PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29215713-0	2018	Nicotine increases colon cancer cell migration and invasion through epithelial to mesenchymal transition (EMT): COX-2 involvement.	Nicotine	0-8	cox2	Nicotiana tabacum	112-117	
29215713-3	2018	In both these cell lines, treatment with nicotine increased COX-2 expression and the release of its enzymatic product PGE2 .	Nicotine	41-49	cox2	Nicotiana tabacum	60-65	
29215713-5	2018	Noticeably, all these effects are largely mediated by COX-2 activity, as simultaneous treatment of both cell lines with nicotine and NS-398, a selective COX-2 inhibitor, greatly reduced the number of migrating and invading cells and reverted nicotine-induced EMT.	Nicotine	120-128	cox2	Nicotiana tabacum	54-59	
29215713-5	2018	Noticeably, all these effects are largely mediated by COX-2 activity, as simultaneous treatment of both cell lines with nicotine and NS-398, a selective COX-2 inhibitor, greatly reduced the number of migrating and invading cells and reverted nicotine-induced EMT.	Nicotine	120-128	cox2	Nicotiana tabacum	153-158	
29215713-5	2018	Noticeably, all these effects are largely mediated by COX-2 activity, as simultaneous treatment of both cell lines with nicotine and NS-398, a selective COX-2 inhibitor, greatly reduced the number of migrating and invading cells and reverted nicotine-induced EMT.	Nicotine	242-250	cox2	Nicotiana tabacum	54-59	
29215713-7	2018	Thereby, the use of COX-2 inhibitor drugs might likely counteract nicotine-mediated EMT effects on colon cancer development and progression.	Nicotine	66-74	cox2	Nicotiana tabacum	20-25