PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12515313-1	2002	Compound 24, an alkyl-substituted amino acid amide, previously found to activate pertussis toxin-sensitive G proteins in cell membranes and membrane protein fractions, was used as a tool to determine the mechanism/location of nicotine inhibition of amyloid beta peptide-stimulated phospholipase A2 and D activities in a human neuroblastoma cell line, LA-N-2, in vitro.	Nicotine	226-234	phospholipase A2 group IB	Homo sapiens	281-297	
31492433-1	2019	We investigated the relationship between the rs10798059 (BanI) and rs4375 polymorphisms in the phospholipase A2 (PLA2)G4A and PLA2G6 genes and the risk of nicotine dependence in 263 Croatian patients with schizophrenia.	Nicotine	155-163	phospholipase A2 group IB	Homo sapiens	95-111	
9873232-3	1999	Therefore, we studied: (a) the influence of nicotine and cotinine on the effects of PGE2 on placental vasculature in perfused human placental cotyledon, and (b) the activation of placental phospholipase A2 (PLA2) by nicotine and cotinine using 1-palmitoyl-2-[1-14C]arachidonyl-phosphatidylethanolamine (PE, 2.2 nmol) as substrate.	Nicotine	216-224	phospholipase A2 group IB	Homo sapiens	189-205	
9873232-6	1999	Nicotine (2 microg/ml) prevented the effect of PGE2; (2) both cotinine (EC50 470-500 fmol/l) and nicotine (EC50 18-32 pmol/l) activated PLA2 in human placental tissues.	Nicotine	0-8	phospholipase A2 group IB	Homo sapiens	136-140	
9873232-6	1999	Nicotine (2 microg/ml) prevented the effect of PGE2; (2) both cotinine (EC50 470-500 fmol/l) and nicotine (EC50 18-32 pmol/l) activated PLA2 in human placental tissues.	Nicotine	97-105	phospholipase A2 group IB	Homo sapiens	136-140	
9873232-7	1999	These observations indicated that cotinine was more potent than in nicotine activating PLA2 and potentiating the vasoconstrictive effects of PGE2 on fetal placental circulation.	Nicotine	67-75	phospholipase A2 group IB	Homo sapiens	87-91	
9067314-0	1997	Nicotine-induced inhibition of neuronal phospholipase A2.	Nicotine	0-8	phospholipase A2 group IB	Homo sapiens	40-56	
9067314-7	1997	In fact, using the fluorogenic phospholipase A2 substrate 1,2-bis-(1-pyrenedecanoyl)-sn-glycero-3-phosphocholine, (-)-nicotine was found to inhibit both particulate and soluble phospholipase A2 activities from striatal neurons.	Nicotine	114-126	phospholipase A2 group IB	Homo sapiens	31-47	
9067314-7	1997	In fact, using the fluorogenic phospholipase A2 substrate 1,2-bis-(1-pyrenedecanoyl)-sn-glycero-3-phosphocholine, (-)-nicotine was found to inhibit both particulate and soluble phospholipase A2 activities from striatal neurons.	Nicotine	114-126	phospholipase A2 group IB	Homo sapiens	177-193	
9685679-4	1998	(-)Nicotine inhibits the AbetaP activation of phospholipase A2, with an IC50 of 76 microM and of phospholipase D with an IC50 of 252 microM.	Nicotine	3-11	phospholipase A2 group IB	Homo sapiens	46-62	
9685679-8	1998	Exposure of LA-N-2 cells to (-)nicotine for 2 h resulted in the blockade of phospholipase A2 activation by kainate and AbetaP but did not affect the ability of quisqualate and AbetaP to activate phospholipase D. These data suggest that if the nicotine inhibition of AbetaP activations is receptor occupancy mediated then it is by an atypical receptor type.	Nicotine	31-39	phospholipase A2 group IB	Homo sapiens	76-92