PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16530419-3	2006	Immunoblot analysis showed that chronic nicotine treatment (1 mg/kg, 2 times/day) normalized the stress-induced decrease in the basal levels of BDNF, CaMKII (total and phosphorylated; P-CaMKII), and calmodulin.	Nicotine	40-48	calmodulin 1	Rattus norvegicus	199-209	
21596105-10	2011	However, CaMKIIalpha was significantly upregulated with nicotine treatment while CaM showed downregulation at P14.	Nicotine	56-64	calmodulin 1	Rattus norvegicus	9-12	
21507900-6	2011	Signaling studies revealed that Ca(2+)(cyt) elevations evoked by nicotine and concomitant depolarizing treatments served to activate a survival pathway involving the calcium effector protein calmodulin and phosphatidylinositol 3-kinase.	Nicotine	65-73	calmodulin 1	Rattus norvegicus	191-201	
21091651-4	2011	EXPERIMENTAL APPROACH: Depressor responses to nicotine microinjected into the NTS of Wistar-Kyoto rats were elicited in the absence and presence of an antagonist of alpha7 nAChR, the calcium chelator ethylene glycol tetraacetic acid, a calmodulin-specific inhibitor, nitric oxide (NO) synthase (NOS) inhibitor, endothelial NOS (eNOS)-selective inhibitor or neuronal NOS (nNOS)-specific inhibitor.	Nicotine	46-54	calmodulin 1	Rattus norvegicus	236-246	
21091651-6	2011	This depressor effect of nicotine was attenuated after pretreatment with a nAChR antagonist or blockers of the calmodulin-eNOS pathway.	Nicotine	25-33	calmodulin 1	Rattus norvegicus	111-121	
21091651-8	2011	Calmodulin was found to bind eNOS after nicotine injection into NTS.	Nicotine	40-48	calmodulin 1	Rattus norvegicus	0-10	
16307449-5	2006	Stress also facilitated the induction of LTD. Nicotine treatment of stressed rats prevented stress-induced enhancement and facilitation of LTD. For chronically stressed rats, we previously reported marked decreases in the basal levels of brain-derived neurotrophic factor (BDNF), CaMKII, P-CaMKII, and calmodulin as well as a significant increase in calcineurin basal levels.	Nicotine	46-54	calmodulin 1	Rattus norvegicus	302-312	
11701752-8	2001	A calmodulin antagonist, a CaM kinase inhibitor, a MAP kinase kinase inhibitor inhibited nicotine-induced ERK and CREB phosphorylation.	Nicotine	89-97	calmodulin 1	Rattus norvegicus	2-12	
12472891-6	2002	L-type voltage-sensitive calcium channel (VSCC) antagonists, calmodulin antagonist, and Ca2+/calmudulin-dependent protein kinase (CaM kinase) inhibitor prevented the nicotine-induced Akt phosphorylation.	Nicotine	166-174	calmodulin 1	Rattus norvegicus	61-71