PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18571742-1	2008	We recently found that the interfering peptide Tat-3L4F is able not only to disrupt the protein-protein interaction of PTEN (phosphatase and tensin homologue deleted on chromosome 10) with the serotonin 5-HT2C receptor in the rat ventral tegmental area (VTA) but also to suppress the conditioned place preference induced by cannabinoid and nicotine without significant effects on anxiety, feeding behavior and motor activity.	Nicotine	340-348	phosphatase and tensin homolog	Rattus norvegicus	119-123	
18772044-4	2008	Systemic or intra-amygdaloid application of the interfering peptide Tat-3L4F is able to disrupt PTEN coupling with 5-HT2cR in the rat VTA, resulting both in a suppression of the increased firing rate of VTA dopaminergic neurons induced by Delta 9-tetrahydrocannabinol (THC), the psychoactive ingredient of marijuana, and in a blockade of the conditioned place preference induced by THC and nicotine [Ji, S.P.	Nicotine	390-398	phosphatase and tensin homolog	Rattus norvegicus	96-100	
16331670-0	2006	Association of the phosphatase and tensin homolog gene (PTEN) with smoking initiation and nicotine dependence.	Nicotine	90-98	phosphatase and tensin homolog	Rattus norvegicus	56-60	
16331670-1	2006	Since PTEN (phosphatase and tensin homolog) has elevated expression in rat brain (amygdala) after chronic administration of nicotine and the PTEN gene is located in the vicinity of the chromosome 10q23 linkage peak in a genome-scan study of nicotine dependence, PTEN seems a plausible candidate gene for smoking behavior.	Nicotine	124-132	phosphatase and tensin homolog	Rattus norvegicus	6-10	
16331670-1	2006	Since PTEN (phosphatase and tensin homolog) has elevated expression in rat brain (amygdala) after chronic administration of nicotine and the PTEN gene is located in the vicinity of the chromosome 10q23 linkage peak in a genome-scan study of nicotine dependence, PTEN seems a plausible candidate gene for smoking behavior.	Nicotine	241-249	phosphatase and tensin homolog	Rattus norvegicus	6-10	
16331670-1	2006	Since PTEN (phosphatase and tensin homolog) has elevated expression in rat brain (amygdala) after chronic administration of nicotine and the PTEN gene is located in the vicinity of the chromosome 10q23 linkage peak in a genome-scan study of nicotine dependence, PTEN seems a plausible candidate gene for smoking behavior.	Nicotine	241-249	phosphatase and tensin homolog	Rattus norvegicus	141-145	
16331670-1	2006	Since PTEN (phosphatase and tensin homolog) has elevated expression in rat brain (amygdala) after chronic administration of nicotine and the PTEN gene is located in the vicinity of the chromosome 10q23 linkage peak in a genome-scan study of nicotine dependence, PTEN seems a plausible candidate gene for smoking behavior.	Nicotine	241-249	phosphatase and tensin homolog	Rattus norvegicus	141-145	
16331670-8	2006	These results suggest that the PTEN gene may be involved in the etiology of both smoking initiation and nicotine dependence.	Nicotine	104-112	phosphatase and tensin homolog	Rattus norvegicus	31-35