PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24044905-9	2014	Furthermore, the intervention of enalapril in nicotine-treated diabetic rat attenuated the testicular damage and restored sperm count, sperm DNA damage, as well as reduced the expression of NF-kappaB, COX-2, and TNF-alpha.	Nicotine	46-54	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	201-206	
24807738-1	2014	Previous studies have shown that rats subjected to subchronic treatment with nicotine experience changes in COX-2 (a marker of pro-inflammatory systems) and accumulate lipid hydroperoxides (a marker of oxidative stress) in the CNS (CNSMC, 2010; 10:180-206) (hippocampus, frontoparietal cortex and cerebellar cortex).	Nicotine	77-85	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	108-113	
18849602-6	2009	COX-2 expression was also determined by Western blot in the kidney cortex of rats treated with nicotine and in cultured human mesangial cells treated with nicotine.	Nicotine	95-103	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	0-5	
18849602-6	2009	COX-2 expression was also determined by Western blot in the kidney cortex of rats treated with nicotine and in cultured human mesangial cells treated with nicotine.	Nicotine	155-163	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	0-5	
18849602-8	2009	In nephritic rats, the administration of nicotine significantly increased fibronectin and COX-2 expression.	Nicotine	41-49	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	90-95	
34981020-8	2021	Nicotine cessation for 4 weeks caused a marked reduction in the expression of STAT1alpha protein, COX-2 and iNOS genes and oxidative stress.	Nicotine	0-8	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	98-103	
16150053-12	2005	These results suggest that nicotine prevented or reversed the adverse effects of celecoxib on spatial memory retention and protected or restored the immunostaining pattern of COX-2 neurons in the rat dorsal hippocampus.	Nicotine	27-35	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	175-180	
12120902-4	2002	In the present studies an involvement of adrenergic system and prostaglandins synthesized by constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2) in the nicotine-induced HPA response in rats was investigated.	Nicotine	173-181	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	159-164	
33352289-9	2021	Chronic nicotine administration led to an increase of microglial cells in the dorsal horn of the spinal cord and increased expression levels of the cytokines TNFalpha and COX-2.	Nicotine	8-16	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	171-176	
31841390-0	2020	COX-2 derived prostaglandins as mediators of the deleterious effects of nicotine in chronic kidney disease.	Nicotine	72-80	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	0-5	
31841390-2	2020	In previous studies, we showed that nicotine induces COX-2 expression in vivo and in vitro and that the administration of nicotine in vivo worsens the severity of renal injury in a model of sub-total renal ablation.	Nicotine	36-44	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	53-58	
31841390-9	2020	Treatment with the COX-2 inhibitor NS-398 resulted in complete inhibition of all prostaglandins studied and ameliorated renal injury and proteinuria in 5/6Nx rats on nicotine but not in 5/6 Nx rats on tap water.	Nicotine	166-174	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	19-24	
31841390-10	2020	Nicotine also reduced the expression of megalin in all groups examined which was partially prevented by COX-2 inhibition.	Nicotine	0-8	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	104-109