PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27566293-8 2016 In addition, pesticides inhibit the ubiquitin proteasome system (UPS) and consequently increase proteins of the shelterin complex, avoiding the access of telomerase in telomere and, nicotine activates UPS mechanisms and promotes the degradation of human telomerase reverse transcriptase (hTERT), decreasing telomerase activity. Nicotine 182-190 telomerase reverse transcriptase Homo sapiens 288-293 17331439-0 2007 [Effects of arecoline and nicotine on the expression of hTERT in oral keratinocytes]. Nicotine 26-34 telomerase reverse transcriptase Homo sapiens 56-61 17331439-1 2007 OBJECTIVE: To investigate the effects of arecoline and nicotine on the expression of human telomerase reverse transcriptase (hTERT) mRNA and protein in cultured normal human oral keratinocytes (KC). Nicotine 55-63 telomerase reverse transcriptase Homo sapiens 125-130 17331439-5 2007 Nicotine (0.025 g/L) increased hTERT mRNA and protein expression of KC induced by arecoline. Nicotine 0-8 telomerase reverse transcriptase Homo sapiens 31-36 17331439-8 2007 hTERT over-expression induced by arecoline and nicotine may play an important role in the malignant transformation of oral submucous fibrosis. Nicotine 47-55 telomerase reverse transcriptase Homo sapiens 0-5