PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29172281-0 2017 SNP rs16969968 as a Strong Predictor of Nicotine Dependence and Lung Cancer Risk in a North Indian Population Background: The 15q24-25 loci contain genes (CHRNA5 and CHRNA3) encoding nicotinic acetylcholine receptorsubunits. Nicotine 40-48 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 155-161 26751916-1 2016 Polymorphisms in the nicotinic acetylcholine receptor gene (CHRNA5/CHRNA3 locus) have been associated with several smoking related traits such as nicotine dependence, cigarette consumption, smoking cessation, lung cancer, and COPD. Nicotine 146-154 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 60-66 27698409-0 2016 Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele. Nicotine 10-18 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 71-77 26239294-0 2016 Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans. Nicotine 83-91 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 50-56 26771213-9 2016 Our top result was rs16969968 (P = 1.7 x 10(-14)) in CHRNA5, a locus previously associated with COPD susceptibility and nicotine dependence. Nicotine 120-128 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 53-59 27127891-0 2016 Association Between CHRNA3 and CHRNA5 Nicotine Receptor Subunit Gene Variants and Nicotine Dependence in an Isolated Populationof Kashubians in Poland. Nicotine 38-46 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 31-37 27127891-1 2016 BACKGROUND Genome-wide and allelic association studies have shown the contribution of CHRNA5-A3-B4 nicotinic receptor subunit gene cluster within chromosome 15 to nicotine dependence (ND). Nicotine 163-171 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 86-92 26239294-1 2016 The common nonsynonymous variant rs16969968 in the alpha5 nicotinic receptor subunit gene (CHRNA5) is the strongest genetic risk factor for nicotine dependence in European Americans and contributes to risk in African Americans. Nicotine 140-148 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 91-97 26239294-8 2016 Our results indicate that common, low frequency and rare CHRNA5 coding variants are independently associated with nicotine dependence risk. Nicotine 114-122 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 57-63 25948103-0 2015 A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans. Nicotine 64-72 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 2-8 26997181-0 2016 CHRNA5/A3/B4 Variant rs3743078 and Nicotine-Related Phenotypes: Indirect Effects Through Nicotine Craving. Nicotine 35-43 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 0-6 26997181-0 2016 CHRNA5/A3/B4 Variant rs3743078 and Nicotine-Related Phenotypes: Indirect Effects Through Nicotine Craving. Nicotine 89-97 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 0-6 25948103-3 2015 We evaluated the effects of a candidate causal variant in CHRNA5, rs16969968, on the acute response to nicotine in European American (EA) and African American (AA) smokers (n=192; 50% AA; 73% male). Nicotine 103-111 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 58-64 26220977-0 2015 A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence. Nicotine 111-119 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 65-71 26220977-1 2015 Nicotine dependence is influenced by chromosome 15q25.1 single nucleotide polymorphisms (SNPs), including the missense SNP rs16969968 that alters function of the alpha5 nicotinic acetylcholine receptor (CHRNA5) and noncoding SNPs that regulate CHRNA5 mRNA expression. Nicotine 0-8 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 203-209 26220977-1 2015 Nicotine dependence is influenced by chromosome 15q25.1 single nucleotide polymorphisms (SNPs), including the missense SNP rs16969968 that alters function of the alpha5 nicotinic acetylcholine receptor (CHRNA5) and noncoding SNPs that regulate CHRNA5 mRNA expression. Nicotine 0-8 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 244-250 26220977-5 2015 Of the eight cis-meQTL SNPs, only the intronic CHRNB4 SNP rs11636753 was associated with CHRNA5 methylation independently of the known SNP effects in prefrontal cortex, and it was the most significantly associated SNP with nicotine dependence across five independent cohorts (total N = 7858 European ancestry and 3238 AA participants): P = 6.7 x 10(-4), odds ratio (OR) [95% confidence interval (CI)] = 1.11 (1.05-1.18). Nicotine 223-231 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 89-95 26220977-8 2015 Our findings identify a novel regulatory SNP association with nicotine dependence and connect, for the first time, previously observed differences in CHRNA5 mRNA expression and nicotine dependence risk to underlying DNA methylation differences. Nicotine 62-70 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 150-156 27350810-3 2015 We previously identified common SNPs in a distant regulatory element (DRE) that increase CHRNA5 mRNA expression in the human prefrontal cortex (PFC) and confer risk for nicotine dependence. Nicotine 169-177 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 89-95 26142345-2 2015 This study tests whether the coding variant rs16969968 in the CHRNA5 nicotinic receptor gene predicts the effects of combination nicotine replacement therapy (cNRT) and varenicline on treatment outcomes. Nicotine 129-137 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 62-68 25233467-6 2014 Results show that nicotine dependence is a mediator of the association between lung adenocarcinoma and gene variations in the regions of CHRNA5/A3/B4 and accounts for approximately 15% of this relationship. Nicotine 18-26 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 137-143 25297392-1 2014 Genome-wide association and large cohort studies have consistently linked several single nucleotide polymorphisms (SNPs) located in the CHRNA5/A3/B4 gene cluster to smoking behaviors and nicotine dependence. Nicotine 187-195 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 136-142 25297392-6 2014 8 SNPs were selected based on findings from recent studies on smoking and nicotine dependence, all located in the nicotinic acetylcholine receptor subunits CHRNA5/A3/B4 gene cluster. Nicotine 74-82 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 156-162 25384568-0 2014 Hippocampal changes produced by overexpression of the human CHRNA5/A3/B4 gene cluster may underlie cognitive deficits rescued by nicotine in transgenic mice. Nicotine 129-137 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 60-66 25233467-10 2014 Our findings suggest that nicotine dependence plays an important role between genetic variants in the CHRNA5/A3/B4 region, especially CHRNA3, and lung adenocarcinoma. Nicotine 26-34 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 102-108 26228411-8 2015 This approach, combined with an optimized genetic selection strategy (Vrieze et al., 2012), revealed genetic variants involved in stress regulation (FKBP5, SERT x OPMR), social bonding (OXTR), and nicotine responsivity (CHRNA5) in predicting comorbid status. Nicotine 197-205 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 220-226 25745024-11 2015 By utilizing additional information (i.e., between-family information), family-U confirmed a previous association of CHRNA5 with nicotine dependence. Nicotine 129-137 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 117-123 25950378-1 2015 OBJECTIVE: To assess if the allelic variations of rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene cluster are associated with smoking cessation after nicotine replacement therapy (NRT). Nicotine 156-164 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 78-84 24682045-6 2014 CONCLUSION: We conclude that, in African-Americans, variants (common or rare) in genes other than CHRNA5 most likely contribute toward the nicotine-dependent phenotype, either independently or in combination with variants in CHRNA5. Nicotine 139-147 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 225-231 24934182-0 2014 CHRNA5 variants moderate the effect of nicotine deprivation on a neural index of cognitive control. Nicotine 39-47 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 0-6 24934182-3 2014 Minor allele carriers at rs16969968 in the nicotinic acetylcholine receptor alpha5 subunit gene (CHRNA5) have been shown to exhibit both reduced cognitive control and greater nicotine dependence. Nicotine 175-183 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 97-103 24934182-6 2014 We tested the hypothesis that individuals possessing at least one minor allele at rs16969968 in CHRNA5 would show greater nicotine deprivation-induced reductions in P3b and P3a amplitude. Nicotine 122-130 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 96-102 24033696-10 2014 The effect of nicotine replacement on continuous abstinence is moderated by the combined genetic risks from CYP2A6 and CHRNA5 (Wald = 7.44, d.f. Nicotine 14-22 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 119-125 24804708-4 2014 We previously undertook pooled sequencing of the coding regions and flanking sequence of the CHRNA5, CHRNA3, CHRNB4, CHRNA6 and CHRNB3 genes and found that rare missense variants at conserved residues in CHRNB4 are associated with reduced risk of nicotine dependence among African Americans. Nicotine 247-255 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 93-99 25214750-5 2013 The genetic variants in the CHRNA5-CHRNA3-CHRNB4 region that predict nicotine dependence also predict a later age of smoking cessation in a community-based sample. Nicotine 69-77 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 28-34 24227714-1 2013 The Chrna5 gene encodes the alpha5 nicotinic acetylcholine receptor subunit, an "accessory" subunit of pentameric nicotinic receptors, that has been shown to play a role in nicotine-related behaviors in rodents and is genetically linked to smoking behavior in humans. Nicotine 173-181 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 4-10 23692359-0 2013 CHRNA5-A3-B4 genetic variants alter nicotine intake and interact with tobacco use to influence body weight in Alaska Native tobacco users. Nicotine 36-44 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 0-6 23692359-3 2013 We investigated CHRNA5-A3-B4 haplotype structure and its association with nicotine intake and obesity in Alaska Native people. Nicotine 74-82 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 16-22 23692359-7 2013 In 290 Alaska Native tobacco users the "G" allele of rs578776, which tagged a 30 kb haplotype in CHRNA5-A3-B4, was prevalent (16%) and associated significantly with nicotine intake (20% higher plasma cotinine, P < 0.001, 16% higher TNE, P = 0.076), while rs16969968 was not associated with nicotine intake. Nicotine 165-173 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 97-103 23692359-7 2013 In 290 Alaska Native tobacco users the "G" allele of rs578776, which tagged a 30 kb haplotype in CHRNA5-A3-B4, was prevalent (16%) and associated significantly with nicotine intake (20% higher plasma cotinine, P < 0.001, 16% higher TNE, P = 0.076), while rs16969968 was not associated with nicotine intake. Nicotine 293-301 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 97-103 23692359-10 2013 CONCLUSIONS: Genetic variants in CHRNA5-A3-B4 alter nicotine intake and body mass index in a population of Alaska Native people, who have a distinct haplotype structure, smoking behaviors and prevalence of obesity. Nicotine 52-60 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 33-39 23458267-1 2013 BACKGROUND: Common variants in the CHRNA5-A3-B4 gene cluster have been shown to be associated with nicotine dependence and alcohol use disorders (AUDs) and related traits, including the level of response (LR) to alcohol. Nicotine 99-107 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 35-41 24062692-4 2013 Recently, variants in the nAChR genes CHRNA3, CHRNA5, and CHRNB4 have been implicated in nicotine dependence and lung cancer susceptibility. Nicotine 89-97 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 46-52 23875064-1 2013 The CHRNA5-CHRNA3-CHRNB4 gene cluster on chromosome 15q25.1 encoding the cholinergic nicotinic receptor subunits is robustly associated with smoking behavior and nicotine dependence. Nicotine 162-170 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 4-10 22820273-2 2012 The N398 variant of CHRNA5 is linked to increased risk for nicotine dependence. Nicotine 59-67 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 20-26 22884254-0 2013 Association of nicotine dependence susceptibility gene, CHRNA5, with Parkinson"s disease age at onset: gene and smoking status interaction. Nicotine 15-23 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 56-62 23308091-0 2013 A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia. Nicotine 113-121 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 81-87 22042234-3 2012 Genetic variation in the CHRNA5/CHRNA3/CHRNB4 gene cluster has been associated with early substance experimentation, nicotine dependence, and other drug behaviors. Nicotine 117-125 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 25-31 22101982-2 2012 Recent genetic studies have highlighted the importance of variants of the CHRNA5/A3/B4 genomic cluster in human nicotine dependence. Nicotine 112-120 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 74-80 22640768-10 2012 A few well-validated, specific predictors such as OPRM1, ADH1B, ALDH2, CHRNA5, and CYP26 have been identified and can provide some specific guidance, for example, to understand alcohol-related flushing and upper GI cancer risk (ADH1B and AKLDH2), variation in nicotine metabolism (CYP26), and, potentially, naltrexone treatment response (OPRM1). Nicotine 260-268 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 71-77 21968931-0 2012 The CHRNA5-A3-B4 gene cluster in nicotine addiction. Nicotine 33-41 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 4-10 22241830-0 2012 Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits. Nicotine 107-115 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 48-54 22380605-1 2012 Gene association studies in humans have linked the alpha5 subunit gene CHRNA5 to an increased risk for nicotine dependence. Nicotine 103-111 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 71-77 22102629-9 2012 CONCLUSIONS: CPD is an important simple measure that captures in part the genetic associations of CHRNA5 and nicotine dependence, even when other more comprehensive measures of smoking behaviors are examined. Nicotine 109-117 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 98-104 22012472-2 2012 Genome-wide association studies and rodent models have demonstrated that the alpha5 nicotinic acetylcholine receptor gene (CHRNA5) is important in regulating nicotine intake. Nicotine 158-166 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 123-129 22008662-7 2012 Rs16969968 in CHRNA5 was associated with the amount of nicotine used and in particular smoking 25 cigarettes or more per day. Nicotine 55-63 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 14-20 22008662-8 2012 Overall, the results confirm the involvement of the CHRNA5 gene in the amount of nicotine use and further suggest involvement of the BDNF gene in smoking behavior. Nicotine 81-89 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 52-58 21955800-0 2012 The polymorphism of the CHRNA5 gene and the strength of nicotine addiction in lung cancer and COPD patients. Nicotine 56-64 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 24-30 21955800-1 2012 A rare variant of chromosomal region 15q25.1, marked by rs16969968 (substitution 1354G>A in CHRNA5), was found to be associated with increased lung cancer and nicotine-dependence risk. Nicotine 162-170 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 95-101 21955800-2 2012 We attempted to confirm the relationship of the polymorphism of the CHRNA5 gene and nicotine-dependence strength measured by the Fagerstrom test with the serum cotinine level in lung cancer and chronic obstructive pulmonary disease (COPD) patients and healthy individuals. Nicotine 84-92 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 68-74 21955800-13 2012 We report for the first time the relationship between the polymorphism of the CHRNA5 gene and the strength of nicotine addiction measured by multiple factors including the Fagerstrom test score. Nicotine 110-118 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 78-84 22042774-3 2012 We undertook pooled sequencing of the coding regions and flanking sequence of the CHRNA5, CHRNA3, CHRNB4, CHRNA6 and CHRNB3 genes in African American and European American nicotine-dependent smokers and smokers without symptoms of dependence. Nicotine 172-180 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 82-88 21048701-3 2011 Recent human genetic association studies have implicated the gene cluster CHRNA3-CHRNA5-CHRNB4 encoding the alpha3, alpha5, and beta4 subunits of the nAChR in susceptibility to develop nicotine and alcohol dependence; however, their role in ethanol-mediated behaviors is unknown due to the lack of suitable and selective research tools. Nicotine 185-193 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 81-87 23061658-6 2012 Moreover variants on the gene cluster CHRNA3-CHRNB4-CHRNA5 are associated with nicotine addiction antismoking therapy and antismoking therapy side-effects. Nicotine 79-87 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 52-58 22071378-1 2011 INTRODUCTION: Variation in the CHRNA5-A3-B4 gene cluster is a promising candidate region for smoking behavior and has been linked to multiple smoking-related phenotypes (e.g., nicotine dependence) and diseases (e.g., lung cancer). Nicotine 176-184 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 31-37 21586512-0 2011 CHRNA5 as negative regulator of nicotine signaling in normal and cancer bronchial cells: effects on motility, migration and p63 expression. Nicotine 32-40 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 0-6 21418140-0 2011 A CHRNA5 allele related to nicotine addiction and schizophrenia. Nicotine 27-35 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 2-8 21268243-0 2011 Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy. Nicotine 96-104 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 62-68 21268243-7 2011 We focused on eight SNPs in the 15q24 region, which contains the genes for the nicotinic cholinergic receptor subunits CHRNA5, CHRNA3, and CHRNB4, and has previously been implicated in nicotine addiction and smoking cessation. Nicotine 185-193 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 119-125 21764527-0 2012 Association between CHRNA5 genetic variation at rs16969968 and brain reactivity to smoking images in nicotine dependent women. Nicotine 101-109 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 20-26 21764527-3 2012 Genome wide association studies revealed a relationship between development of nicotine dependence and a single-nucleotide polymorphism (SNP, rs16969968) of the nicotine acetylcholine receptor (nAChR) alpha-5 subunit gene (CHRNA5). Nicotine 79-87 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 223-229 22028403-1 2011 BACKGROUND: Genetic variants located at 15q25, including those in the cholinergic receptor nicotinic cluster (CHRNA5) have been implicated in both lung cancer risk and nicotine dependence in recent genome-wide association studies. Nicotine 168-176 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 110-116 21747048-5 2011 Cigarette consumption (P < .001) and nicotine dependence (P = .036) were the highest in the combined CYP2A6 normal metabolizers and CHRNA5-A3-B4 AA (tag single-nucleotide polymorphism rs1051730 G>A) risk group. Nicotine 40-48 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 135-141 21747048-7 2011 Variation in CYP2A6 and CHRNA5-A3-B4 was independently and additively associated with increased cigarette consumption, nicotine dependence, and lung cancer risk. Nicotine 119-127 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 24-30 20700147-1 2011 CHRNA5, encoding the nicotinic alpha5 subunit, is implicated in multiple disorders, including nicotine addiction and lung cancer. Nicotine 94-102 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 0-6 22046326-8 2011 Overall, our results suggest that genetic variants potentially involved in nicotine metabolization (mainly, CYP2A6 polymorphisms) are those showing the strongest association with smoking-related phenotypes, as opposed to genetic variants influencing the brain effects of nicotine, e.g., through nicotinic acetylcholine (CHRNA5), serotoninergic (HTR2A), opioid (OPRM1) or cannabinoid receptors (CNR1). Nicotine 75-83 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 320-326 21228559-2 2011 Recent genome-wide association studies (GWAS) have consistently linked several single nucleotide polymorphisms (SNPs) in the CHRNA3-CHRNA5-CHRNB4 cluster on chromosome 15.q25 to smoking behaviors and nicotine dependence. Nicotine 200-208 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 132-138 20840187-4 2010 Here we test the hypothesis that the nicotinic receptor genes CHRNA5 (rs16969968), CHRNA3 (rs578776), CHRNB3 (rs13277254) and CHRND (rs12466358) modify the risk for nicotine dependence associated with peer smoking. Nicotine 165-173 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 62-68 21858091-1 2011 Genome-wide association studies implicate variations in CHRNA5 and CHRNA3 as being associated with nicotine addiction (NA). Nicotine 99-107 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 56-62 20840187-11 2010 CONCLUSIONS: Peer smoking had a substantially lower effect on nicotine dependence among those with the high-risk AA genotype at the functional SNP rs16969968 (CHRNA5) than among those with lower-risk genotypes. Nicotine 62-70 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 159-165 20564069-1 2010 BACKGROUND: Recent genome-wide association studies of lung cancer have shown that the CHRNA5-A3 region on chromosome 15q24-25.1 is strongly associated with an increased risk of lung cancer and nicotine dependence, and is thought to be associated with chronic obstructive pulmonary disease as well. Nicotine 193-201 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 86-92 20685379-0 2010 The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer. Nicotine 77-85 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 37-43 20808433-1 2010 Multiple genome-wide and targeted association studies reveal a significant association of variants in the CHRNA5-CHRNA3-CHRNB4 (CHRNA5/A3/B4) gene cluster on chromosome 15 with nicotine dependence. Nicotine 177-185 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 106-112 20808433-1 2010 Multiple genome-wide and targeted association studies reveal a significant association of variants in the CHRNA5-CHRNA3-CHRNB4 (CHRNA5/A3/B4) gene cluster on chromosome 15 with nicotine dependence. Nicotine 177-185 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 128-134 20700436-1 2010 Recently, genetic association findings for nicotine dependence, smoking behavior, and smoking-related diseases converged to implicate the chromosome 15q25.1 region, which includes the CHRNA5-CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit genes. Nicotine 43-51 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 184-190 19859904-0 2010 Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans. Nicotine 91-99 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 52-58 19859904-1 2010 Several previous genome-wide and targeted association studies revealed that variants in the CHRNA5-CHRNA3-CHRNB4 (CHRNA5/A3/B4) gene cluster on chromosome 15 that encode the alpha5, alpha3, and beta4 subunits of the nicotinic acetylcholine receptors (nAChRs) are associated with nicotine dependence (ND) in European Americans (EAs) or others of European origin. Nicotine 279-287 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 92-98 19859904-1 2010 Several previous genome-wide and targeted association studies revealed that variants in the CHRNA5-CHRNA3-CHRNB4 (CHRNA5/A3/B4) gene cluster on chromosome 15 that encode the alpha5, alpha3, and beta4 subunits of the nicotinic acetylcholine receptors (nAChRs) are associated with nicotine dependence (ND) in European Americans (EAs) or others of European origin. Nicotine 279-287 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 114-120 19628476-1 2009 A cluster of three nicotinic acetylcholine receptor genes on chromosome 15 (CHRNA5/CHRNA3/CHRNB4) has been shown to be associated with nicotine dependence and smoking quantity. Nicotine 135-143 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 76-82 20124469-3 2010 Genome-wide association studies have implicated the nAChR gene cluster, CHRNA5/A3/B4, in nicotine addiction and lung cancer susceptibility. Nicotine 89-97 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 72-78 19628476-8 2009 Variation at CHRNA5/CHRNA3/CHRNB4 cluster influences nicotine level, measured as cotinine, more strongly than smoking quantity, measured by CPD, and appears thus to be involved in regulation of nicotine levels among smokers. Nicotine 53-61 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 13-19 19628476-8 2009 Variation at CHRNA5/CHRNA3/CHRNB4 cluster influences nicotine level, measured as cotinine, more strongly than smoking quantity, measured by CPD, and appears thus to be involved in regulation of nicotine levels among smokers. Nicotine 194-202 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 13-19 19443489-1 2009 Nicotine dependence risk and lung cancer risk are associated with variants in a region of chromosome 15 encompassing genes encoding the nicotinic receptor subunits CHRNA5, CHRNA3 and CHRNB4. Nicotine 0-8 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 164-170 19706762-0 2009 The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Nicotine 82-90 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 4-10 19706762-1 2009 Genetic association studies have shown the importance of variants in the CHRNA5-CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit gene cluster on chromosome 15q24-25.1 for the risk of nicotine dependence, smoking, and lung cancer in populations of European descent. Nicotine 187-195 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 73-79 19706762-6 2009 Other SNPs that have been shown to affect the mRNA levels of CHRNA5 in European-Americans are associated with nicotine dependence in African-Americans but not in European-Americans. Nicotine 110-118 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 61-67 19706762-9 2009 In summary, multiple variants in this gene cluster contribute to nicotine dependence risk, and some are also associated with functional effects on CHRNA5. Nicotine 65-73 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 147-153 20871796-1 2009 BACKGROUND: Several studies have found replicable associations between nicotine dependence and specific variants in the nicotinic receptor genes CHRNA5(rs16969968) and CHRNA3(rs3743078). Nicotine 71-79 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 145-151 19641473-10 2009 CONCLUSIONS: These findings suggest that SNPs in the CHRNA3 and CHRNA5 region contribute to lung cancer risk, and while variant alleles are less frequent in African Americans, risk in this group may be greater than in whites and less likely to reflect an indirect effect on lung cancer risk through nicotine dependence. Nicotine 299-307 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 64-70 19443489-0 2009 Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. Nicotine 9-17 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 109-115 19443489-3 2009 Using gene expression and disease association studies, we provide evidence that both nicotine-dependence risk and lung cancer risk are influenced by functional variation in CHRNA5. Nicotine 85-93 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 173-179 19443489-6 2009 When the non-risk allele occurs on the background of low mRNA expression of CHRNA5, the risk for nicotine dependence and lung cancer is significantly lower compared to those with the higher mRNA expression. Nicotine 97-105 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 76-82 19443489-8 2009 We conclude that there are at least two distinct mechanisms conferring risk for nicotine dependence and lung cancer: altered receptor function caused by a D398N amino acid variant in CHRNA5 (rs16969968) and variability in CHRNA5 mRNA expression. Nicotine 80-88 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 183-189 19443489-8 2009 We conclude that there are at least two distinct mechanisms conferring risk for nicotine dependence and lung cancer: altered receptor function caused by a D398N amino acid variant in CHRNA5 (rs16969968) and variability in CHRNA5 mRNA expression. Nicotine 80-88 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 222-228 34159514-2 2021 Genetic variants such as the CHRNA5 single nucleotide polymorphism (SNP) rs16969968, which leads to an aspartic acid to asparagine substitution at amino acid position 398 (D398N) in the alpha-5 nicotinic acetylcholine receptor subunit, can also confer risk for nicotine dependence and neurodevelopmental disorders in the absence of DNE. Nicotine 261-269 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 29-35 18519132-0 2008 A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence. Nicotine 18-26 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 41-47 18519132-1 2008 BACKGROUND: A nonsynonymous coding polymorphism, rs16969968, of the CHRNA5 gene that encodes the alpha-5 subunit of the nicotinic acetylcholine receptor (nAChR) has been found to be associated with nicotine dependence. Nicotine 198-206 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 68-74 18519132-4 2008 RESULTS: In the FSCD, there was a significant association between the CHRNA5 variant and cocaine dependence (odds ratio = .67 per allele, p = .0045, assuming an additive genetic model), but in the reverse direction compared with that previously observed for nicotine dependence. Nicotine 258-266 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 70-76 18519524-1 2008 OBJECTIVE: A recent study provisionally identified numerous genetic variants as risk factors for the transition from smoking to the development of nicotine dependence, including an amino acid change in the alpha5 nicotinic cholinergic receptor (CHRNA5). Nicotine 147-155 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 245-251 18618000-0 2008 A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. Nicotine 96-104 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 41-47 18618000-5 2008 In the 2,827 long-term smokers examined, common susceptibility and protective haplotypes at the CHRNA5-A3-B4 locus were associated with nicotine dependence severity (p = 2.0x10(-5); odds ratio = 1.82; 95% confidence interval 1.39-2.39) in subjects who began daily smoking at or before the age of 16, an exposure period that results in a more severe form of adult nicotine dependence. Nicotine 136-144 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 96-102 18618000-5 2008 In the 2,827 long-term smokers examined, common susceptibility and protective haplotypes at the CHRNA5-A3-B4 locus were associated with nicotine dependence severity (p = 2.0x10(-5); odds ratio = 1.82; 95% confidence interval 1.39-2.39) in subjects who began daily smoking at or before the age of 16, an exposure period that results in a more severe form of adult nicotine dependence. Nicotine 363-371 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 96-102 34803779-1 2021 The gene CHRNA5 is strongly associated with the level of nicotine consumption in humans and manipulation of the expression or function of Chrna5 similarly alters nicotine consumption in rodents. Nicotine 57-65 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 9-15 34803779-1 2021 The gene CHRNA5 is strongly associated with the level of nicotine consumption in humans and manipulation of the expression or function of Chrna5 similarly alters nicotine consumption in rodents. Nicotine 162-170 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 9-15 34803779-1 2021 The gene CHRNA5 is strongly associated with the level of nicotine consumption in humans and manipulation of the expression or function of Chrna5 similarly alters nicotine consumption in rodents. Nicotine 162-170 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 138-144 34803779-2 2021 In both humans and rodents, reduced or complete loss of function of Chrna5 leads to increased nicotine consumption. Nicotine 94-102 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 68-74 34803779-3 2021 However, the mechanism through which decreased function of Chrna5 increases nicotine intake is not well-understood. Nicotine 76-84 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 59-65 19436041-1 2009 INTRODUCTION: Previous research revealed significant associations between haplotypes in the CHRNA5-A3-B4 subunit cluster and scores on the Fagerstrom Test for Nicotine Dependence among individuals reporting daily smoking by age 17. Nicotine 159-167 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 92-98 19436041-8 2009 DISCUSSION: The CHRNA5-A3-B4 haplotypes are associated with a broad range of nicotine dependence phenotypes, but these associations are not consistently moderated by age at initial smoking. Nicotine 77-85 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 16-22 19064933-5 2008 Genetic association studies indicate that a genetic locus, which includes the CHRNA5-CHRNA3-CHRNB4 gene cluster, plays a role in nicotine consumption and dependence. Nicotine 129-137 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 78-84 18957677-0 2008 The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer. Nicotine 72-80 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 4-10 18783506-1 2008 AIMS: To extend the previously identified association between a single nucleotide polymorphism (SNP) in neuronal acetylcholine receptor subunit alpha-5 (CHRNA5) and nicotine dependence to current smoking and initial smoking-experience phenotypes. Nicotine 165-173 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 104-151 18783506-1 2008 AIMS: To extend the previously identified association between a single nucleotide polymorphism (SNP) in neuronal acetylcholine receptor subunit alpha-5 (CHRNA5) and nicotine dependence to current smoking and initial smoking-experience phenotypes. Nicotine 165-173 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 153-159 33801584-7 2021 In Mexican-Mestizo smokers, there are SNPs in genes that encode proteins responsible for the metabolism of nicotine associated with a lower risk of COPD; individuals with a high Caucasian component harboring a haplotype in the CHRNA5-CHRNA3 loci have a higher risk of suffering from COPD. Nicotine 107-115 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 227-233 34206324-1 2021 The gene cluster region, CHRNA3/CHRNA5/CHRNB4, encoding for nicotinic acetylcholine receptor (nAChR) subunits, contains several genetic variants linked to nicotine addiction and brain disorders. Nicotine 155-163 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 32-38 34206324-2 2021 The CHRNA5 single-nucleotide polymorphism (SNP) rs16969968 is strongly associated with nicotine dependence and lung diseases. Nicotine 87-95 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 4-10 32738310-0 2020 Genetic susceptibility to nicotine addiction: Advances and shortcomings in our understanding of the CHRNA5/A3/B4 gene cluster contribution. Nicotine 26-34 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 100-112 33879270-9 2021 Additional highlights from recent SUD GWAS include the robust confirmation of loci in alcohol metabolizing genes (e.g. ADH1B and ALDH2) affecting alcohol-related traits, and loci within the CHRNA5-CHRNA3-CHRNB4 gene cluster influencing nicotine-related traits. Nicotine 236-244 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 190-196 33539855-2 2021 In human populations, the single nucleotide polymorphism (SNP) D398N in the gene CHRNA5 has been associated with addiction to nicotine, opioids, cocaine, and alcohol. Nicotine 126-134 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 81-87 32152934-3 2020 In this sense, the CHRNA5 gene has been associated with nicotine (with genome-wide significance), alcohol and cocaine addictions. Nicotine 56-64 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 19-25 30293722-0 2018 A Human Polymorphism in CHRNA5 Is Linked to Relapse to Nicotine Seeking in Transgenic Rats. Nicotine 55-63 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 24-30 31547418-7 2019 CHRNA5 knockdown predominantly suppressed E2F activity and decreased the phosphorylation of the Rb protein; however, nicotine treatment dramatically promoted E2F activity and increased Rb phosphorylation, which was mitigated after CHRNA5 knockdown in OSCC cells. Nicotine 117-125 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 231-237 29993116-2 2018 Polymorphisms in CHRNA3, CHRNA5, and CHRNB4 receptors play a critical role in nicotine dependence, lung cancer (LC) risk, and chronic obstructive pulmonary disease (COPD). Nicotine 78-86 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 25-31 29993116-3 2018 This study characterized the CHRNA3 rs1051730 and CHRNA5 rs16969968 polymorphisms in a Mexican population and its association with nicotine dependence, LC, and COPD. Nicotine 131-139 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 50-56 32184221-2 2020 Human genome-wide association studies have linked polymorphisms in the CHRNA5-CHRNA3-CHRNB4 gene cluster, coding for the alpha5, alpha3 and beta4nAChR subunits, to nicotine addiction. Nicotine 164-172 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 71-77 32184221-11 2020 These data indicate that beta4 is a critical modulator of reward-related behaviors.SIGNIFICANCE STATEMENT: Human genetic studies have provided strong evidence for a relationship between variants in the CHRNA5-CHRNA3-CHRNB4 gene cluster and nicotine addiction. Nicotine 240-248 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 202-208 30366711-2 2019 The nicotinic acetylcholine receptor alpha5 subunit gene (CHRNA5) is reported to be associated with cognitive function in nicotine-dependent populations and SCZ in non-smoking SCZ patients. Nicotine 122-130 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 58-64 30543688-1 2018 Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) is an important susceptibility locus for nicotine addiction and lung cancer. Nicotine 89-97 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 0-38 30543688-1 2018 Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) is an important susceptibility locus for nicotine addiction and lung cancer. Nicotine 89-97 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 40-46 30453884-0 2018 Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence. Nicotine 82-90 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 66-72 30453884-1 2018 BACKGROUND: The CHRNA5/A3/B4 gene locus is associated with nicotine dependence and other smoking related disorders. Nicotine 59-67 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 16-22 30453884-4 2018 Searching for variants with evidence of regulatory functions, we have reported interactions between CHRNA5 and CHRNA3 enhancer variants (tagged by rs880395 and rs1948, respectively) and rs16969968, forming 3-SNP haplotypes and diplotypes that may more accurately reflect the cluster"s combined effects on nicotine dependence (Barrie et al., Hum Mutat 38:112-9, 2017). Nicotine 305-313 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 100-106 30453884-10 2018 CONCLUSIONS: These results indicate rs4887074 is associated with CHRNB4 expression, and along with two regulatory variants of CHRNA3 and CHRNA5, modulates the effect of rs16969968 on nicotine dependence risk. Nicotine 183-191 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 137-143 30829278-2 2018 Functional polymorphism in nicotinic acetylcholine receptor alpha-5 subunit gene (CHRNA5 c.1192G>A; rs16969968) is associated with nicotine dependence and risk of lung cancer. Nicotine 134-142 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 82-88 28972577-4 2018 In this largest-ever GWAS meta-analysis for nicotine dependence and the largest-ever cross-ancestry GWAS meta-analysis for any smoking phenotype, we reconfirmed the well-known CHRNA5-CHRNA3-CHRNB4 genes and further yielded a novel association in the DNA methyltransferase gene DNMT3B. Nicotine 44-52 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 176-182 29573323-0 2018 The interaction of the Chrna5 D398N variant with developmental nicotine exposure. Nicotine 63-71 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 23-29 29573323-1 2018 A single nucleotide polymorphism (SNP) in CHRNA5 (rs16969968, change from an aspartic acid [D] to asparagine [N] at position 398 of the human alpha5 nicotinic acetylcholine receptor subunit) has been associated with increased risk for nicotine dependence. Nicotine 235-243 cholinergic receptor nicotinic alpha 5 subunit Homo sapiens 42-48