PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10530917-4	1999	IL-1 beta concentrations increased by 2.6, 2.7 and 7.5 times those of the control in groups treated with 1 microM nicotine, arecoline or with both, respectively.	Nicotine	114-122	interleukin 1 beta	Homo sapiens	0-9	
12132790-13	2002	This is against the hypothesis that nicotine exerts a direct pro-inflammatory action via interleukin-1beta and interleukin-8.	Nicotine	36-44	interleukin 1 beta	Homo sapiens	89-106	
15454119-0	2004	Nicotine could augment adhesion molecule expression in human endothelial cells through macrophages secreting TNF-alpha, IL-1beta.	Nicotine	0-8	interleukin 1 beta	Homo sapiens	120-128	
15454119-7	2004	The results showed TNF-alpha, IL-1beta could reach the peak with 0.06mM nicotine treated for 24 and 12 h on Ana-1, respectively, but IL-8 and IFN-gamma had no significant alter.	Nicotine	72-80	interleukin 1 beta	Homo sapiens	30-38	
15454119-11	2004	In conclusion, our findings suggest that nicotine could augment macrophages releasing TNF-alpha and IL-1beta, furthermore TNF-alpha and IL-1beta could up-regulate the expression of adhesion molecule and increase adhesion of monocytes to HUVECs.	Nicotine	41-49	interleukin 1 beta	Homo sapiens	100-108	
34601327-0	2021	In-vitro immunomodulatory effects of nicotine on Nitric Oxide, interleukin 1beta and interleukin 37 production in human peripheral blood mononuclear cells (PBMC) from patients with Behcet disease.	Nicotine	37-45	interleukin 1 beta	Homo sapiens	63-80	
8708946-0	1996	Nicotine effects on PGE2 and IL-1 beta release by LPS-treated human monocytes.	Nicotine	0-8	interleukin 1 beta	Homo sapiens	29-38	
8708946-10	1996	IL-1 beta secretion was lower for either LPS plus 100 micrograms/ml nicotine relative to LPS alone, although not significantly.	Nicotine	68-76	interleukin 1 beta	Homo sapiens	0-9	
34601327-2	2021	In our current study we sought to evaluate the in-vitro modulatory effect of nicotine, the principal alkaloid of tobacco, on nitric oxide (NO), interleukin 1beta (IL-1beta) and interleukin 37 (IL-37) production during Behcet"s disease.	Nicotine	77-85	interleukin 1 beta	Homo sapiens	144-161	
27681882-0	2016	Immunomodulatory effects of nicotine on interleukin 1beta activated human astrocytes and the role of cyclooxygenase 2 in the underlying mechanism.	Nicotine	28-36	interleukin 1 beta	Homo sapiens	40-57	
35285601-0	2022	Whole Salivary Cotinine Levels and Interleukin 1-beta Levels among Young Adults Involuntarily Exposed to Vapor from Electronic Nicotine Delivery Systems.	Nicotine	127-135	interleukin 1 beta	Homo sapiens	35-53	
30030777-6	2019	Nicotine, 4-NQO, and their combinational applications with Pg LPS induced the secretions of IL-1beta and IL-1Ra, while that of IL-8 was inhibited by the presence of Pg LPS.	Nicotine	0-8	interleukin 1 beta	Homo sapiens	92-100	
29416034-7	2018	Moreover, silencing NLRP3 or ASC by small interfering RNA efficiently suppressed nicotine-induced caspase-1 cleavage, IL-18 and IL-1beta production, and pyroptosis in HAECs.	Nicotine	81-89	interleukin 1 beta	Homo sapiens	128-136	
27984197-5	2017	The results indicated that chronic nicotine administration (0.1mg/kg, s.c., 14days) inhibited the LPS-induced nuclear binding of NF-kappaB and mRNA expression levels of Tnf, Il1b, Nos2, and Tlr4.	Nicotine	35-43	interleukin 1 beta	Homo sapiens	174-178	
27681882-4	2016	Here, we investigated the effects of nicotine, an ACh receptor agonist, on the cytokine and cholinesterase production of immunocompetent human astrocytes stimulated with interleukin 1beta (IL-1beta) in vitro.	Nicotine	37-45	interleukin 1 beta	Homo sapiens	170-187	
27681882-4	2016	Here, we investigated the effects of nicotine, an ACh receptor agonist, on the cytokine and cholinesterase production of immunocompetent human astrocytes stimulated with interleukin 1beta (IL-1beta) in vitro.	Nicotine	37-45	interleukin 1 beta	Homo sapiens	189-197	
27681882-11	2016	RESULTS: Nicotine treatment dose dependently limits the production of critical proinflammatory cytokines such as IL-6 (60.5 +- 3.3, %inhibition), IL-1beta (42.4 +- 1.7, %inhibition), and TNF-alpha (68.9 +- 7.7, %inhibition) by activated human astrocytes.	Nicotine	9-17	interleukin 1 beta	Homo sapiens	146-154	
25858413-0	2015	A functional polymorphism in the interleukin-1beta and severity of nicotine dependence in male schizophrenia: a case-control study.	Nicotine	67-75	interleukin 1 beta	Homo sapiens	33-50	
26553320-10	2016	Compared with the monoculture, MMP-1, MMP-3, interleukin (IL)-1beta, IL-6, IL-17, and IL-21 in supernatant of cocultures were markedly elevated after treatment with nicotine.	Nicotine	165-173	interleukin 1 beta	Homo sapiens	45-67	
26364593-6	2016	IL-1beta had a positive correlation with nicotine (r = 0.351) and the cotinine (r = 0.376), nicotine (r = 0.492) and hydroxycotinine (r = 0.358), and hydroxycotinine (r = 0.413) levels at 2 wk and 4 and 6 mo follow-up, respectively.	Nicotine	41-49	interleukin 1 beta	Homo sapiens	0-8	
26364593-6	2016	IL-1beta had a positive correlation with nicotine (r = 0.351) and the cotinine (r = 0.376), nicotine (r = 0.492) and hydroxycotinine (r = 0.358), and hydroxycotinine (r = 0.413) levels at 2 wk and 4 and 6 mo follow-up, respectively.	Nicotine	92-100	interleukin 1 beta	Homo sapiens	0-8	
26364593-7	2016	CONCLUSIONS: This 1-year prospective smoking cessation study without nonsurgical periodontal therapy shows IL-1beta in gingival crevicular fluid could have a positive relationship with the nicotine and cotinine levels in saliva.	Nicotine	189-197	interleukin 1 beta	Homo sapiens	107-115	
26334245-9	2015	Pharmacologic and siRNA-mediated inhibition of PLD1 and PLD2 attenuated the nicotine- and LPS-induced upregulation of inducible nitric oxide (NO) synthase and cyclooxygenase-2, production of NO, and prostaglandin E2, and mRNA expression and secretion of tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-8.	Nicotine	76-84	interleukin 1 beta	Homo sapiens	283-305	
26209886-4	2015	The PBMC treatment with PHA plus nicotine produced a significant decrease of IL-1beta e IL-17 both as transcript and as protein, confirming that the PBMC of the patients respond to the cholinergic stimulation more than PBMC of HD.	Nicotine	33-41	interleukin 1 beta	Homo sapiens	77-85	
25858413-10	2015	Our findings suggest that the IL-1beta-511C/T polymorphism may not be related to schizophrenia or smoking status in Chinese individuals, but may affect the severity of nicotine dependence among male smokers with schizophrenia.	Nicotine	168-176	interleukin 1 beta	Homo sapiens	30-38	
25059554-0	2014	Nicotine induces the production of IL-1beta and IL-8 via the alpha7 nAChR/NF-kappaB pathway in human periodontal ligament cells: an in vitro study.	Nicotine	0-8	interleukin 1 beta	Homo sapiens	35-43	
25204733-5	2015	In a human OSCC cell line TW2.6, we demonstrated nicotine-derived nitrosamine ketone (NNK) and arecoline stimulated IL-1beta secretion in an inflammasome-dependent manner.	Nicotine	49-57	interleukin 1 beta	Homo sapiens	116-124	
25059554-6	2014	RESULTS: Compared with the control group, nicotine could significantly induce production of IL-1beta and IL-8 in human PDL cells and cause the similar effects on the expression of the NF-kappaB p65 subunit and NF-kappaB activity.	Nicotine	42-50	interleukin 1 beta	Homo sapiens	92-100	
25059554-7	2014	CONCLUSION: This study demonstrates that nicotine could induce production of IL-1beta and IL-8 via the alpha7 nAChR/NF-kappaB pathway in human PDL cells, providing data for a better understanding of the relationships among smoking, nicotine, and periodontitis.	Nicotine	41-49	interleukin 1 beta	Homo sapiens	77-85	
25059554-7	2014	CONCLUSION: This study demonstrates that nicotine could induce production of IL-1beta and IL-8 via the alpha7 nAChR/NF-kappaB pathway in human PDL cells, providing data for a better understanding of the relationships among smoking, nicotine, and periodontitis.	Nicotine	232-240	interleukin 1 beta	Homo sapiens	77-85	
23994388-0	2013	Long-term nicotine treatment suppresses IL-1beta release and attenuates substance P- and 5-HT-evoked Ca2+ responses in astrocytes.	Nicotine	10-18	interleukin 1 beta	Homo sapiens	40-48	
23994388-1	2013	The aim of this study was to investigate whether short- or long-term nicotine treatment, had an influence on Ca(2+)-induced intracellular Ca(2+) release in astrocytes co-cultured with microvascular endothelial cells, and if the release of interleukin-1beta (IL-1beta) changed during this treatment.	Nicotine	69-77	interleukin 1 beta	Homo sapiens	239-256	
23994388-1	2013	The aim of this study was to investigate whether short- or long-term nicotine treatment, had an influence on Ca(2+)-induced intracellular Ca(2+) release in astrocytes co-cultured with microvascular endothelial cells, and if the release of interleukin-1beta (IL-1beta) changed during this treatment.	Nicotine	69-77	interleukin 1 beta	Homo sapiens	258-266	
23994388-5	2013	The results show that long-term nicotine treatment had no influence on nicotine-evoked Ca(2+) transients or protein expression of the alpha7-nAChR, but had with a decreased IL-1beta release.	Nicotine	32-40	interleukin 1 beta	Homo sapiens	173-181	
22119045-0	2012	Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1beta or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling.	Nicotine	0-8	interleukin 1 beta	Homo sapiens	100-108	
24028591-8	2013	The concentrations of SP and IL-1beta were significantly increased in cells incubated with NEP inhibitors and, to a lesser extent, in cells incubated with ECE-1/NEP inhibitors, compared with controls (cells incubated with LPS or nicotine alone).	Nicotine	229-237	interleukin 1 beta	Homo sapiens	29-37	
23443505-0	2013	Nicotine favors osteoclastogenesis in human periodontal ligament cells co-cultured with CD4(+) T cells by upregulating IL-1beta.	Nicotine	0-8	interleukin 1 beta	Homo sapiens	119-127	
23443505-8	2013	Compared with mono-culture systems, stimulation with nicotine caused an increased secretion of IL-1beta in serum of human PDL cell-CD4(+) T cell co-culture, and the expression of RANKL in human PDL cells was further upregulated co-cultured with CD4(+) T cells, while no differences were observed in the expression of OPG between the co-culture and mono-culture systems.	Nicotine	53-61	interleukin 1 beta	Homo sapiens	95-103	
23443505-9	2013	Our data suggested that nicotine upregulated IL-1beta secretion, further upregulated RANKL expression in smoking-associated periodontitis, which may aid in the better understanding of the relationship between nicotine and alveolar bone resorption.	Nicotine	24-32	interleukin 1 beta	Homo sapiens	45-53	
23443505-9	2013	Our data suggested that nicotine upregulated IL-1beta secretion, further upregulated RANKL expression in smoking-associated periodontitis, which may aid in the better understanding of the relationship between nicotine and alveolar bone resorption.	Nicotine	209-217	interleukin 1 beta	Homo sapiens	45-53	
22119045-8	2012	Nicotine increased the secretion of IL-8 from HGECs that were cultured in the presence of IL-1beta or P. gingivalis LPS and also induced the phosphorylation of extracellular signal-regulated kinase (ERK) in epi 4.	Nicotine	0-8	interleukin 1 beta	Homo sapiens	90-98	
20309583-8	2010	The expressions of alpha 7 nAChR and IL-1 beta were significantly increased by nicotine administration, whereas alpha-Btx treatment partially suppressed these effects.	Nicotine	79-87	interleukin 1 beta	Homo sapiens	37-46	
19729077-6	2009	Apigenin significantly inhibited the nicotine- and LPS-induced production of NO, PGE2, IL-1beta, TNF-alpha, IL-6, and IL-12, and the upregulation of iNOS and COX-2 in hPDL cells.	Nicotine	37-45	interleukin 1 beta	Homo sapiens	87-95	
19732285-6	2009	Nicotine suppresses IL-1beta and IL-6 expression at least in part by inhibiting NFkappaB activation.	Nicotine	0-8	interleukin 1 beta	Homo sapiens	20-28	
18618634-8	2008	In all groups, nicotine reduced LPS- and PHA (0.5 microg/mL)-stimulated production of IL1beta, IL10, TGFbeta, and TNFalpha (P < 0.001).	Nicotine	15-23	interleukin 1 beta	Homo sapiens	86-93