PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30439418-2	2019	Activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) by synthetic or endogenous agonists was shown to suppress nicotine-induced activation of mesolimbic dopamine system, one of the major neurobiological substrates of nicotine dependence, and nicotine-seeking behavior in rats and monkeys.	Nicotine	133-141	peroxisome proliferator activated receptor alpha	Rattus norvegicus	14-62	
20801430-3	2011	Here, we evaluated whether directly acting PPAR-alpha agonists can modulate reward-related effects of nicotine.	Nicotine	102-110	peroxisome proliferator activated receptor alpha	Rattus norvegicus	43-53	
20801430-5	2011	RESULTS: The PPAR-alpha agonists dose-dependently decreased nicotine self-administration and nicotine-induced reinstatement in rats and monkeys but did not alter food- or cocaine-reinforced operant behavior or the interoceptive effects of nicotine.	Nicotine	60-68	peroxisome proliferator activated receptor alpha	Rattus norvegicus	13-23	
20801430-5	2011	RESULTS: The PPAR-alpha agonists dose-dependently decreased nicotine self-administration and nicotine-induced reinstatement in rats and monkeys but did not alter food- or cocaine-reinforced operant behavior or the interoceptive effects of nicotine.	Nicotine	93-101	peroxisome proliferator activated receptor alpha	Rattus norvegicus	13-23	
20801430-5	2011	RESULTS: The PPAR-alpha agonists dose-dependently decreased nicotine self-administration and nicotine-induced reinstatement in rats and monkeys but did not alter food- or cocaine-reinforced operant behavior or the interoceptive effects of nicotine.	Nicotine	93-101	peroxisome proliferator activated receptor alpha	Rattus norvegicus	13-23	
20801430-6	2011	The PPAR-alpha agonists also dose-dependently decreased nicotine-induced excitation of dopamine neurons in the ventral tegmental area and nicotine-induced elevations of dopamine levels in the nucleus accumbens shell of rats.	Nicotine	56-64	peroxisome proliferator activated receptor alpha	Rattus norvegicus	4-14	
20801430-6	2011	The PPAR-alpha agonists also dose-dependently decreased nicotine-induced excitation of dopamine neurons in the ventral tegmental area and nicotine-induced elevations of dopamine levels in the nucleus accumbens shell of rats.	Nicotine	138-146	peroxisome proliferator activated receptor alpha	Rattus norvegicus	4-14	
20801430-7	2011	The ability of WY14643 and methOEA to counteract the behavioral, electrophysiological, and neurochemical effects of nicotine was reversed by the PPAR-alpha antagonist 1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-a,a-dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoic acid (MK886).	Nicotine	116-124	peroxisome proliferator activated receptor alpha	Rattus norvegicus	145-155	
30439418-2	2019	Activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) by synthetic or endogenous agonists was shown to suppress nicotine-induced activation of mesolimbic dopamine system, one of the major neurobiological substrates of nicotine dependence, and nicotine-seeking behavior in rats and monkeys.	Nicotine	133-141	peroxisome proliferator activated receptor alpha	Rattus norvegicus	64-73	
30439418-2	2019	Activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) by synthetic or endogenous agonists was shown to suppress nicotine-induced activation of mesolimbic dopamine system, one of the major neurobiological substrates of nicotine dependence, and nicotine-seeking behavior in rats and monkeys.	Nicotine	239-247	peroxisome proliferator activated receptor alpha	Rattus norvegicus	14-62	
30439418-2	2019	Activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) by synthetic or endogenous agonists was shown to suppress nicotine-induced activation of mesolimbic dopamine system, one of the major neurobiological substrates of nicotine dependence, and nicotine-seeking behavior in rats and monkeys.	Nicotine	239-247	peroxisome proliferator activated receptor alpha	Rattus norvegicus	64-73	
30439418-2	2019	Activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) by synthetic or endogenous agonists was shown to suppress nicotine-induced activation of mesolimbic dopamine system, one of the major neurobiological substrates of nicotine dependence, and nicotine-seeking behavior in rats and monkeys.	Nicotine	239-247	peroxisome proliferator activated receptor alpha	Rattus norvegicus	14-62	
30439418-2	2019	Activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) by synthetic or endogenous agonists was shown to suppress nicotine-induced activation of mesolimbic dopamine system, one of the major neurobiological substrates of nicotine dependence, and nicotine-seeking behavior in rats and monkeys.	Nicotine	239-247	peroxisome proliferator activated receptor alpha	Rattus norvegicus	64-73	
26864774-2	2016	FAAH inhibition has been recently identified as having a critical involvement in behaviors related to nicotine addiction and has been shown to reduce the effect of nicotine on the mesolimbic dopaminergic system via CB1R and peroxisome proliferator-activated receptor alpha (PPARalpha).	Nicotine	164-172	peroxisome proliferator activated receptor alpha	Rattus norvegicus	224-272	
26864774-2	2016	FAAH inhibition has been recently identified as having a critical involvement in behaviors related to nicotine addiction and has been shown to reduce the effect of nicotine on the mesolimbic dopaminergic system via CB1R and peroxisome proliferator-activated receptor alpha (PPARalpha).	Nicotine	164-172	peroxisome proliferator activated receptor alpha	Rattus norvegicus	274-283	
23554501-6	2013	Accordingly, in vivo production of endogenous PPARalpha ligands, triggered by alpha7-nAChR activation, blocks in rats nicotine-induced increased firing activity of dopamine neurons and displays antidepressant-like properties.	Nicotine	118-126	peroxisome proliferator activated receptor alpha	Rattus norvegicus	46-55