PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28668504-3 2017 Some studies show that the 5-HT2A, 5-HT2C, and 5-HT3 receptors have a central role in the induction and expression of nicotine-induced locomotor sensitization. Nicotine 118-126 5-hydroxytryptamine receptor 2A Rattus norvegicus 27-33 31585211-0 2019 Inverse agonists of the 5-HT2A receptor reduce nicotine withdrawal signs in rats. Nicotine 47-55 5-hydroxytryptamine receptor 2A Rattus norvegicus 24-30 31585211-1 2019 Previous work has shown that chronic nicotine administration causes adaptive changes in 5-HT2A receptor expression. Nicotine 37-45 5-hydroxytryptamine receptor 2A Rattus norvegicus 88-94 31585211-2 2019 Based on this relationship, it was hypothesized that inactivating 5-HT2A receptors with the inverse agonists pimavanserin and volinanserin (MDL100907), would reduce the symptoms of nicotine withdrawal syndrome. Nicotine 181-189 5-hydroxytryptamine receptor 2A Rattus norvegicus 66-72 31585211-12 2019 The results suggest that the 5-HT2A receptor contributes to mediating nicotine withdrawal syndrome, and thus represents a potential target for interventions to aid smoking cessation. Nicotine 70-78 5-hydroxytryptamine receptor 2A Rattus norvegicus 29-35 26031442-5 2015 Nicotine withdrawal increased [(3)H]ketanserin binding to 5-HT2A receptors in the ventral tegmental area and ventral dentate gyrus, yet decreased binding in the nucleus accumbens shell. Nicotine 0-8 5-hydroxytryptamine receptor 2A Rattus norvegicus 58-64 26031442-10 2015 These results show that the reduction in the 5-HT2A receptor transcript level may be an auto-regulatory response to the increased receptor density in the hippocampus and ventral tegmental area during nicotine withdrawal, while decreased 5-HT2C receptor mRNA editing may explain the reduction in receptor labeling in the hippocampus. Nicotine 200-208 5-hydroxytryptamine receptor 2A Rattus norvegicus 45-51 26031442-12 2015 Here, we show that the reduction in 5-HT2A receptor transcript level may be an auto-regulatory response to the increased receptor number in the hippocampus and ventral tegmental area during nicotine withdrawal, while attenuated 5-HT2C receptor mRNA editing in the hippocampus might explain reduced inverse agonist binding to 5-HT2C receptor and suggest a shift toward a population of more active receptors. Nicotine 190-198 5-hydroxytryptamine receptor 2A Rattus norvegicus 36-42 20153341-0 2010 Effects of serotonin (5-HT)2 receptor ligands on depression-like behavior during nicotine withdrawal. Nicotine 81-89 5-hydroxytryptamine receptor 2A Rattus norvegicus 11-37 25933953-2 2015 In the present study we used male rats to verify the hypothesis that the binding pattern of 5-HT2A and 5-HT2C receptors in the brain is altered by chronic nicotine treatment in different environments. Nicotine 155-163 5-hydroxytryptamine receptor 2A Rattus norvegicus 92-104 25933953-5 2015 RESULTS: Repeated treatment with nicotine in home cages evoked significant increases in [(3)H]ketanserin binding to 5-HT2A receptors in the prefrontal cortex, striatal subregions and ventral tegmental area as well as reductions in [(3)H]mesulergine binding to 5-HT2C receptors in subregions of the prefrontal cortex. Nicotine 33-41 5-hydroxytryptamine receptor 2A Rattus norvegicus 116-122 25933953-6 2015 In contrast, nicotine paired with environmental context produced robust increases in 5-HT2A receptor labeling in the infralimbic cortex and decreased [(3)H]ketanserin binding in striatal subregions and ventral tegmental area; 5-HT2C receptor labeling in the prefrontal cortex fell. Nicotine 13-21 5-hydroxytryptamine receptor 2A Rattus norvegicus 85-91 25933953-7 2015 CONCLUSIONS: The present data indicate that chronic nicotine administration in home cages induces bi-directional neuroplastic changes within 5-HT2A and 5-HT2C receptors in the prefrontal cortex. Nicotine 52-60 5-hydroxytryptamine receptor 2A Rattus norvegicus 141-153 25933953-8 2015 Pairing the nicotine with environmental context potentiates the neuroplastic response in the latter region and evokes opposite changes in 5-HT2A receptor binding in striatal and tegmental regions compared with nicotine administered in the absence of the context, indicating a modulatory role of environmental context in the expression of nicotine-induced sensitization. Nicotine 12-20 5-hydroxytryptamine receptor 2A Rattus norvegicus 138-144 20196140-0 2010 Differential effects of serotonin (5-HT)2 receptor-targeting ligands on locomotor responses to nicotine-repeated treatment. Nicotine 95-103 5-hydroxytryptamine receptor 2A Rattus norvegicus 24-50 15565434-1 2005 RATIONALE: Reports have indicated that administration of nicotine inhibits, while withdrawal of chronically administered nicotine augments effects of serotonergic 5HT2A/2C agonists. Nicotine 121-129 5-hydroxytryptamine receptor 2A Rattus norvegicus 163-168 17617403-1 2007 The present study tested the hypothesis that serotonergic (5-HT) 5-HT2A or 5-HT2C receptors or their pharmacological stimulation modulated the discriminative stimulus effects of nicotine in male Wistar rats. Nicotine 178-186 5-hydroxytryptamine receptor 2A Rattus norvegicus 65-71 19347958-0 2009 Interactions of serotonin (5-HT)2 receptor-targeting ligands and nicotine: locomotor activity studies in rats. Nicotine 65-73 5-hydroxytryptamine receptor 2A Rattus norvegicus 16-42 18950618-7 2008 Ketanserin, a 5-HT2a and 5-HT2c receptor antagonist, significantly attenuates nicotine effects on attention and memory. Nicotine 78-86 5-hydroxytryptamine receptor 2A Rattus norvegicus 14-40 15565434-2 2005 OBJECTIVE: It was our objective to determine whether 5HT2A/2C agonists can modulate the discriminative stimulus effects of nicotine in rats or its locomotor activity effects in mice. Nicotine 123-131 5-hydroxytryptamine receptor 2A Rattus norvegicus 53-58 15565434-10 2005 CONCLUSIONS: These results indicate that activation of serotonin 5HT2A/2C receptors can blunt the discriminative stimulus and locomotor activity effects of nicotine and presents the possibility that activation of these receptors might also be able to attenuate other effects of nicotine. Nicotine 156-164 5-hydroxytryptamine receptor 2A Rattus norvegicus 65-70 15565434-10 2005 CONCLUSIONS: These results indicate that activation of serotonin 5HT2A/2C receptors can blunt the discriminative stimulus and locomotor activity effects of nicotine and presents the possibility that activation of these receptors might also be able to attenuate other effects of nicotine. Nicotine 278-286 5-hydroxytryptamine receptor 2A Rattus norvegicus 65-70