PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25050820-0 2014 Central amygdala nicotinic and 5-HT1A receptors mediate the reversal effect of nicotine and MDMA on morphine-induced amnesia. Nicotine 79-87 5-hydroxytryptamine receptor 1A Rattus norvegicus 31-37 25050820-1 2014 The present study was designed to investigate possible involvement of the central amygdala (CeA) nicotinic acetylcholine (nACh) and 5-hydroxytryptamine 1A (5-HT1A) receptors in the reversal effect of nicotine and 3,4-methylenedioxy-N-methylamphetamine (MDMA or ecstasy) on morphine-induced amnesia. Nicotine 200-208 5-hydroxytryptamine receptor 1A Rattus norvegicus 132-154 25050820-1 2014 The present study was designed to investigate possible involvement of the central amygdala (CeA) nicotinic acetylcholine (nACh) and 5-hydroxytryptamine 1A (5-HT1A) receptors in the reversal effect of nicotine and 3,4-methylenedioxy-N-methylamphetamine (MDMA or ecstasy) on morphine-induced amnesia. Nicotine 200-208 5-hydroxytryptamine receptor 1A Rattus norvegicus 156-162 23872451-8 2013 The inhibitory effect of nicotine upon 5-HT DRN neurons was dependent on serotonin release inside the DRN, since it was converted into a stimulatory response by the selective antagonist of 5-HT1A receptors N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridyl)cyclohexanecarboxamide (WAY100635, 25nM). Nicotine 25-33 5-hydroxytryptamine receptor 1A Rattus norvegicus 189-195 23872451-11 2013 These data indicate that, in the experimental model of adrenalectomised rats implanted with corticosterone pellets, nicotine increases the function of 5-HT1A receptors of 5-HT DRN neurons. Nicotine 116-124 5-hydroxytryptamine receptor 1A Rattus norvegicus 151-157 21412223-0 2011 Nicotine alters limbic function in adolescent rat by a 5-HT1A receptor mechanism. Nicotine 0-8 5-hydroxytryptamine receptor 1A Rattus norvegicus 55-61 21412223-7 2011 Nicotine enhancement of cocaine self-administration and quinpirole-induced locomotor activity was blocked by co-administration of WAY 100 635 (N-{2-[4-(2-methoxyphenyl)-1-piperazinyl] ethyl}-N-(2-pyridinyl)cyclohexanecarboxamide), a selective serotonin 1A (5-HT1A) receptor antagonist. Nicotine 0-8 5-hydroxytryptamine receptor 1A Rattus norvegicus 257-263 21412223-10 2011 These findings indicate that early adolescent nicotine exposure uniquely alters limbic function by both 5-HT1A and non-5-HT1A receptor mechanisms. Nicotine 46-54 5-hydroxytryptamine receptor 1A Rattus norvegicus 104-110 21412223-10 2011 These findings indicate that early adolescent nicotine exposure uniquely alters limbic function by both 5-HT1A and non-5-HT1A receptor mechanisms. Nicotine 46-54 5-hydroxytryptamine receptor 1A Rattus norvegicus 119-125 20211707-4 2010 Males displayed persistent upregulation of 5HT(1A) and 5HT(2) receptors and the 5HT transporter, with a distinct hierarchy of effects: nicotine<dexamethasone<combined treatment. Nicotine 135-143 5-hydroxytryptamine receptor 1A Rattus norvegicus 43-49 17562392-5 2007 Prenatal nicotine exposure elicited persistent suppression of 5HT1A receptors and upregulation of 5HT2 receptors, effects that were selective for males and that first emerged in young adulthood. Nicotine 9-17 5-hydroxytryptamine receptor 1A Rattus norvegicus 62-67 17449445-4 2007 The co-administration of selective serotonin reuptake inhibitors with a serotonin-1A receptor antagonist, or the tricyclic antidepressant desipramine, or the atypical antidepressant bupropion ameliorated nicotine or amphetamine withdrawal in rats. Nicotine 204-212 5-hydroxytryptamine receptor 1A Rattus norvegicus 72-93 11377919-0 2001 Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats. Nicotine 101-109 5-hydroxytryptamine receptor 1A Rattus norvegicus 27-48 11412838-0 2001 Effects of 5-HT1A and 5-HT2 receptor agonists on the behavioral and neurochemical consequences of repeated nicotine treatment. Nicotine 107-115 5-hydroxytryptamine receptor 1A Rattus norvegicus 11-17 11412838-6 2001 Taken together, these findings suggest that the 5-HT1A and the 5-HT2 receptor subtypes are differentially involved in the effects of repeated nicotine on locomotor sensitization, behavioral inhibition and mesolimbic dopamine neurochemistry. Nicotine 142-150 5-hydroxytryptamine receptor 1A Rattus norvegicus 48-54 11029650-0 2000 The role of 5-HT1A receptors in mediating the anxiogenic effects of nicotine following lateral septal administration. Nicotine 68-76 5-hydroxytryptamine receptor 1A Rattus norvegicus 12-18 11029650-1 2000 The purpose of the present study was to determine the role of the 5-HT1A receptors in the lateral septum in the mediation of the anxiogenic effects of nicotine in the social interaction and elevated plus maze tests of anxiety in the rat. Nicotine 151-159 5-hydroxytryptamine receptor 1A Rattus norvegicus 66-72 11029650-7 2000 The effects of 8-OH-DPAT demonstrate that stimulation of 5-HT1A receptors in the lateral septum has anxiogenic effects in two animal tests and that the anxiogenic effects of nicotine are mediated at least in part by these 5-HT1A receptors. Nicotine 174-182 5-hydroxytryptamine receptor 1A Rattus norvegicus 222-228 10837844-4 2000 However, the anxiogenic effects of mecamylamine and nicotine in the dorsal hippocampus are blocked by coadministration of the 5-HT(1A) receptor antagonist, WAY 100635, suggesting that both of these compounds act by enhancing hippocampal serotonergic transmission, thereby stimulating postsynaptic 5-HT(1A) receptors. Nicotine 52-60 5-hydroxytryptamine receptor 1A Rattus norvegicus 126-133 10837844-4 2000 However, the anxiogenic effects of mecamylamine and nicotine in the dorsal hippocampus are blocked by coadministration of the 5-HT(1A) receptor antagonist, WAY 100635, suggesting that both of these compounds act by enhancing hippocampal serotonergic transmission, thereby stimulating postsynaptic 5-HT(1A) receptors. Nicotine 52-60 5-hydroxytryptamine receptor 1A Rattus norvegicus 297-304 9372532-0 1997 Nicotine withdrawal leads to increased sensitivity of serotonergic neurons to the 5-HT1A agonist 8-OH-DPAT. Nicotine 0-8 5-hydroxytryptamine receptor 1A Rattus norvegicus 82-88 9266775-6 1997 Pretreatment with the 5-HT-1A agonists (+)8-OH-DPAT (0.001-0.1 mg/kg) and LY274600 (0.3-3.0 mg/kg) either had no affect or exacerbated the nicotine-withdrawal-enhanced startle response. Nicotine 139-147 5-hydroxytryptamine receptor 1A Rattus norvegicus 22-29 9266775-7 1997 Pretreatment with the 5-HT-1A antagonists NAN-190 (1-3 mg/kg), LY206130 (1-10 mg/kg), or WAY-100635 (0.1-1.0 mg/kg) blocked the increase in the startle response caused by nicotine withdrawal at doses that had no effect on baseline startle responses. Nicotine 171-179 5-hydroxytryptamine receptor 1A Rattus norvegicus 22-29 9266775-8 1997 These data indicate that 5-HT-1A receptors play a role in the neurophysiology of nicotine withdrawal. Nicotine 81-89 5-hydroxytryptamine receptor 1A Rattus norvegicus 25-32