PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31005665-10 2019 Our results showed that nicotine significantly reduced hyperalgesia in mice that received acute or repeated rapamycin injections, and reversed the effects of rapamycin on the phosphorylation of S6K, 4E-BP1, insulin receptor substrate-1 (IRS-1) at Ser636/639, AKT at Ser473, and ERK at Thr202/Tyr204. Nicotine 24-32 eukaryotic translation initiation factor 4E binding protein 1 Mus musculus 199-205