PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32362142-0	2020	Effects of peroxiredoxin 1 on nicotine induced apoptosis in mouse tongue.	Nicotine	30-38	peroxiredoxin 1	Mus musculus	11-26	
32362142-4	2020	We investigated expression of Prx1 and proteins in apoptosis-related downstream signaling by mitogen-activated protein kinases (MAPKs) in nicotine-treated tongue tissues of wild-type and Prx1 knockout (Prx1+-) mice; we also investigated these processes in mouse embryonic fibroblast (MEF) cells in vitro.	Nicotine	138-146	peroxiredoxin 1	Mus musculus	30-34	
32362142-5	2020	Nicotine increased the expression of Prx1 mRNA in tongue tissues in vivo.	Nicotine	0-8	peroxiredoxin 1	Mus musculus	37-41	
32362142-6	2020	The rate of apoptosis was similar among the nicotine-treated mice, nicotine-treated + Prx1+- mice and untreated controls.	Nicotine	67-75	peroxiredoxin 1	Mus musculus	86-90	
32362142-8	2020	In MEF cells, nicotine increased the expression of Prx1 and inhibited apoptosis and expression of p-p38 and p-JNK.	Nicotine	14-22	peroxiredoxin 1	Mus musculus	51-55	
32362142-10	2020	Nicotine-regulated apoptosis might occur via a Prx1-dependent pathway.	Nicotine	0-8	peroxiredoxin 1	Mus musculus	47-51	
31118684-0	2019	Nicotine promotes cervical metastasis of oral cancer by regulating peroxiredoxin 1 and epithelial-mesenchymal transition in mice.	Nicotine	0-8	peroxiredoxin 1	Mus musculus	67-82	
31118684-4	2019	In addition, we established a mouse model to confirm the roles of nicotine in regulating Ets1/Prx1/EMT signaling in OSCC metastasis.	Nicotine	66-74	peroxiredoxin 1	Mus musculus	94-98	
31118684-12	2019	Conclusion: The results indicate that nicotine promotes cervical lymph node metastasis through regulating Ets1/Prx1/EMT signaling during OSCC pathogenesis; consequently, Prx1 may represent a potential target for the prevention and treatment of OSCC.	Nicotine	38-46	peroxiredoxin 1	Mus musculus	111-115	
31118684-12	2019	Conclusion: The results indicate that nicotine promotes cervical lymph node metastasis through regulating Ets1/Prx1/EMT signaling during OSCC pathogenesis; consequently, Prx1 may represent a potential target for the prevention and treatment of OSCC.	Nicotine	38-46	peroxiredoxin 1	Mus musculus	170-174	
29088845-0	2017	Nicotine suppresses apoptosis by regulating alpha7nAChR/Prx1 axis in oral precancerous lesions.	Nicotine	0-8	peroxiredoxin 1	Mus musculus	56-60	
29088845-1	2017	Nicotine, a tumor promoter in tobacco, can increase Peroxiredoxin (Prx1) and nicotinic acetylcholine receptors (nAChRs) in oral squamous cell carcinoma (OSCC).	Nicotine	0-8	peroxiredoxin 1	Mus musculus	67-71	
29088845-4	2017	In DOK cells, Prx1 knockdown and blocking alpha7nAChR activated apoptosis, and nicotine increased the expression of Prx1, alpha3nAChR and alpha7nAChR, and inhibited MAPK activation.	Nicotine	79-87	peroxiredoxin 1	Mus musculus	116-120	
29088845-5	2017	Moreover, nicotine suppressed apoptosis depending on Prx1 and alpha7nAChR in DOK cells.	Nicotine	10-18	peroxiredoxin 1	Mus musculus	53-57	
29088845-7	2017	4NQO plus nicotine suppressed MAPK activation in Prx1 wild-type mice but not in Prx1 knockdown mice.	Nicotine	10-18	peroxiredoxin 1	Mus musculus	49-53	
29088845-8	2017	Our data demonstrate that nicotine inhibits cell apoptosis and promotes the growth of oral precancerous lesions via regulating alpha7nAChR/Prx1 during carcinogenesis of OSCC.	Nicotine	26-34	peroxiredoxin 1	Mus musculus	139-143	
34076143-8	2021	Nicotine upregulated CFL1 and downregulated PPP2R1A in 4-nitro-quinoline-1-oxide (4NQO)-induced OLK tissues in mice in part dependent on Prx1.	Nicotine	0-8	peroxiredoxin 1	Mus musculus	137-141	
31525533-8	2019	Our data showed that nicotine upregulated Trx, GTPBP4, DIRAS2, and downregulated ASK1 in 4NQO-induced OLK in mice, at least in part dependent on Prx1.	Nicotine	21-29	peroxiredoxin 1	Mus musculus	145-149