PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15964916-2	2005	We examined whether nicotine regulates angiotensin-converting enzyme (ACE), an enzyme that plays an important role in the pathophysiology of atherosclerosis and hypertension.	Nicotine	20-28	angiotensin I converting enzyme	Homo sapiens	70-73	
15964916-6	2005	Nicotine did not modulate basal ACE production but significantly potentiated VEGF-induced ACE upregulation.	Nicotine	0-8	angiotensin I converting enzyme	Homo sapiens	90-93	
15964916-7	2005	Treatment of endothelial cells with the PKC inhibitor GFX totally blocked VEGF- and nicotine-induced ACE upregulation.	Nicotine	84-92	angiotensin I converting enzyme	Homo sapiens	101-104	
15964916-9	2005	We conclude that nicotine significantly potentiated VEGF-induced ACE upregulation.	Nicotine	17-25	angiotensin I converting enzyme	Homo sapiens	65-68	
15964916-11	2005	The interaction of nicotine with VEGF in ACE induction may contribute to the pathogenesis of smoking-related cardiovascular disease.	Nicotine	19-27	angiotensin I converting enzyme	Homo sapiens	41-44	
11166759-3	2001	Treatment of primary human coronary artery endothelial cells with nicotine for 24 h at concentrations (10(-5) and 10(-7) M) similar to those in the blood of smokers resulted in increased mRNA levels of endothelial nitric oxide synthase, angiotensin-I converting enzyme, tissue-type plasminogen activator, plasminogen activator inhibitor-1, von Willebrand factor, and vascular cell adhesion molecule-1.	Nicotine	66-74	angiotensin I converting enzyme	Homo sapiens	237-268	
33123372-3	2020	In the present study, the association between an insertion/deletion (I/D) polymorphism of ACE and nicotine dependence amongst patients with lung cancer was assessed.	Nicotine	98-106	angiotensin I converting enzyme	Homo sapiens	90-93	
28028641-1	2017	We investigated the relationship between the functional insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene and the risk of nicotine dependence in Croatian schizophrenia patients.	Nicotine	158-166	angiotensin I converting enzyme	Homo sapiens	101-130	
28028641-1	2017	We investigated the relationship between the functional insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene and the risk of nicotine dependence in Croatian schizophrenia patients.	Nicotine	158-166	angiotensin I converting enzyme	Homo sapiens	132-135	
28028641-8	2017	This is the first study to investigate the possible association between ACE-I/D polymorphism and nicotine dependence in schizophrenia.	Nicotine	97-105	angiotensin I converting enzyme	Homo sapiens	72-75	
28028641-9	2017	Our results suggest that the ACE-I/D polymorphism may be relevant in determining the risk of nicotine dependence in female patients with schizophrenia while the ACE genotype-smoking interaction does not contribute to the clinical expression of schizophrenia.	Nicotine	93-101	angiotensin I converting enzyme	Homo sapiens	29-32	
28127518-10	2017	In the context of reports on the ACE-I/D polymorphism and nicotine dependence among healthy controls and patients with depression, we may speculate that the mechanism by which this polymorphism influences nicotine dependence risk differs in MS compared to depression, although not compared to a healthy population.	Nicotine	205-213	angiotensin I converting enzyme	Homo sapiens	33-36	
19065315-0	2008	Effect of nicotine and nicotine metabolites on angiotensin-converting enzyme in human endothelial cells.	Nicotine	10-18	angiotensin I converting enzyme	Homo sapiens	47-76	
19065315-0	2008	Effect of nicotine and nicotine metabolites on angiotensin-converting enzyme in human endothelial cells.	Nicotine	23-31	angiotensin I converting enzyme	Homo sapiens	47-76	
19065315-7	2008	The results showed that nicotine and nicotine metabolites can increase both activity and expression of ACE.	Nicotine	24-32	angiotensin I converting enzyme	Homo sapiens	103-106	
19065315-7	2008	The results showed that nicotine and nicotine metabolites can increase both activity and expression of ACE.	Nicotine	37-45	angiotensin I converting enzyme	Homo sapiens	103-106