PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18723372-6	2008	Pretreatment of cells with nicotine blocked LPS-induced p42/44 MAPK and S6K1 as well as iNOS promoter activity.	Nicotine	27-35	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	72-76	
18723372-7	2008	Furthermore, we found that LPS-induced phosphorylation of STAT3 at serine 727 is mediated by S6K1-p42/44 MAPK pathway, and this STAT3 phosphorylation was also blocked by nicotine.	Nicotine	170-178	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	93-97	
18723372-9	2008	Taken together, our results suggest that nicotine inhibits LPS-induced NO synthesis through suppression of S6K1-p42/44 MAPK pathway and phosphorylation of STAT3 in Raw 264.7 cells.	Nicotine	41-49	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	107-111	
31005665-10	2019	Our results showed that nicotine significantly reduced hyperalgesia in mice that received acute or repeated rapamycin injections, and reversed the effects of rapamycin on the phosphorylation of S6K, 4E-BP1, insulin receptor substrate-1 (IRS-1) at Ser636/639, AKT at Ser473, and ERK at Thr202/Tyr204.	Nicotine	24-32	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	194-197	
18723372-0	2008	Inhibition of lipopolysaccharide-induced nitric oxide synthesis by nicotine through S6K1-p42/44 MAPK pathway and STAT3 (Ser 727) phosphorylation in Raw 264.7 cells.	Nicotine	67-75	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	84-88