PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27976742-6 2016 In the fetuses, decreased body weight and organ index of fetal thymus, histological changes in fetal thymus, reduced CD4SP proportion and increased fetal thymocyte apoptosis were observed in nicotine group. Nicotine 191-199 CD4 antigen Mus musculus 117-120 32927162-11 2021 In addition, nicotine-inhibited CD69-CD4+SP cells and the Bcl10/p-p65 pathway have been reversed by an autophagy inhibitor. Nicotine 13-21 CD4 antigen Mus musculus 37-40 25742430-0 2015 Nicotine ameliorates experimental severe acute pancreatitis via enhancing immunoregulation of CD4+ CD25+ regulatory T cells. Nicotine 0-8 CD4 antigen Mus musculus 94-97 25742430-10 2015 Moreover, nicotine up-regulated the number and suppressive capacity of CD4 CD25 Treg via inducing the expression of immunoregulatory molecules and transforming growth factor beta1 elevation. Nicotine 10-18 CD4 antigen Mus musculus 71-74 24107512-5 2014 In the circulation, spleen, bone marrow, and thymus, we find that nicotine promotes an increase in CD3(+)CD4(+) cells via its activation of the alpha4 nAChR and regulation of G protein subunit o, G protein regulated-inducer of neurite outgrowth, and CDC42 signaling within T cells. Nicotine 66-74 CD4 antigen Mus musculus 105-108 24583006-8 2014 Immunization of mice with a synthetic nicotine nanoparticle vaccine containing TpD showed that the peptide was required for robust antibody production and resulted in a long term CD4 memory T cell recall response. Nicotine 38-46 CD4 antigen Mus musculus 179-182 21784975-0 2011 Cytokine-induced alterations of alpha7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis. Nicotine 113-121 CD4 antigen Mus musculus 69-72 21784975-7 2011 TCR stimulation of naive CD4(+)CD62L(+) T cells in the presence of nicotine upregulated expression of Foxp3. Nicotine 67-75 CD4 antigen Mus musculus 25-28 21784975-8 2011 In marked contrast, nicotine worsened TNBS colitis, and this was associated with increased Th17 cells among colonic CD4 T cells. Nicotine 20-28 CD4 antigen Mus musculus 116-119 21784975-10 2011 The dichotomous action of nicotine resulted from the up- and downregulation of anti-inflammatory alpha7 nAChR on colonic CD4 T cells induced by cytokines characteristic of the inflammatory milieu in oxazolone (IL-4) and TNBS (IL-12) colitis, respectively. Nicotine 26-34 CD4 antigen Mus musculus 121-124 20843956-0 2010 Stimulation of alpha7 nicotinic acetylcholine receptor by nicotine increases suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro. Nicotine 58-66 CD4 antigen Mus musculus 121-124 20843956-4 2010 We found that CD4(+)CD25(+) Tregs from naive C57BL/6J mice positively expressed alpha7 nAChR, and its activation by nicotine enhanced the suppressive capacity of Tregs. Nicotine 116-124 CD4 antigen Mus musculus 14-17 20843956-6 2010 In the supernatants of CD4(+)CD25(+) Tregs/CD4(+)CD25(-) T-cell cocultures, we observed a decrease in the concentration of IL-2 in nicotine-stimulated groups, but nicotine stimulation had no effect on the ratio of IL-4/interferon (IFN)-gamma, which partially represented T-cell polarization. Nicotine 131-139 CD4 antigen Mus musculus 23-26 20843956-6 2010 In the supernatants of CD4(+)CD25(+) Tregs/CD4(+)CD25(-) T-cell cocultures, we observed a decrease in the concentration of IL-2 in nicotine-stimulated groups, but nicotine stimulation had no effect on the ratio of IL-4/interferon (IFN)-gamma, which partially represented T-cell polarization. Nicotine 131-139 CD4 antigen Mus musculus 43-46 20843956-6 2010 In the supernatants of CD4(+)CD25(+) Tregs/CD4(+)CD25(-) T-cell cocultures, we observed a decrease in the concentration of IL-2 in nicotine-stimulated groups, but nicotine stimulation had no effect on the ratio of IL-4/interferon (IFN)-gamma, which partially represented T-cell polarization. Nicotine 163-171 CD4 antigen Mus musculus 23-26 20843956-6 2010 In the supernatants of CD4(+)CD25(+) Tregs/CD4(+)CD25(-) T-cell cocultures, we observed a decrease in the concentration of IL-2 in nicotine-stimulated groups, but nicotine stimulation had no effect on the ratio of IL-4/interferon (IFN)-gamma, which partially represented T-cell polarization. Nicotine 163-171 CD4 antigen Mus musculus 43-46 19846875-11 2009 In vivo, administration of nicotine (2 mg/kg s.c.) suppressed the severity of CD4(+) T cell-mediated disease experimental autoimmune encephalomyelitis. Nicotine 27-35 CD4 antigen Mus musculus 78-81 9023586-0 1996 The effect of nicotine on murine CD4 T cell responses. Nicotine 14-22 CD4 antigen Mus musculus 33-36 9023586-5 1996 Exposure to nicotine decreased the percentage of CD4+ T cells expressing both CD28 and CTLA-4 and decreased the intensity of CD28 expression. Nicotine 12-20 CD4 antigen Mus musculus 49-52 9023586-8 1996 Thus, exposure of T cells to physiological concentrations of STE or nicotine can alter the T cell expression of CD28 and CTLA-4, and the CD4 T cell cytokine expression pattern. Nicotine 68-76 CD4 antigen Mus musculus 137-140 35533447-0 2022 Asthma susceptibility in prenatal nicotine-exposed mice attributed to beta-catenin increase during CD4+ T cell development. Nicotine 34-42 CD4 antigen Mus musculus 99-102 35533447-3 2022 Our previous studies demonstrated that prenatal exposure to nicotine (PNE), the major active product of smoking, impairs fetal thymopoiesis and CD4+ T cell development after birth. Nicotine 60-68 CD4 antigen Mus musculus 144-147