PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23443505-8	2013	Compared with mono-culture systems, stimulation with nicotine caused an increased secretion of IL-1beta in serum of human PDL cell-CD4(+) T cell co-culture, and the expression of RANKL in human PDL cells was further upregulated co-cultured with CD4(+) T cells, while no differences were observed in the expression of OPG between the co-culture and mono-culture systems.	Nicotine	53-61	TNF receptor superfamily member 11b	Homo sapiens	317-320	
28901402-7	2017	CORM-3 attenuated the LPS- and nicotine-induced production of PGE2, COX-2 and RANKL in human PDLCs by releasing CO, and upregulated the expression of OPG.	Nicotine	31-39	TNF receptor superfamily member 11b	Homo sapiens	150-153	
19656028-4	2009	RESULTS: Nicotine treatment concomitantly downregulated the expression of OPG and osteoblastic differentiation markers, such as alkaline phosphatase, osteocalcin, and osteopontin, and upregulated the expression of RANKL.	Nicotine	9-17	TNF receptor superfamily member 11b	Homo sapiens	74-77	
16266722-2	2006	The present study was undertaken to determine the effect of nicotine and LPS on the expression of macrophage colony-stimulating factor (M-CSF), osteoprotegerin (OPG), and prostaglandin E2 (PGE2) in osteoblasts, and the indirect effect of nicotine and LPS on the formation of osteoclast-like cells.	Nicotine	60-68	TNF receptor superfamily member 11b	Homo sapiens	144-159	
16266722-2	2006	The present study was undertaken to determine the effect of nicotine and LPS on the expression of macrophage colony-stimulating factor (M-CSF), osteoprotegerin (OPG), and prostaglandin E2 (PGE2) in osteoblasts, and the indirect effect of nicotine and LPS on the formation of osteoclast-like cells.	Nicotine	60-68	TNF receptor superfamily member 11b	Homo sapiens	161-164	
16266722-8	2006	OPG expression increased in the initial stages of culture with nicotine and LPS but decreased in the later stages of culture.	Nicotine	63-71	TNF receptor superfamily member 11b	Homo sapiens	0-3