PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33432238-0	2021	A cytochrome c is the natural electron acceptor for nicotine oxidoreductase.	Nicotine	52-60	cytochrome c, somatic	Homo sapiens	2-14	
29972271-7	2018	Simultaneously, nicotine induces pancreatic islet cell apoptosis by modulating DeltaPsim via increased cytosolic Ca2+ level, altered Bcl-2, Bax, cytochrome c, caspase-9, PARP expressions which were prevented by the supplementation of folic acid and vitamin B12 .	Nicotine	16-24	cytochrome c, somatic	Homo sapiens	145-157	
33542535-0	2021	Author Correction: A cytochrome c is the natural electron acceptor for nicotine oxidoreductase.	Nicotine	71-79	cytochrome c, somatic	Homo sapiens	21-33	
29058303-4	2017	Despite the increased diffusion, nicotine in combination with TOB significantly increased mucosal cell survival (p < 0.05) by reducing the release of mitochondrial cytochrome c into the cytoplasm when compared with nicotine without TOB.	Nicotine	33-41	cytochrome c, somatic	Homo sapiens	167-179	
29058303-5	2017	The average percentage distribution of cytochrome c in the cytosolic fraction over time of nicotine + 79% ethyl alcohol (ETOH) versus nicotine plus TOB (79% ETOH) was significantly different over 120 min (60.0 +- 29.9% cytosol, 16.1 +- 9.4% cytosol, p = 0.03).	Nicotine	91-99	cytochrome c, somatic	Homo sapiens	39-51	
29058303-7	2017	CONCLUSION: Two hours of TOB (17-24% benzoin, 79% ETOH) plus nicotine promotes diffusion of nicotine across human mucosal cells and simultaneously prevents human mucosal cell toxicity by inhibiting cytochrome c release into the cytosol, thereby preventing caspase 3 and 9 activity and subsequent intrinsic apoptosis.	Nicotine	61-69	cytochrome c, somatic	Homo sapiens	198-210	
27770269-2	2017	The pro-apoptotic p66shc protein-via serine36 phosphorylation that facilitates its mitochondrial translocation and therein cytochrome c binding-generates oxidative stress that leads to injury of renal proximal tubule cells during chronic nicotine exposure.	Nicotine	238-246	cytochrome c, somatic	Homo sapiens	123-135	
25998908-7	2015	Nicotine abolished PVIgG-dependent CytC release, showing a dose-dependent effect, suggesting that protection of mitochondria can be a novel mechanism of therapeutic action of nicotinic agonists in PV.	Nicotine	0-8	cytochrome c, somatic	Homo sapiens	35-39	
11701223-5	2001	The inhibition of apoptosis by nicotine was correlated with the prevention of cytochrome c release and caspase activation, which are essential components of the UV-induced apoptotic pathway.	Nicotine	31-39	cytochrome c, somatic	Homo sapiens	78-90	
15985439-2	2005	By using isolated brain mitochondria, we found that nicotine inhibited N-methyl-4-phenylpyridine (MPP(+)) and calcium-induced mitochondria high amplitude swelling and cytochrome c release from intact mitochondria.	Nicotine	52-60	cytochrome c, somatic	Homo sapiens	167-179	
11238724-0	2001	Nicotine protects against arachidonic-acid-induced caspase activation, cytochrome c release and apoptosis of cultured spinal cord neurons.	Nicotine	0-8	cytochrome c, somatic	Homo sapiens	71-83