PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20164553-8	2010	In our cross-sectional study, use of oral snuff also yielded statistically significantly increased serum TTR concentrations and nicotine has been associated with decreased risk for AD and to upregulate the TTR gene in choroid plexus but not in the liver, another source of serum TTR.	Nicotine	128-136	transthyretin	Homo sapiens	206-209	
20164553-8	2010	In our cross-sectional study, use of oral snuff also yielded statistically significantly increased serum TTR concentrations and nicotine has been associated with decreased risk for AD and to upregulate the TTR gene in choroid plexus but not in the liver, another source of serum TTR.	Nicotine	128-136	transthyretin	Homo sapiens	206-209	
35395343-9	2022	RESULTS: Nicotine blocks uptake of transthyretin-T4 by human placental trophoblast cells.	Nicotine	9-17	transthyretin	Homo sapiens	35-48	
35395343-10	2022	Nicotine reduces the expression of the trophoblast scavenger receptor class B type 1 (SR-B1) that plays a role in transthyretin-T4 uptake.	Nicotine	0-8	transthyretin	Homo sapiens	114-127	
35395343-11	2022	Molecular dynamic modelling suggests that when T4 is bound to transthyretin, nicotine binding increases tetramer stability, reducing the ability of the transthyretin-T4 complex to enter trophoblast cells.	Nicotine	77-85	transthyretin	Homo sapiens	62-75	
35395343-12	2022	CONCLUSION: Our data suggest that nicotine exposure during pregnancy reduces transplacental transport of transthyretin and T4 to the placenta and developing fetus.	Nicotine	34-42	transthyretin	Homo sapiens	105-118