PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28960194-5 2017 Animals exposed to nicotine showed significantly heightened serum cotinine and IL-6 levels corresponding to those of regular European smokers. Nicotine 19-27 interleukin 6 Rattus norvegicus 79-83 31403667-8 2020 By real-time PCR test, the mRNA of alpha 4 nAChR and beta 2 nAChR in rats given nicotine increased significantly compared with ischemic rats and decreased TNF-alpha, IL-1beta, and IL-6 mRNA (all ps < .05). Nicotine 80-88 interleukin 6 Rattus norvegicus 180-184 33002592-8 2020 Higher doses of nicotine were associated with higher glucose, HbA1c, leptin, IL-6, MDA and lipids levels, while, insulin, adiponectin, G6PDH, hexokinase and HDL levels were lower. Nicotine 16-24 interleukin 6 Rattus norvegicus 77-81 26259694-3 2015 We found that acute nicotine injection markedly attenuated LPS-elicited cognitive deficits and suppressed the strong LPS-induced release of IL-1beta, IL-6, and TNF-alpha into serum and the dorsal hippocampus at 4 and 24h after LPS injection. Nicotine 20-28 interleukin 6 Rattus norvegicus 150-154 26684861-6 2016 RESULTS: Pretreatment with nicotine strongly alleviated severity of SAP-associated lung injury through attenuating serum amylase, lipase, and interleukin 6 levels; pancreas and lung pathological injury; lung myeloperoxidase activity; lung tumor necrosis factor-alpha; and high-mobility group box 1 expression. Nicotine 27-35 interleukin 6 Rattus norvegicus 68-155 27832994-5 2016 Supplementation with folic acid and vitamin B12 suppressed the nicotine induced changes in HbA1c, insulin, TNF-alpha, IL-6, generation of reactive oxygen species, and attenuated the changes in markers of oxidative stress. Nicotine 63-71 interleukin 6 Rattus norvegicus 118-122 26992678-7 2016 RESULTS: Nicotine suppresses LPS-stimulated placental proinflammatory cytokines (IL-1, IL-2, IL-6, TNF-alpha, IFN-gamma) production except IL-17 in vitro, and reduces leucocytes infiltration in the placental chorionic plate caused by LPS in vivo. Nicotine 9-17 interleukin 6 Rattus norvegicus 93-97 25973643-7 2016 Moreover, folic acid in combination with vitamin B12 also attenuated the nicotine-induced changes in markers of oxidative stress (17-88% recovery), TNF-alpha (40-99% recovery), and IL-6 level (47-65% recovery), CRP level (59-73% recovery), expression of NF-kappaB and caspase-3, and apoptosis in pancreatic islet cells. Nicotine 73-81 interleukin 6 Rattus norvegicus 181-185 25671045-10 2014 Nicotine treatment led to a decrease of the effect of the burn trauma with significantly lower concentrations of tumor necrosis factor alpha, interleukin 1 beta, and interleukin 6 compared to the trauma group. Nicotine 0-8 interleukin 6 Rattus norvegicus 166-179 25242867-6 2014 Mean +- SD serum level of IL-6 and TNF-alpha among all groups exposed to nicotine, except for 2 mg/kg nicotine injected group, was increased significantly (P < 0.0001). Nicotine 73-81 interleukin 6 Rattus norvegicus 26-30 24769008-6 2014 Nicotine treatment significantly reduces LPS-induced TNF-alpha and IL-6 concentrations (P < .001) but does not change (P > .05) IL-10 levels. Nicotine 0-8 interleukin 6 Rattus norvegicus 67-71 19673871-11 2009 I/R treatment increased mRNA levels of COX-2, IL-1beta, IL-6 and iNOS, which were further augmented by nicotine in a dose-dependent manner. Nicotine 103-111 interleukin 6 Rattus norvegicus 56-60 22904093-9 2012 Nicotine and Ang II enhanced this TLR-mediated IL-6 response in prehypertensive SHR splenocytes. Nicotine 0-8 interleukin 6 Rattus norvegicus 47-51 22904093-10 2012 In contrast, nicotine suppressed the TLR-mediated IL-6 response in WKY rats, whereas Ang II had no effect. Nicotine 13-21 interleukin 6 Rattus norvegicus 50-54 22904093-11 2012 In vivo, nicotine enhanced plasma levels of TLR7/8-mediated IL-6 and IL-1beta responses in prehypertensive SHRs but suppressed these responses in WKY rats. Nicotine 9-17 interleukin 6 Rattus norvegicus 60-64 20805763-10 2011 Cell experiments also showed that increases of TNF-alpha and IL-6 after LPS stimulation could be significantly inhibited by carbachol or nicotine, whereas IL-10 was not apparently altered. Nicotine 137-145 interleukin 6 Rattus norvegicus 61-65 22371792-9 2010 RESULTS: Nicotine increased serum bone-resorbing cytokines (interleukin-1 and interleukin-6) and the bone resorption marker pyridinoline (PYD) while reducing the bone formation marker osteocalcin after 2 months of nicotine treatment. Nicotine 9-17 interleukin 6 Rattus norvegicus 78-91 17342286-7 2007 RESULTS: Palm tocotrienol mixture was able to prevent the increment of IL-1 and IL- 6 due to nicotine treatment. Nicotine 93-101 interleukin 6 Rattus norvegicus 80-85 17525204-12 2007 However, nicotine decreased the endotoxin-induced elevation of interleukin (IL)-6, IL-1beta, tumor necrosis factor (TNF)-alpha, cytokine-induced neutrophil chemoattractant (CINC)-1, and monocyte chemotactic protein (MCP)-1, but did not affect IL-10 in the serum and aqueous humor. Nicotine 9-17 interleukin 6 Rattus norvegicus 63-81 17342286-11 2007 CONCLUSION: Palm tocotrienol mixture was better than alpha-tocopherol in reversing the effects of nicotine on IL-1 and IL-6. Nicotine 98-106 interleukin 6 Rattus norvegicus 119-123 17323178-10 2007 Biochemical analysis revealed that nicotine treatment for 4 months significantly increased the serum IL-1, IL-6, and cotinine levels as compared to pretreatment levels. Nicotine 35-43 interleukin 6 Rattus norvegicus 107-111 12725137-7 2003 RESULTS: Nicotine decreased IL-10 and increased IL-6 levels in small bowel mucosa (from 3.5 +/- 0.5 to 0.4 +/- 0.1 pg/ml and from 1.9 +/- 0.4 to 13.6 +/- 0.4 pg/ml respectively; P < 0.05). Nicotine 9-17 interleukin 6 Rattus norvegicus 48-52 12725137-9 2003 Rats treated with nicotine had lower IL-6 and IL-2 blood levels compared to control rats. Nicotine 18-26 interleukin 6 Rattus norvegicus 37-41