PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16450214-1	2006	PURPOSE: The aim of the study is to identify specific protein kinase C (PKC) isoforms involvement in K(+) transport mediated at altered blood-brain barrier (BBB) response to stroke conditions with prior nicotine exposure, which provides ways to intervene pharmacologically in PKC-mediated molecular pathways that could lead to effective treatment for smoking stroke patients.	Nicotine	203-211	protein kinase C alpha	Homo sapiens	72-75	
16450214-1	2006	PURPOSE: The aim of the study is to identify specific protein kinase C (PKC) isoforms involvement in K(+) transport mediated at altered blood-brain barrier (BBB) response to stroke conditions with prior nicotine exposure, which provides ways to intervene pharmacologically in PKC-mediated molecular pathways that could lead to effective treatment for smoking stroke patients.	Nicotine	203-211	protein kinase C alpha	Homo sapiens	276-279	
16450214-2	2006	METHODS: Changes in PKC isoform levels were studied in the cytosolic and membrane fractions of bovine brain microvessel endothelial cells subjected to stroke conditions as well as nicotine/cotinine exposure.	Nicotine	180-188	protein kinase C alpha	Homo sapiens	20-23	
16450214-4	2006	RESULTS: Membrane-bound PKCalpha, PKCbetaI, and PKCepsilon levels were increased after 6 h hypoxia/aglycemia, and this was attenuated by 24-h nicotine/cotinine exposure.	Nicotine	142-150	protein kinase C alpha	Homo sapiens	24-32	
12421819-6	2003	Nicotine induces activation of PKC alpha and the MAPKs ERK1 and ERK2, which are physiological Bcl2 kinases.	Nicotine	0-8	protein kinase C alpha	Homo sapiens	31-40	
16846598-0	2006	Nicotine-induced upregulation of human neuronal nicotinic alpha7-receptors is potentiated by modulation of cAMP and PKC in SH-EP1-halpha7 cells.	Nicotine	0-8	protein kinase C alpha	Homo sapiens	116-119	
16846598-5	2006	Down-regulation of protein kinase C (PKC) with a phorbol ester abolishes the nicotine-induced upregulation of alpha7-nicotinic receptors.	Nicotine	77-85	protein kinase C alpha	Homo sapiens	37-40	
16846598-6	2006	Furthermore, overexpression of PKCalpha in SH-EP1-halpha7 cells results in potentiation of nicotine-evoked upregulation indicating that PKC has a role in regulation of alpha7-nicotinic receptor number.	Nicotine	91-99	protein kinase C alpha	Homo sapiens	31-39	
16846598-6	2006	Furthermore, overexpression of PKCalpha in SH-EP1-halpha7 cells results in potentiation of nicotine-evoked upregulation indicating that PKC has a role in regulation of alpha7-nicotinic receptor number.	Nicotine	91-99	protein kinase C alpha	Homo sapiens	31-34	
16846598-8	2006	Taken together this study provides evidence that nicotine induces accumulation of cAMP and that the upregulation mechanisms of alpha7-nicotinic receptors are potentiated both by cAMP and PKC.	Nicotine	49-57	protein kinase C alpha	Homo sapiens	187-190