facilitation of nicotine-increased TH and PNMT protein expression, and simultaneous enhancement of nicotine-elevated adrenaline secretion also took place.	Nicotine	89-97	phenylethanolamine-N-methyltransferase	Rattus norvegicus	191-195	
29246838-12	2018	When the chromaffin cells were treated with nicotine in the presence of the insecticide, nicotine-elevated adrenaline production was enhanced due to facilitation of nicotine-increased TH and PNMT protein expression, and simultaneous enhancement of nicotine-elevated adrenaline secretion also took place.	Nicotine	89-97	phenylethanolamine-N-methyltransferase	Rattus norvegicus	191-195	
29246838-12	2018	When the chromaffin cells were treated with nicotine in the presence of the insecticide, nicotine-elevated adrenaline production was enhanced due to facilitation of nicotine-increased TH and PNMT protein expression, and simultaneous enhancement of nicotine-elevated adrenaline secretion also took place.	Nicotine	89-97	phenylethanolamine-N-methyltransferase	Rattus norvegicus	191-195