PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24478678-1 2014 The CHRNA5-CHRNA3-CHRNB4 gene cluster, encoding the alpha5, alpha3, and beta4 nicotinic acetylcholine receptor (nAChR) subunits, has been linked to nicotine dependence. Nicotine 148-156 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 11-17 33380469-1 2021 Allelic variation in CHRNA3, the gene encoding the alpha3 nicotinic acetylcholine receptor (nAChR) subunit, increases vulnerability to tobacco dependence and smoking-related diseases, but little is known about the role for alpha3-containing (alpha3*) nAChRs in regulating the addiction-related behavioral or physiological actions of nicotine. Nicotine 333-341 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 21-27 33380469-3 2021 We found that Chrna3tm1.1Hwrt hypomorphic mice, which express constitutively low levels of alpha3* nAChRs, self-administer greater quantities of nicotine (0.4 mg kg-1 per infusion) than their wild-type littermates. Nicotine 145-153 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 91-98 33380469-10 2021 We report that Chrna3 hypomorphic mice consume greater quantities of nicotine than wild-type mice and that knockdown of Chrna3 gene transcripts in the habenula or interpeduncular nucleus (IPn) increases nicotine intake in rats. Nicotine 203-211 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 120-126 25051446-7 2014 Chronic nicotine treatment significantly suppressed expression of alpha3-nAChR (predominant peripheral alpha-subunit) in liver. Nicotine 8-16 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 66-72 12594236-0 2003 Central role of fibroblast alpha3 nicotinic acetylcholine receptor in mediating cutaneous effects of nicotine. Nicotine 101-109 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 27-33 11450844-2 2001 Mice lacking the alpha3 subunit and mice lacking both the beta2 and beta4 subunits, but not mice lacking the beta2 or beta4 subunits alone, have a severe phenotype characterized by megacystis, failure of bladder strips to contract in response to nicotine, widely dilated ocular pupils, growth failure, and perinatal mortality. Nicotine 246-254 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 17-23 1705971-5 1991 The alpha 2 beta 2 combination was 5-fold more sensitive to nicotine than to acetylcholine, while the alpha 3 beta 2 combination was 17-fold less sensitive to nicotine than to ACh, and the alpha 3 beta 4 combination was equally sensitive to both nicotine and ACh. Nicotine 159-167 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 102-109 1705971-5 1991 The alpha 2 beta 2 combination was 5-fold more sensitive to nicotine than to acetylcholine, while the alpha 3 beta 2 combination was 17-fold less sensitive to nicotine than to ACh, and the alpha 3 beta 4 combination was equally sensitive to both nicotine and ACh. Nicotine 159-167 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 102-109 29293602-11 2018 Giving nicotine (100 mug/ml) in drinking water to WT mice for 3 weeks differentially increased the expression of alpha3, alpha4, alpha5, alpha6, alpha7, beta2 and beta4 mRNAs in circumvallate TRCs to varying degrees. Nicotine 7-15 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 113-151 27638450-8 2016 Interestingly, these nocifensive behavior alterations and differential responses to nicotine antinociceptive effects in BTBR mice were associated with significant downregulation of alpha3, alpha4, alpha5, alpha7, beta2, beta3, and beta4 nAChR subunits in several cerebral regions both, during embryonic development and adulthood. Nicotine 84-92 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 181-211 24478678-1 2014 The CHRNA5-CHRNA3-CHRNB4 gene cluster, encoding the alpha5, alpha3, and beta4 nicotinic acetylcholine receptor (nAChR) subunits, has been linked to nicotine dependence. Nicotine 148-156 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 60-66 16622038-0 2006 Differential regulation of mesolimbic alpha 3/alpha 6 beta 2 and alpha 4 beta 2 nicotinic acetylcholine receptor sites and function after long-term oral nicotine to monkeys. Nicotine 153-161 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 38-45 23545467-6 2013 In the medial habenula, alpha5-containing, alpha3-containing, and beta4-containing nAChRs were shown to be crucially important in the regulation of the aversive aspects of nicotine. Nicotine 172-180 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 43-49 21555077-1 2011 Nicotine dependence is linked to single nucleotide polymorphisms in the CHRNB4-CHRNA3-CHRNA5 gene cluster encoding the alpha3beta4alpha5 nicotinic acetylcholine receptor (nAChR). Nicotine 0-8 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 79-85 16622038-3 2006 We determined the effects of nicotine treatment on function and binding of the alpha3/alpha6beta2* and alpha4beta2* nAChRs subtypes in nucleus accumbens, a region directly implicated in the addictive effects of nicotine. Nicotine 29-37 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 79-97 16622038-3 2006 We determined the effects of nicotine treatment on function and binding of the alpha3/alpha6beta2* and alpha4beta2* nAChRs subtypes in nucleus accumbens, a region directly implicated in the addictive effects of nicotine. Nicotine 211-219 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 79-97 16622038-8 2006 Thus, these data are distinct from previous results in striatum in which the same nicotine treatment paradigm decreased striatal alpha3/alpha6beta2* nAChR sites and function. Nicotine 82-90 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 129-147 15275829-0 2004 The alpha3 and beta4 nicotinic acetylcholine receptor subunits are necessary for nicotine-induced seizures and hypolocomotion in mice. Nicotine 81-89 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 4-10 15275829-7 2004 alpha3 +/- mice were partially resistant to nicotine-induced seizures when compared to wild-type littermates. Nicotine 44-52 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 0-6 15275829-9 2004 Together, these results suggest that the beta4 and the alpha3 subunits are mediators of nicotine-induced seizures and hypolocomotion. Nicotine 88-96 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 55-61