PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25293312-2 2015 The mu-opioid receptor (MOR), encoded by OPRM1, contributes to regulate the analgesic response to pain and also controls the rewarding effects of many drugs of abuse, including opioids, nicotine, and alcohol. Nicotine 186-194 opioid receptor mu 1 Homo sapiens 4-22 32975784-2 2021 The mu-opioid receptor (MOR ), encoded by OPRM1 , contributes to regulate the analgesic response to pain and also controls the rewarding effects of many drugs of abuse, including opioids, nicotine, and alcohol. Nicotine 188-196 opioid receptor mu 1 Homo sapiens 4-22 32975784-2 2021 The mu-opioid receptor (MOR ), encoded by OPRM1 , contributes to regulate the analgesic response to pain and also controls the rewarding effects of many drugs of abuse, including opioids, nicotine, and alcohol. Nicotine 188-196 opioid receptor mu 1 Homo sapiens 24-27 32975784-2 2021 The mu-opioid receptor (MOR ), encoded by OPRM1 , contributes to regulate the analgesic response to pain and also controls the rewarding effects of many drugs of abuse, including opioids, nicotine, and alcohol. Nicotine 188-196 opioid receptor mu 1 Homo sapiens 42-47 29431852-12 2018 Compared to previous work on the OPRM1 A118G SNP, it appears that nicotine-use might be a more salient predictor of naltrexone treatment response. Nicotine 66-74 opioid receptor mu 1 Homo sapiens 33-38 29137427-0 2017 Association of opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with nicotine dependence. Nicotine 80-88 opioid receptor mu 1 Homo sapiens 15-35 29137427-0 2017 Association of opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with nicotine dependence. Nicotine 80-88 opioid receptor mu 1 Homo sapiens 37-42 29137427-1 2017 Background and Object: Whether opioid-receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) is associated with nicotine dependence is controversial. Nicotine 110-118 opioid receptor mu 1 Homo sapiens 31-51 29137427-1 2017 Background and Object: Whether opioid-receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) is associated with nicotine dependence is controversial. Nicotine 110-118 opioid receptor mu 1 Homo sapiens 53-58 25941919-2 2015 The mu-opioid receptor (OPRM1) binds the endogenous opioid peptide beta-endorphin and mediates the reinforcing effects of nicotine, while the GluR5 kainate receptor subunit (encoded by GRIK1 gene), a binding site for known mediators of glutamate neurotransmission, potentially affects the glutaminergic system that is also indirectly implicated in the reward system. Nicotine 122-130 opioid receptor mu 1 Homo sapiens 24-29 25941919-9 2015 In the present study, we have shown that gene-gene interaction of components of different systems associated with nicotine reinforcing effects, such as OPRM1 and GRIK1, rather than one gene polymorphism, is associated with smoking behavior. Nicotine 114-122 opioid receptor mu 1 Homo sapiens 152-157 32763540-3 2020 Rewarding effects of nicotine from cigarettes are associated, among others, with mu-opioid receptors encoded by the OPRM1 gene. Nicotine 21-29 opioid receptor mu 1 Homo sapiens 116-121 32763540-8 2020 This is the first study to reveal that nicotine dependence is associated with the GC haplotype of the OPRM1 rs1799971 and rs510769 in all subjects or specifically in healthy controls. Nicotine 39-47 opioid receptor mu 1 Homo sapiens 102-107 31206155-2 2019 METHODS: The study"s primary objective was to examine the association of the Asn40Asp OPRM1 single nucleotide polymorphism (SNP) with naltrexone"s effects on smoking quit rate, weight gain, and heavy drinking behavior during a double-blind, randomized clinical trial in 280 adult DSM-IV nicotine-dependent participants. Nicotine 287-295 opioid receptor mu 1 Homo sapiens 86-91 27095017-11 2016 It also suggests that nicotine non-specific elements of the smoking experience have an important role in regulating MOR-mediated neurotransmission, and in turn modulating withdrawal-induced craving ratings. Nicotine 22-30 opioid receptor mu 1 Homo sapiens 116-119 27459726-1 2016 It has been proposed that vulnerability to nicotine addiction is moderated by variation at the mu-opioid receptor locus (OPRM1), but results from human studies vary and prospective studies based on genotype are lacking. Nicotine 43-51 opioid receptor mu 1 Homo sapiens 121-126 25293312-2 2015 The mu-opioid receptor (MOR), encoded by OPRM1, contributes to regulate the analgesic response to pain and also controls the rewarding effects of many drugs of abuse, including opioids, nicotine, and alcohol. Nicotine 186-194 opioid receptor mu 1 Homo sapiens 24-27 25293312-2 2015 The mu-opioid receptor (MOR), encoded by OPRM1, contributes to regulate the analgesic response to pain and also controls the rewarding effects of many drugs of abuse, including opioids, nicotine, and alcohol. Nicotine 186-194 opioid receptor mu 1 Homo sapiens 41-46 25493427-5 2014 Interestingly, we showed that in smokers MOR availability in bilateral superior temporal cortices during the placebo condition was negatively correlated with scores on the Fagerstrom Test for Nicotine Dependence (FTND). Nicotine 192-200 opioid receptor mu 1 Homo sapiens 41-44 24446757-8 2014 CONCLUSION: Although preliminary, these findings suggest that exposure to environmental smoking and polymorphisms in the OPRM1 and DRD2 gene may affect initial sensitivity to nicotine, an early phenotype of the risk of dependence. Nicotine 175-183 opioid receptor mu 1 Homo sapiens 121-126 24201053-4 2014 The mu-opioid receptor (MOR), encoded by OPRM1, naturally regulates the analgesic response to pain and also controls the rewarding effects of many drugs of abuse, including opioids, nicotine, and alcohol. Nicotine 182-190 opioid receptor mu 1 Homo sapiens 4-22 24201053-4 2014 The mu-opioid receptor (MOR), encoded by OPRM1, naturally regulates the analgesic response to pain and also controls the rewarding effects of many drugs of abuse, including opioids, nicotine, and alcohol. Nicotine 182-190 opioid receptor mu 1 Homo sapiens 24-27 24201053-4 2014 The mu-opioid receptor (MOR), encoded by OPRM1, naturally regulates the analgesic response to pain and also controls the rewarding effects of many drugs of abuse, including opioids, nicotine, and alcohol. Nicotine 182-190 opioid receptor mu 1 Homo sapiens 41-46 22862850-1 2014 The A118G single nucleotide polymorphism (SNP) of the human mu-opioid receptor (MOPR) gene (OPRM1) was associated with heightened dopamine release by alcohol intake, better treatment outcome for nicotine and alcohol addiction, and reduced analgesic responses to morphine. Nicotine 195-203 opioid receptor mu 1 Homo sapiens 92-97 21507151-1 2013 The mu-opioid receptor encoded by the gene OPRM1 plays a primary role in opiate, alcohol, cocaine and nicotine addiction. Nicotine 102-110 opioid receptor mu 1 Homo sapiens 43-48 24084318-5 2013 An involvement of MOR and DOR, but not KOR, in the development of nicotine physical dependence or in abstinence-induced withdrawal was thus demonstrated in a sensitive and facile invertebrate model. Nicotine 66-74 opioid receptor mu 1 Homo sapiens 18-21 22640768-10 2012 A few well-validated, specific predictors such as OPRM1, ADH1B, ALDH2, CHRNA5, and CYP26 have been identified and can provide some specific guidance, for example, to understand alcohol-related flushing and upper GI cancer risk (ADH1B and AKLDH2), variation in nicotine metabolism (CYP26), and, potentially, naltrexone treatment response (OPRM1). Nicotine 260-268 opioid receptor mu 1 Homo sapiens 50-55 22389047-2 2012 Endogenous opioid neurotransmission, and the mu-opioid receptor (MOR) in particular, plays a role in affective regulation and is modulated by nicotine. Nicotine 142-150 opioid receptor mu 1 Homo sapiens 45-63 22389047-2 2012 Endogenous opioid neurotransmission, and the mu-opioid receptor (MOR) in particular, plays a role in affective regulation and is modulated by nicotine. Nicotine 142-150 opioid receptor mu 1 Homo sapiens 65-68 23223006-0 2013 OPRM1 genetic polymorphisms are associated with the plasma nicotine metabolite cotinine concentration in methadone maintenance patients: a cross sectional study. Nicotine 59-67 opioid receptor mu 1 Homo sapiens 0-5 22676196-0 2012 A systematic review of the A118G (Asn40Asp) variant of OPRM1 in relation to smoking initiation, nicotine dependence and smoking cessation. Nicotine 96-104 opioid receptor mu 1 Homo sapiens 55-60 21576462-1 2011 Evidence points to the endogenous opioid system, and the mu-opioid receptor (MOR) in particular, in mediating the rewarding effects of drugs of abuse, including nicotine. Nicotine 161-169 opioid receptor mu 1 Homo sapiens 57-75 21576462-6 2011 Among G allele carriers, the extent of subjective reward difference (denicotinized versus nicotine cigarette) was associated significantly with MOR BP(ND) difference in right amygdala, caudate, anterior cingulate cortex, and thalamus. Nicotine 90-98 opioid receptor mu 1 Homo sapiens 144-147 21576462-1 2011 Evidence points to the endogenous opioid system, and the mu-opioid receptor (MOR) in particular, in mediating the rewarding effects of drugs of abuse, including nicotine. Nicotine 161-169 opioid receptor mu 1 Homo sapiens 77-80 17224915-3 2007 Our results indicate that OPRM1 genotype may moderate the effect of transdermal nicotine patch compared to placebo during active treatment, with a benefit of active NRT treatment evident in the OPRM1 AA genotype group only and those carrying one or more copies of the G allele demonstrating no benefit of active NRT versus placebo patch. Nicotine 80-88 opioid receptor mu 1 Homo sapiens 26-31 19959688-7 2009 Evaluation of 18 OPRM1 SNPs via the family-based association test with the nicotine withdrawal sensitivity score identified eight tagging SNPs with global P values <0.05 and false discovery rate Q values <0.06. Nicotine 75-83 opioid receptor mu 1 Homo sapiens 17-22 19959688-8 2009 CONCLUSION: An increased risk of relapse, suggestive linkage at chr6q26, and nominally significant association with multiple OPRM1 SNPs were found with Rasch-modeled nicotine withdrawal sensitivity scores in a multiplex smoking pedigree sample. Nicotine 166-174 opioid receptor mu 1 Homo sapiens 125-130 19959688-9 2009 Future studies should attempt to replicate these findings and investigate the relationship between nicotine withdrawal symptoms and variation at OPRM1. Nicotine 99-107 opioid receptor mu 1 Homo sapiens 145-150 22046326-8 2011 Overall, our results suggest that genetic variants potentially involved in nicotine metabolization (mainly, CYP2A6 polymorphisms) are those showing the strongest association with smoking-related phenotypes, as opposed to genetic variants influencing the brain effects of nicotine, e.g., through nicotinic acetylcholine (CHRNA5), serotoninergic (HTR2A), opioid (OPRM1) or cannabinoid receptors (CNR1). Nicotine 75-83 opioid receptor mu 1 Homo sapiens 361-366 16887046-4 2006 Additionally, the OPRM1 gene is located in a region showing linkage to nicotine dependence. Nicotine 71-79 opioid receptor mu 1 Homo sapiens 18-23 16960700-0 2006 Association of OPRM1 A118G variant with the relative reinforcing value of nicotine. Nicotine 74-82 opioid receptor mu 1 Homo sapiens 15-20 16960700-6 2006 RESULTS: The relative reinforcing value of nicotine (number of nicotine cigarette puffs) was predicted by a significant OPRM1 by gender interaction. Nicotine 43-51 opioid receptor mu 1 Homo sapiens 120-125 16960700-6 2006 RESULTS: The relative reinforcing value of nicotine (number of nicotine cigarette puffs) was predicted by a significant OPRM1 by gender interaction. Nicotine 63-71 opioid receptor mu 1 Homo sapiens 120-125 16960700-10 2006 CONCLUSIONS: This study provides initial evidence for an association of the OPRM1 A118G variant with nicotine reinforcement in women. Nicotine 101-109 opioid receptor mu 1 Homo sapiens 76-81 16887046-6 2006 To investigate whether OPRM1 contributes to the susceptibility of smoking initiation and nicotine dependence, we genotyped 11 SNPs in the gene for 688 Caucasian subjects of lifetime smokers and nonsmokers. Nicotine 89-97 opioid receptor mu 1 Homo sapiens 23-28 16887046-10 2006 These results suggest that OPRM1 may be involved in smoking initiation and nicotine dependence. Nicotine 75-83 opioid receptor mu 1 Homo sapiens 27-32 15007373-0 2004 The functional mu opioid receptor (OPRM1) Asn40Asp variant predicts short-term response to nicotine replacement therapy in a clinical trial. Nicotine 91-99 opioid receptor mu 1 Homo sapiens 35-40