PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24621512-0 2014 Nicotine activates YAP1 through nAChRs mediated signaling in esophageal squamous cell cancer (ESCC). Nicotine 0-8 Yes1 associated transcriptional regulator Homo sapiens 19-23 32894161-11 2020 CONCLUSIONS: These data demonstrate that YAP1 enhances nicotine-stimulated EMT and tumor progression of PDAC through a HIF1A/YAP1 positive feedback loop. Nicotine 55-63 Yes1 associated transcriptional regulator Homo sapiens 125-129 32894161-0 2020 A nicotine-induced positive feedback loop between HIF1A and YAP1 contributes to epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma. Nicotine 2-10 Yes1 associated transcriptional regulator Homo sapiens 60-64 32894161-8 2020 In term of mechanism, hypoxia inducible factor (HIF)1A promoted YAP1 nuclear localization and YAP1 transactivation by directly binding to the hypoxia responsive elements of the YAP1 promoter upon nicotine treatment. Nicotine 196-204 Yes1 associated transcriptional regulator Homo sapiens 64-68 32894161-8 2020 In term of mechanism, hypoxia inducible factor (HIF)1A promoted YAP1 nuclear localization and YAP1 transactivation by directly binding to the hypoxia responsive elements of the YAP1 promoter upon nicotine treatment. Nicotine 196-204 Yes1 associated transcriptional regulator Homo sapiens 94-98 32894161-8 2020 In term of mechanism, hypoxia inducible factor (HIF)1A promoted YAP1 nuclear localization and YAP1 transactivation by directly binding to the hypoxia responsive elements of the YAP1 promoter upon nicotine treatment. Nicotine 196-204 Yes1 associated transcriptional regulator Homo sapiens 94-98 32894161-9 2020 Nicotine stimulated HIF1A and YAP1 expression by activating cholinergic receptor nicotinic alpha7 (CHRNA7). Nicotine 0-8 Yes1 associated transcriptional regulator Homo sapiens 30-34 32894161-11 2020 CONCLUSIONS: These data demonstrate that YAP1 enhances nicotine-stimulated EMT and tumor progression of PDAC through a HIF1A/YAP1 positive feedback loop. Nicotine 55-63 Yes1 associated transcriptional regulator Homo sapiens 41-45 24621512-3 2014 In this study, we find nicotine administration can induce nuclear translocation and activation of YAP1 in ESCC. Nicotine 23-31 Yes1 associated transcriptional regulator Homo sapiens 98-102 24621512-4 2014 Consistently, we observed nuclear translocation and activation of YAP1 by knockdown of CHRNA3, which is a negative regulator of nicotine signaling in bronchial and esophageal cancer cells. Nicotine 128-136 Yes1 associated transcriptional regulator Homo sapiens 66-70 24621512-7 2014 This process likely requires PKC activation, as PKC specific inhibitor Enzastaurin can block nicotine induced YAP1 activation. Nicotine 93-101 Yes1 associated transcriptional regulator Homo sapiens 110-114 24621512-8 2014 In addition, we find nicotine signaling also inhibits the interaction of YAP1 with P63, which contributes to the inhibitory effect of nicotine on apoptosis. Nicotine 21-29 Yes1 associated transcriptional regulator Homo sapiens 73-77 24621512-8 2014 In addition, we find nicotine signaling also inhibits the interaction of YAP1 with P63, which contributes to the inhibitory effect of nicotine on apoptosis. Nicotine 134-142 Yes1 associated transcriptional regulator Homo sapiens 73-77 24621512-11 2014 Together, these findings suggest that the nicotine activated nAChRs signaling pathway which further activates YAP1 plays an important role in the development of esophageal cancer, and this mechanism may be of a general significance for the carcinogenesis of smoking related cancers. Nicotine 42-50 Yes1 associated transcriptional regulator Homo sapiens 110-114