PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18646640-11	2008	Nicotine increased tPA protein levels and promoted the release of tPA into the extracellular space in the NAc.	Nicotine	0-8	plasminogen activator, tissue	Mus musculus	19-22	
18646640-0	2008	[Role of tissue plasminogen activator in the rewarding effect of nicotine].	Nicotine	65-73	plasminogen activator, tissue	Mus musculus	9-37	
18646640-8	2008	Here we show that the tPA-plasmin system regulates nicotine-induced reward and dopamine release.	Nicotine	51-59	plasminogen activator, tissue	Mus musculus	22-25	
18646640-10	2008	Nicotine-induced dopamine release was markedly diminished in tPA-deficient (tPA-/-) mice, and the defect of dopamine release in tPA-/- mice was restored by microinjection of either exogenous tPA or plasmin into the NAc.	Nicotine	0-8	plasminogen activator, tissue	Mus musculus	61-64	
18646640-10	2008	Nicotine-induced dopamine release was markedly diminished in tPA-deficient (tPA-/-) mice, and the defect of dopamine release in tPA-/- mice was restored by microinjection of either exogenous tPA or plasmin into the NAc.	Nicotine	0-8	plasminogen activator, tissue	Mus musculus	76-83	
18646640-10	2008	Nicotine-induced dopamine release was markedly diminished in tPA-deficient (tPA-/-) mice, and the defect of dopamine release in tPA-/- mice was restored by microinjection of either exogenous tPA or plasmin into the NAc.	Nicotine	0-8	plasminogen activator, tissue	Mus musculus	76-79	
18646640-10	2008	Nicotine-induced dopamine release was markedly diminished in tPA-deficient (tPA-/-) mice, and the defect of dopamine release in tPA-/- mice was restored by microinjection of either exogenous tPA or plasmin into the NAc.	Nicotine	0-8	plasminogen activator, tissue	Mus musculus	76-79	
19098386-0	2008	Basic and translational research on proteinase-activated receptors: regulation of nicotine reward by the tissue plasminogen activator (tPA) - plasmin system via proteinase-activated receptor 1.	Nicotine	82-90	plasminogen activator, tissue	Mus musculus	135-138	
19098386-3	2008	We show that the tissue plasminogen activator (tPA) - plasmin system regulates nicotine-induced reward and dopamine release in the nucleus accumbens (NAc) by activating proteinase-activated receptor 1 (PAR(1)).	Nicotine	79-87	plasminogen activator, tissue	Mus musculus	47-50	
19098386-4	2008	Nicotine-induced conditioned place preference and dopamine release in the NAc are diminished in tPA knockout (tPA-/-) mice.	Nicotine	0-8	plasminogen activator, tissue	Mus musculus	96-99	
19098386-4	2008	Nicotine-induced conditioned place preference and dopamine release in the NAc are diminished in tPA knockout (tPA-/-) mice.	Nicotine	0-8	plasminogen activator, tissue	Mus musculus	110-117	
19098386-5	2008	The defect of nicotine-induced dopamine release in tPA-/- mice is reversed by microinjection of either exogenous tPA or plasmin into the NAc.	Nicotine	14-22	plasminogen activator, tissue	Mus musculus	51-57	
19098386-5	2008	The defect of nicotine-induced dopamine release in tPA-/- mice is reversed by microinjection of either exogenous tPA or plasmin into the NAc.	Nicotine	14-22	plasminogen activator, tissue	Mus musculus	51-54	
19098386-6	2008	Acute nicotine treatment increases tPA protein levels and promoted the release of tPA into the extracellular space.	Nicotine	6-14	plasminogen activator, tissue	Mus musculus	35-38	
19098386-6	2008	Acute nicotine treatment increases tPA protein levels and promoted the release of tPA into the extracellular space.	Nicotine	6-14	plasminogen activator, tissue	Mus musculus	82-85	
19098386-9	2008	These findings suggest that targeting the tPA-plasmin-PAR(1) system would provide new therapeutic approaches for the treatment of nicotine dependence.	Nicotine	130-138	plasminogen activator, tissue	Mus musculus	42-45	
18646640-11	2008	Nicotine increased tPA protein levels and promoted the release of tPA into the extracellular space in the NAc.	Nicotine	0-8	plasminogen activator, tissue	Mus musculus	66-69	
18646640-14	2008	Our findings suggest that targeting the tPA-plasmin-PAR1 system would provide new therapeutic approaches to the treatment of nicotine dependence.	Nicotine	125-133	plasminogen activator, tissue	Mus musculus	40-43	
17122062-0	2006	The rewards of nicotine: regulation by tissue plasminogen activator-plasmin system through protease activated receptor-1.	Nicotine	15-23	plasminogen activator, tissue	Mus musculus	39-67	
18411702-8	2008	Finally, we show that the tPA-plasmin system regulates nicotine-induced reward and dopamine release by activating protease activated receptor-1 (PAR1).	Nicotine	55-63	plasminogen activator, tissue	Mus musculus	26-29	
17122062-7	2006	Nicotine increased tPA protein levels and promoted the release of tPA into the extracellular space in the NAc.	Nicotine	0-8	plasminogen activator, tissue	Mus musculus	19-22	
17122062-7	2006	Nicotine increased tPA protein levels and promoted the release of tPA into the extracellular space in the NAc.	Nicotine	0-8	plasminogen activator, tissue	Mus musculus	66-69	
17122062-10	2006	Targeting the tPA-plasmin-PAR1 system would provide new therapeutic approaches to the treatment of nicotine dependence.	Nicotine	99-107	plasminogen activator, tissue	Mus musculus	14-17	
18411702-9	2008	Nicotine-induced dopamine release is markedly diminished in tPA-/- mice.	Nicotine	0-8	plasminogen activator, tissue	Mus musculus	60-63	
17122062-4	2006	Here we show that the tissue plasminogen activator (tPA)-plasmin system regulates nicotine-induced reward and dopamine release by activating protease activated receptor-1 (PAR1).	Nicotine	82-90	plasminogen activator, tissue	Mus musculus	22-50	
17122062-4	2006	Here we show that the tissue plasminogen activator (tPA)-plasmin system regulates nicotine-induced reward and dopamine release by activating protease activated receptor-1 (PAR1).	Nicotine	82-90	plasminogen activator, tissue	Mus musculus	52-55	
17122062-5	2006	In vivo microdialysis revealed that microinjection of either tPA or plasmin into the nucleus accumbens (NAc) significantly potentiated whereas plasminogen activator inhibitor-1 reduced the nicotine-induced dopamine release in the NAc in a dose-dependent manner.	Nicotine	189-197	plasminogen activator, tissue	Mus musculus	61-64	
17122062-6	2006	Nicotine-induced dopamine release was markedly diminished in tPA-deficient (tPA-/-) mice, and the defect of dopamine release in tPA-/- mice was restored by microinjection of either exogenous tPA or plasmin into the NAc.	Nicotine	0-8	plasminogen activator, tissue	Mus musculus	61-64	
17122062-6	2006	Nicotine-induced dopamine release was markedly diminished in tPA-deficient (tPA-/-) mice, and the defect of dopamine release in tPA-/- mice was restored by microinjection of either exogenous tPA or plasmin into the NAc.	Nicotine	0-8	plasminogen activator, tissue	Mus musculus	76-83	
17122062-6	2006	Nicotine-induced dopamine release was markedly diminished in tPA-deficient (tPA-/-) mice, and the defect of dopamine release in tPA-/- mice was restored by microinjection of either exogenous tPA or plasmin into the NAc.	Nicotine	0-8	plasminogen activator, tissue	Mus musculus	76-79	
17122062-6	2006	Nicotine-induced dopamine release was markedly diminished in tPA-deficient (tPA-/-) mice, and the defect of dopamine release in tPA-/- mice was restored by microinjection of either exogenous tPA or plasmin into the NAc.	Nicotine	0-8	plasminogen activator, tissue	Mus musculus	76-79