PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31150435-4	2019	Endogenous Lynx1 controls the nicotine-induced up-regulation of the expression of alpha7 type nAChRs in lung adenocarcinoma A549 cells as well as the cell growth.	Nicotine	30-38	Ly6/neurotoxin 1	Homo sapiens	11-16	
22923641-6	2012	Treatment of primary cultures of BEC with nicotine increased levels of nAChR subunits and that increase was potentiated by lynx1 knockdown.	Nicotine	42-50	Ly6/neurotoxin 1	Homo sapiens	123-128	
22923641-7	2012	Lynx1 knockdown also potentiated the nicotine-induced increase in GABA(A) receptors (GABA(A)R) and MUC5AC mRNA expression, and that effect was blocked by alpha7 antagonists and alpha7 knockdown.	Nicotine	37-45	Ly6/neurotoxin 1	Homo sapiens	0-5	
22923641-9	2012	Consistent with this, inhibition of Src signaling blocked the ability of the lynx1 knockdown to increase basal and nicotine-stimulated GABA(A)R and mucin mRNA expression.	Nicotine	115-123	Ly6/neurotoxin 1	Homo sapiens	77-82	
28100642-7	2017	Lynx1 is expressed in the habenulopeduncular tract, where alpha3beta4*-alpha5*-nAChR subtypes are critical contributors to the balance between nicotine aversion and reward.	Nicotine	143-151	Ly6/neurotoxin 1	Homo sapiens	0-5	
26025503-6	2015	In normal lung lynx1 serves to limit the ability of chronic nicotine exposure to increase levels of nicotinic receptors and also serves to limit the ability of nicotine to upregulate levels of GABAA receptors in lung.	Nicotine	60-68	Ly6/neurotoxin 1	Homo sapiens	15-20	
26025503-6	2015	In normal lung lynx1 serves to limit the ability of chronic nicotine exposure to increase levels of nicotinic receptors and also serves to limit the ability of nicotine to upregulate levels of GABAA receptors in lung.	Nicotine	160-168	Ly6/neurotoxin 1	Homo sapiens	15-20	
26025503-7	2015	In turn this allows lynx1 to limit the ability of nicotine to upregulate levels of mucin which is mediated by GABAergic signaling.	Nicotine	50-58	Ly6/neurotoxin 1	Homo sapiens	20-25	
16575903-6	2006	Recombinant SLURP-2 (rSLURP-2) competed with nicotinic radioligands for binding to keratinocytes, showing a higher affinity to the [3H]epibatidine- than [3H]nicotine-labeled sites.	Nicotine	157-165	Ly6/neurotoxin 1	Homo sapiens	12-19