PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29195920-0 2018 Loss of Lypd6 leads to reduced anxiety-like behaviour and enhanced responses to nicotine. Nicotine 80-88 LY6/PLAUR domain containing 6 Mus musculus 8-13 19403274-3 2009 Lypd6 overexpressed in trigeminal ganglia neurons selectively enhanced the Ca2+-component of nicotine-evoked currents through nAChRs, as evidenced by comparative whole-cell patch clamp recordings and Ca2+-imaging in wildtype and transgenic mice overexpressing Lypd6. Nicotine 93-101 LY6/PLAUR domain containing 6 Mus musculus 0-5 19403274-3 2009 Lypd6 overexpressed in trigeminal ganglia neurons selectively enhanced the Ca2+-component of nicotine-evoked currents through nAChRs, as evidenced by comparative whole-cell patch clamp recordings and Ca2+-imaging in wildtype and transgenic mice overexpressing Lypd6. Nicotine 93-101 LY6/PLAUR domain containing 6 Mus musculus 260-265 19403274-4 2009 In contrast, a knockdown of Lypd6 expression using siRNAs selectively reduced nicotine-evoked Ca2+-currents. Nicotine 78-86 LY6/PLAUR domain containing 6 Mus musculus 28-33 19403274-7 2009 These mice overexpressing Lypd6 mice were also more sensitive to the analgesic effects of nicotine. Nicotine 90-98 LY6/PLAUR domain containing 6 Mus musculus 26-31 29195920-7 2018 Using in vitro electrophysiology in dorsal raphe nuclei (DRN) neurons from Lypd6 KO mice, we show that nicotine-evoked whole-cell currents are enhanced in the absence of Lypd6. Nicotine 103-111 LY6/PLAUR domain containing 6 Mus musculus 75-80