PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2412241-0 1985 Biphasic effects of chronic nicotine treatment on hypothalamic immunoreactive beta-endorphin in the mouse. Nicotine 28-36 pro-opiomelanocortin-alpha Mus musculus 78-92 2412241-2 1985 Hypothalamic beta-E returned towards normal levels within 7 days and was observed to rise 50% above normal 14 days after the cessation of nicotine treatment. Nicotine 138-146 pro-opiomelanocortin-alpha Mus musculus 13-19 2984705-2 1985 Nicotine (6.1 microM) stimulated secretion of beta-endorphin immunoreactivity from C3H IPMB approximately twofold. Nicotine 0-8 pro-opiomelanocortin-alpha Mus musculus 46-60 2984705-3 1985 Secretion of alpha MSH immunoreactivity was stimulated approximately two- and sixfold by 6.1 microM and 12.2 microM nicotine, respectively. Nicotine 116-124 pro-opiomelanocortin-alpha Mus musculus 13-22 2984705-5 1985 The data suggest nicotine acts in the brain to stimulate pituitary secretion of alpha MSH and beta-endorphin. Nicotine 17-25 pro-opiomelanocortin-alpha Mus musculus 80-89 2984705-5 1985 The data suggest nicotine acts in the brain to stimulate pituitary secretion of alpha MSH and beta-endorphin. Nicotine 17-25 pro-opiomelanocortin-alpha Mus musculus 94-108 20941594-1 2011 RATIONALE: The synthesis and release of met-enkephalin and beta-endorphin, endogenous ligands for delta-opioid peptide receptors (DOPrs), are altered following nicotine administration and may play a role in nicotine addiction. Nicotine 160-168 pro-opiomelanocortin-alpha Mus musculus 40-54 21659607-0 2011 Nicotine decreases food intake through activation of POMC neurons. Nicotine 0-8 pro-opiomelanocortin-alpha Mus musculus 53-57 20941594-1 2011 RATIONALE: The synthesis and release of met-enkephalin and beta-endorphin, endogenous ligands for delta-opioid peptide receptors (DOPrs), are altered following nicotine administration and may play a role in nicotine addiction. Nicotine 207-215 pro-opiomelanocortin-alpha Mus musculus 40-54 20941594-1 2011 RATIONALE: The synthesis and release of met-enkephalin and beta-endorphin, endogenous ligands for delta-opioid peptide receptors (DOPrs), are altered following nicotine administration and may play a role in nicotine addiction. Nicotine 207-215 pro-opiomelanocortin-alpha Mus musculus 59-73 29791746-1 2018 Nicotine, acting through nicotinic acetylcholine receptors (nAChRs), increases the firing rate of both orexigenic agouti-related peptide (AgRP) and anorexigenic pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC), yet nicotine and other nAChR agonists decrease food intake in mice. Nicotine 0-8 pro-opiomelanocortin-alpha Mus musculus 161-181 29791746-1 2018 Nicotine, acting through nicotinic acetylcholine receptors (nAChRs), increases the firing rate of both orexigenic agouti-related peptide (AgRP) and anorexigenic pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC), yet nicotine and other nAChR agonists decrease food intake in mice. Nicotine 0-8 pro-opiomelanocortin-alpha Mus musculus 183-187 29791746-1 2018 Nicotine, acting through nicotinic acetylcholine receptors (nAChRs), increases the firing rate of both orexigenic agouti-related peptide (AgRP) and anorexigenic pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC), yet nicotine and other nAChR agonists decrease food intake in mice. Nicotine 251-259 pro-opiomelanocortin-alpha Mus musculus 183-187 24035914-7 2014 In addition, this receptor is essential to mediate rewarding properties of non-opioid drugs of abuse, with a demonstrated implication of beta-endorphin for cocaine and nicotine. Nicotine 168-176 pro-opiomelanocortin-alpha Mus musculus 137-151 20941594-1 2011 RATIONALE: The synthesis and release of met-enkephalin and beta-endorphin, endogenous ligands for delta-opioid peptide receptors (DOPrs), are altered following nicotine administration and may play a role in nicotine addiction. Nicotine 160-168 pro-opiomelanocortin-alpha Mus musculus 59-73 18602444-5 2008 The existing information indicating the importance of beta-endorphin neurotransmission in mediating the reward pathways of nicotine and THC, is thus far circumstantial. Nicotine 123-131 pro-opiomelanocortin-alpha Mus musculus 54-68 20803089-5 2010 While, nicotine treatment for 14 days induced an increase in hypothalamic agouti-related protein, cocaine- and amphetamine- regulated transcript, pro-opiomelanocortin mRNA expressions, nicotine also produced a reducing effect in body weight gain and leptin concentration in NF mice. Nicotine 7-15 pro-opiomelanocortin-alpha Mus musculus 146-166 19376143-0 2009 Nicotine anxiogenic and rewarding effects are decreased in mice lacking beta-endorphin. Nicotine 0-8 pro-opiomelanocortin-alpha Mus musculus 72-86 19376143-7 2009 Mice lacking beta-endorphin exhibited a spontaneous hypoalgesia and hyperlocomotion and a reduction on the anxiogenic and rewarding effects induced by nicotine. Nicotine 151-159 pro-opiomelanocortin-alpha Mus musculus 13-27 19376143-9 2009 The dissociation between nicotine rewarding properties and physical dependence suggests a differential implication of beta-endorphin in these addictive related responses. Nicotine 25-33 pro-opiomelanocortin-alpha Mus musculus 118-132 18048009-0 2008 Involvement of spinal Met-enkephalin in nicotine-induced antinociception in mice. Nicotine 40-48 pro-opiomelanocortin-alpha Mus musculus 22-36 12023068-0 2002 Met-enkephalin and preproenkephalin mRNA changes in the striatum of the nicotine abstinence mouse. Nicotine 72-80 pro-opiomelanocortin-alpha Mus musculus 0-14 8923511-0 1996 Nicotine enhances morphine- and beta-endorphin-induced antinociception at the supraspinal level in the mouse. Nicotine 0-8 pro-opiomelanocortin-alpha Mus musculus 32-46 8923511-7 1996 The degree of enhancing effect of nicotine toward beta-endorphin-induced inhibition of the tail-flick response was greater than toward morphine-induced inhibition of the tail-flick response. Nicotine 34-42 pro-opiomelanocortin-alpha Mus musculus 50-64 10996137-0 2000 Glutamate receptors participate in the nicotine-induced changes of met-enkephalin in striatum. Nicotine 39-47 pro-opiomelanocortin-alpha Mus musculus 67-81 10996137-1 2000 A single dose of nicotine given to mice induces first a rapid decrease (presumed release/enhanced degradation) and then a rise (presumed synthesis/enhanced accumulation) of met-enkephalin (Met-Enk) in dorsal and ventral striatum observed at 30 and 60 min post-treatment, respectively. Nicotine 17-25 pro-opiomelanocortin-alpha Mus musculus 173-187