PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34502498-0 2021 Nicotine Neurotoxicity Involves Low Wnt1 Signaling in Spinal Locomotor Networks of the Postnatal Rodent Spinal Cord. Nicotine 0-8 Wnt family member 1 Rattus norvegicus 36-40 34502498-6 2021 Conversely, nicotine (0.5-1 microM) preserved neurons throughout the spinal cord and strongly activated the Wnt1 signaling pathway. Nicotine 12-20 Wnt family member 1 Rattus norvegicus 108-112 34502498-9 2021 When combining nicotine with kainate, the activation of Wnt1 was reduced compared to kainate/sham. Nicotine 15-23 Wnt family member 1 Rattus norvegicus 56-60 34502498-10 2021 The present results suggest that high dose nicotine was neurotoxic to central and ventral spinal neurons as the neuroprotective role of Wnt signaling became attenuated. Nicotine 43-51 Wnt family member 1 Rattus norvegicus 136-139