PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17003101-1 2007 We previously reported that nicotine promoted gastric cancer cell growth via upregulation of cyclooxygenase 2 (COX-2). Nicotine 28-36 prostaglandin-endoperoxide synthase 2 Homo sapiens 93-109 17369603-5 2007 beta-Adrenoceptors, cyclooxygenase-2 (COX-2), prostaglandin E(2) (PGE(2)), and vascular endothelial growth factor (VEGF) in tumor tissues were also increased by nicotine. Nicotine 161-169 prostaglandin-endoperoxide synthase 2 Homo sapiens 20-36 17369603-10 2007 Activation of beta-adrenoceptors and the subsequent stimulation of COX-2, PGE(2), and VEGF expression is perhaps an important mechanism in the tumorigenic action of nicotine on colon tumor growth. Nicotine 165-173 prostaglandin-endoperoxide synthase 2 Homo sapiens 67-72 17342254-0 2007 Lipopolysaccharide enhances the production of nicotine-induced prostaglandin E2 by an increase in cyclooxygenase-2 expression in osteoblasts. Nicotine 46-54 prostaglandin-endoperoxide synthase 2 Homo sapiens 98-114 17003101-1 2007 We previously reported that nicotine promoted gastric cancer cell growth via upregulation of cyclooxygenase 2 (COX-2). Nicotine 28-36 prostaglandin-endoperoxide synthase 2 Homo sapiens 111-116 17003101-6 2007 Inhibition of PKC by staurosporine attenuated nicotine-induced ERK1/2 phosphorylation and COX-2 expression. Nicotine 46-54 prostaglandin-endoperoxide synthase 2 Homo sapiens 90-95 17003101-7 2007 Furthermore, atenolol and ICI 118,551, a beta1- and beta2-adrenoceptor antagonist, respectively, reversed the stimulatory action of nicotine on the expression of PKC, ERK1/2 phosphorylation, and COX-2 together with cell proliferation. Nicotine 132-140 prostaglandin-endoperoxide synthase 2 Homo sapiens 195-200 17003101-8 2007 Collectively, these results suggest that nicotine stimulates gastric cancer cell growth through the activation of beta-adrenoceptors and the downstream PKC-betaI/ERK1/2/COX-2 pathway. Nicotine 41-49 prostaglandin-endoperoxide synthase 2 Homo sapiens 169-174 16539839-0 2006 Regulation of nicotine-induced cyclooxygenase-2 protein expression in human gingival fibroblasts. Nicotine 14-22 prostaglandin-endoperoxide synthase 2 Homo sapiens 31-47 16539839-1 2006 AIM: Activation of cyclooxygenase-2 (COX-2) expression by nicotine suggests a potential role for nicotine in the pathogenesis of smoking-associated periodontal disease. Nicotine 58-66 prostaglandin-endoperoxide synthase 2 Homo sapiens 19-35 16539839-1 2006 AIM: Activation of cyclooxygenase-2 (COX-2) expression by nicotine suggests a potential role for nicotine in the pathogenesis of smoking-associated periodontal disease. Nicotine 58-66 prostaglandin-endoperoxide synthase 2 Homo sapiens 37-42 16539839-1 2006 AIM: Activation of cyclooxygenase-2 (COX-2) expression by nicotine suggests a potential role for nicotine in the pathogenesis of smoking-associated periodontal disease. Nicotine 97-105 prostaglandin-endoperoxide synthase 2 Homo sapiens 19-35 16539839-1 2006 AIM: Activation of cyclooxygenase-2 (COX-2) expression by nicotine suggests a potential role for nicotine in the pathogenesis of smoking-associated periodontal disease. Nicotine 97-105 prostaglandin-endoperoxide synthase 2 Homo sapiens 37-42 16539839-2 2006 The aim of this study was to investigate whether chemical interactions can modulate nicotine-induced COX-2 expression in human gingival fibroblasts (HGF). Nicotine 84-92 prostaglandin-endoperoxide synthase 2 Homo sapiens 101-106 16539839-6 2006 Treatment of HGF with nicotine was shown to mediate COX-2 protein expression. Nicotine 22-30 prostaglandin-endoperoxide synthase 2 Homo sapiens 52-57 16539839-7 2006 Pretreatment with OTZ decreased nicotine-induced COX-2 protein level by approximately 60 % (P<0.05). Nicotine 32-40 prostaglandin-endoperoxide synthase 2 Homo sapiens 49-54 16539839-8 2006 However, BSO enhanced nicotine-induced COX-2 protein level up to approximately 3-fold (P<0.05). Nicotine 22-30 prostaglandin-endoperoxide synthase 2 Homo sapiens 39-44 16539839-9 2006 Treatment of HGF with PD98059 decreased nicotine-induced COX-2 protein expression. Nicotine 40-48 prostaglandin-endoperoxide synthase 2 Homo sapiens 57-62 16539839-11 2006 CONCLUSION: Nicotine may play a significant role in the pathogenesis of cigarette smoking associated-periodontitis via the activation of COX-2 which is augmented by oxidative stress and mediated by extracellular signal-regulated protein kinase signaling. Nicotine 12-20 prostaglandin-endoperoxide synthase 2 Homo sapiens 137-142 27681882-14 2016 Importantly, nicotine"s inhibitory effect on IL-6 production was reversed with the specific COX-2 inhibitor NS-398. Nicotine 13-21 prostaglandin-endoperoxide synthase 2 Homo sapiens 92-97 16317086-0 2005 Nicotine induces cyclooxygenase-2 and vascular endothelial growth factor receptor-2 in association with tumor-associated invasion and angiogenesis in gastric cancer. Nicotine 0-8 prostaglandin-endoperoxide synthase 2 Homo sapiens 17-83 16317086-3 2005 Cyclooxygenase-2 (COX-2) plays an important role in the promoting action of nicotine on gastric cancer growth. Nicotine 76-84 prostaglandin-endoperoxide synthase 2 Homo sapiens 0-16 16317086-3 2005 Cyclooxygenase-2 (COX-2) plays an important role in the promoting action of nicotine on gastric cancer growth. Nicotine 76-84 prostaglandin-endoperoxide synthase 2 Homo sapiens 18-23 16317086-6 2005 Nicotine (200 microg/mL) stimulated gastric cancer cell proliferation, which was blocked by SC-236 (a highly selective COX-2 inhibitor) and CBO-P11 (a VEGFR inhibitor). Nicotine 0-8 prostaglandin-endoperoxide synthase 2 Homo sapiens 119-124 16317086-11 2005 The activity of matrix metalloproteinases 2 and 9 and protein expressions of plasminogen activators (urokinase-type plasminogen activator and its receptor), which are the indicators of invasion and migration processes, were increased by nicotine but blocked by COX-2 and VEGFR inhibitors. Nicotine 237-245 prostaglandin-endoperoxide synthase 2 Homo sapiens 261-266 16317086-12 2005 Taken together, our results reveal that the promoting action of nicotine on angiogenesis, tumor invasion, and metastasis is COX-2/VEGF/VEGFR dependent. Nicotine 64-72 prostaglandin-endoperoxide synthase 2 Homo sapiens 124-129 16054976-6 2005 Nicotine may promote carcinogenesis through activation of extracellular signal-regulated kinase/cyclooxygenase-2/vascular endothelial growth factor signaling pathway. Nicotine 0-8 prostaglandin-endoperoxide synthase 2 Homo sapiens 96-112 16054988-5 2005 Study results, with the use of animal xenograft models and cell culture systems, show that nicotine stimulates the progression of tumor growth, through a cyclooxygenase-2-dependent pathway. Nicotine 91-99 prostaglandin-endoperoxide synthase 2 Homo sapiens 154-170 12941074-0 2003 Induction of cyclooxygenase-2 mRNA and protein expression in human gingival fibroblasts stimulated with nicotine. Nicotine 104-112 prostaglandin-endoperoxide synthase 2 Homo sapiens 13-29 12941074-4 2003 OBJECTIVES: The aim of the present study was to investigate the effects of nicotine on the expression of cyclooxygenase-2 (COX-2) mRNA gene and protein in cultured human gingival fibroblasts (HGFs). Nicotine 75-83 prostaglandin-endoperoxide synthase 2 Homo sapiens 105-121 12941074-4 2003 OBJECTIVES: The aim of the present study was to investigate the effects of nicotine on the expression of cyclooxygenase-2 (COX-2) mRNA gene and protein in cultured human gingival fibroblasts (HGFs). Nicotine 75-83 prostaglandin-endoperoxide synthase 2 Homo sapiens 123-128 12941074-5 2003 Furthermore, to elucidate whether induction of COX-2 may be associated with nicotine- induced cytotoxicity, NS-398 (a selective COX-2 inhibitor), was added to test its protective effect. Nicotine 76-84 prostaglandin-endoperoxide synthase 2 Homo sapiens 47-52 12941074-8 2003 RESULTS: The exposure of quiescent human HGFs to nicotine resulted in the induction of COX-2 mRNA expression. Nicotine 49-57 prostaglandin-endoperoxide synthase 2 Homo sapiens 87-92 12941074-9 2003 The levels of the COX-2 mRNAs increased about 1.5 and 2.5 fold after exposure to 2.5 and 15 mm nicotine for 2 h (P < 0.05), respectively. Nicotine 95-103 prostaglandin-endoperoxide synthase 2 Homo sapiens 18-23 12941074-10 2003 Moreover, the peak of COX-2 mRNA levels induced by nicotine was 10 mm at 2 h incubation period. Nicotine 51-59 prostaglandin-endoperoxide synthase 2 Homo sapiens 22-27 12941074-11 2003 Investigations of the time dependence of COX-2 mRNA expression in nicotine-treated HGFs revealed a rapid accumulation of the transcript, a signal first detectable at 30 min and diminished to control level after 8 h. In addition, 10 mm nicotine also induced COX-2 protein expression in HGFs. Nicotine 66-74 prostaglandin-endoperoxide synthase 2 Homo sapiens 41-46 12941074-11 2003 Investigations of the time dependence of COX-2 mRNA expression in nicotine-treated HGFs revealed a rapid accumulation of the transcript, a signal first detectable at 30 min and diminished to control level after 8 h. In addition, 10 mm nicotine also induced COX-2 protein expression in HGFs. Nicotine 66-74 prostaglandin-endoperoxide synthase 2 Homo sapiens 257-262 12941074-11 2003 Investigations of the time dependence of COX-2 mRNA expression in nicotine-treated HGFs revealed a rapid accumulation of the transcript, a signal first detectable at 30 min and diminished to control level after 8 h. In addition, 10 mm nicotine also induced COX-2 protein expression in HGFs. Nicotine 235-243 prostaglandin-endoperoxide synthase 2 Homo sapiens 41-46 12941074-11 2003 Investigations of the time dependence of COX-2 mRNA expression in nicotine-treated HGFs revealed a rapid accumulation of the transcript, a signal first detectable at 30 min and diminished to control level after 8 h. In addition, 10 mm nicotine also induced COX-2 protein expression in HGFs. Nicotine 235-243 prostaglandin-endoperoxide synthase 2 Homo sapiens 257-262 12941074-13 2003 CONCLUSIONS: Taken together, the activation of COX-2 expression by nicotine suggests a potential role for nicotine in the pathogenesis of smoking-associated periodontal disease. Nicotine 67-75 prostaglandin-endoperoxide synthase 2 Homo sapiens 47-52 12941074-13 2003 CONCLUSIONS: Taken together, the activation of COX-2 expression by nicotine suggests a potential role for nicotine in the pathogenesis of smoking-associated periodontal disease. Nicotine 106-114 prostaglandin-endoperoxide synthase 2 Homo sapiens 47-52 28901402-7 2017 CORM-3 attenuated the LPS- and nicotine-induced production of PGE2, COX-2 and RANKL in human PDLCs by releasing CO, and upregulated the expression of OPG. Nicotine 31-39 prostaglandin-endoperoxide synthase 2 Homo sapiens 68-73 26100595-0 2015 Nicotine-induced cellular stresses and autophagy in human cancer colon cells: A supportive effect on cell homeostasis via up-regulation of Cox-2 and PGE(2) production. Nicotine 0-8 prostaglandin-endoperoxide synthase 2 Homo sapiens 139-144 26334245-9 2015 Pharmacologic and siRNA-mediated inhibition of PLD1 and PLD2 attenuated the nicotine- and LPS-induced upregulation of inducible nitric oxide (NO) synthase and cyclooxygenase-2, production of NO, and prostaglandin E2, and mRNA expression and secretion of tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-8. Nicotine 76-84 prostaglandin-endoperoxide synthase 2 Homo sapiens 159-175 26617606-8 2015 This article presents our perspective on the modulatory effects of CS and nicotine on the "histamine-TLR-COX-2 axis." Nicotine 74-82 prostaglandin-endoperoxide synthase 2 Homo sapiens 105-110 26100595-6 2015 Additionally, we have shown that nicotine induces a PI3-K dependent up-regulation of cyclooxygenase-2 (Cox-2) expression and prostaglandin E2 (PGE2) production. Nicotine 33-41 prostaglandin-endoperoxide synthase 2 Homo sapiens 85-101 26100595-6 2015 Additionally, we have shown that nicotine induces a PI3-K dependent up-regulation of cyclooxygenase-2 (Cox-2) expression and prostaglandin E2 (PGE2) production. Nicotine 33-41 prostaglandin-endoperoxide synthase 2 Homo sapiens 103-108 22571166-2 2012 The aim of this study was to explore the effects, as well as the signaling pathway, of nicotine and lipopolysaccharide (LPS) on the expression of HIF-1alpha and on the production of its target genes, including cyclooxygenase-2 (COX-2)-derived prostaglandin E(2) (PGE(2) ), MMP-2 and MMP-9 in PDLCs. Nicotine 87-95 prostaglandin-endoperoxide synthase 2 Homo sapiens 210-226 22571166-5 2012 RESULTS: LPS and nicotine synergistically induced the production of PGE(2) , MMP-2 and MMP-9, and increased the expression of MMP-2, MMP-9, COX-2 and HIF-1alpha proteins. Nicotine 19-27 prostaglandin-endoperoxide synthase 2 Homo sapiens 142-147 22571166-6 2012 Inhibition of HIF-1alpha activity by chetomin or knockdown of HIF1alpha gene expression by small interfering RNA markedly attenuated the production of LPS- and nicotine-stimulated PGE(2) and MMPs, as well as the expression of COX-2 and HIF-1alpha. Nicotine 160-168 prostaglandin-endoperoxide synthase 2 Homo sapiens 226-231 22571166-7 2012 Furthermore, pretreatment with inhibitors of COX-2, p38, extracellular signal-regulated kinase, Jun N-terminal kinase, protein kinase C, phosphatidylinositol 3-kinase and nuclear factor-kappaB decreased the expression of nicotine- and LPS-induced HIF-1alpha and COX-2, as well as the activity of PGE(2) and MMPs. Nicotine 221-229 prostaglandin-endoperoxide synthase 2 Homo sapiens 45-50 22571166-7 2012 Furthermore, pretreatment with inhibitors of COX-2, p38, extracellular signal-regulated kinase, Jun N-terminal kinase, protein kinase C, phosphatidylinositol 3-kinase and nuclear factor-kappaB decreased the expression of nicotine- and LPS-induced HIF-1alpha and COX-2, as well as the activity of PGE(2) and MMPs. Nicotine 221-229 prostaglandin-endoperoxide synthase 2 Homo sapiens 262-267 22571166-2 2012 The aim of this study was to explore the effects, as well as the signaling pathway, of nicotine and lipopolysaccharide (LPS) on the expression of HIF-1alpha and on the production of its target genes, including cyclooxygenase-2 (COX-2)-derived prostaglandin E(2) (PGE(2) ), MMP-2 and MMP-9 in PDLCs. Nicotine 87-95 prostaglandin-endoperoxide synthase 2 Homo sapiens 228-233 21081469-9 2011 Furthermore, activation of COX-2/prostaglandin E2 (PGE2) signaling in response to nicotine was mediated by the action of prostaglandin E receptors (EP2 and EP4). Nicotine 82-90 prostaglandin-endoperoxide synthase 2 Homo sapiens 27-32 20079464-0 2010 Nicotine induces cyclooxygenase-2 and prostaglandin E(2) expression in human umbilical vein endothelial cells. Nicotine 0-8 prostaglandin-endoperoxide synthase 2 Homo sapiens 17-33 20079464-3 2010 Nicotine treatment increased the expressions of COX-2 at mRNA and protein level in a dose-dependent manner, following prostaglandin E(2) (PGE(2)) release enhancement. Nicotine 0-8 prostaglandin-endoperoxide synthase 2 Homo sapiens 48-53 20079464-4 2010 Pyrrolidine dithiocarbamate (PDTC, NF-kappaB inhibitor) and alpha-Bungarotoxin (alpha-Btx, nicotinic acetylcholine receptor antagonist) attenuated the nicotine-induced COX-2 expression and PGE(2) production. Nicotine 151-159 prostaglandin-endoperoxide synthase 2 Homo sapiens 168-173 20079464-5 2010 Furthermore, nicotine-induced ICAM-1 expression was reduced by NS-398 (selective COX-2 inhibitor). Nicotine 13-21 prostaglandin-endoperoxide synthase 2 Homo sapiens 81-86 20079464-6 2010 Taken together, the present study demonstrated that nicotine-induced COX-2 expression through NF-kappaB activation which mediated by nicotinic acetylcholine receptor and the induction of COX-2 was related to ICAM-1 expression. Nicotine 52-60 prostaglandin-endoperoxide synthase 2 Homo sapiens 69-74 20079464-6 2010 Taken together, the present study demonstrated that nicotine-induced COX-2 expression through NF-kappaB activation which mediated by nicotinic acetylcholine receptor and the induction of COX-2 was related to ICAM-1 expression. Nicotine 52-60 prostaglandin-endoperoxide synthase 2 Homo sapiens 187-192 19955489-7 2010 Nicotine induced the expression of cyclooxygenase-2, prostaglandin E(2) (PGE(2)), and cAMP in the presence and absence of AGE-2 and AGE-3. Nicotine 0-8 prostaglandin-endoperoxide synthase 2 Homo sapiens 35-51 20470258-0 2010 Heme oxygenase-1 mediates nicotine- and lipopolysaccharide-induced expression of cyclooxygenase-2 and inducible nitric oxide synthase in human periodontal ligament cells. Nicotine 26-34 prostaglandin-endoperoxide synthase 2 Homo sapiens 81-133 20470258-5 2010 RESULTS: Lipopolysaccharide and nicotine synergistically induced the production of NO and PGE(2) and increased the protein expression of iNOS, COX-2 and HO-1. Nicotine 32-40 prostaglandin-endoperoxide synthase 2 Homo sapiens 143-148 19729077-6 2009 Apigenin significantly inhibited the nicotine- and LPS-induced production of NO, PGE2, IL-1beta, TNF-alpha, IL-6, and IL-12, and the upregulation of iNOS and COX-2 in hPDL cells. Nicotine 37-45 prostaglandin-endoperoxide synthase 2 Homo sapiens 158-163 19892012-10 2010 In addition, treatment with nicotine could induce COX-2, PGE(2), and IL-6 generation in in vivo and in vitro studies. Nicotine 28-36 prostaglandin-endoperoxide synthase 2 Homo sapiens 50-55 19729077-3 2009 MATERIALS AND METHODS: Western blotting was used to examine the effect of apigenin (10-40 microM) on the LPS- and nicotine-induced expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and heme oxygenase-1 (HO-1), as well as the phosphorylation of mitogen-activated protein kinases (MAPKs), in hPDL cells. Nicotine 114-122 prostaglandin-endoperoxide synthase 2 Homo sapiens 145-161 19729077-3 2009 MATERIALS AND METHODS: Western blotting was used to examine the effect of apigenin (10-40 microM) on the LPS- and nicotine-induced expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and heme oxygenase-1 (HO-1), as well as the phosphorylation of mitogen-activated protein kinases (MAPKs), in hPDL cells. Nicotine 114-122 prostaglandin-endoperoxide synthase 2 Homo sapiens 163-168 19147120-0 2009 Nicotine stimulates the expression of cyclooxygenase-2 mRNA via NFkappaB activation in human gingival fibroblasts. Nicotine 0-8 prostaglandin-endoperoxide synthase 2 Homo sapiens 38-54 19147120-2 2009 We investigated the involvement of the transcription nuclear factor kappa B (NFkappaB) in the nicotine-induced expression of cyclooxygenase-2 (COX-2), a key enzyme for prostaglandin synthesis, in human gingival fibroblasts. Nicotine 94-102 prostaglandin-endoperoxide synthase 2 Homo sapiens 125-141 19147120-2 2009 We investigated the involvement of the transcription nuclear factor kappa B (NFkappaB) in the nicotine-induced expression of cyclooxygenase-2 (COX-2), a key enzyme for prostaglandin synthesis, in human gingival fibroblasts. Nicotine 94-102 prostaglandin-endoperoxide synthase 2 Homo sapiens 143-148 19147120-3 2009 Nicotine-stimulated release of prostaglandin E(2) and expression of COX-2 mRNA in a time- and dose-dependent manner. Nicotine 0-8 prostaglandin-endoperoxide synthase 2 Homo sapiens 68-73 19147120-4 2009 The nicotine-stimulated release of prostaglandin E(2) and expression of COX-2 mRNA and protein were inhibited by an NFkappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), by approximately 50%. Nicotine 4-12 prostaglandin-endoperoxide synthase 2 Homo sapiens 72-77 19147120-8 2009 These results suggest that nicotine is taken up by human gingival fibroblasts and that it then stimulates COX-2 expression via the activation of NFkappaB and the subsequent release of prostaglandin E(2). Nicotine 27-35 prostaglandin-endoperoxide synthase 2 Homo sapiens 106-111 18805435-0 2008 Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induce cyclooxygenase-2 activity in human gastric cancer cells: Involvement of nicotinic acetylcholine receptor (nAChR) and beta-adrenergic receptor signaling pathways. Nicotine 0-8 prostaglandin-endoperoxide synthase 2 Homo sapiens 67-83 18805435-7 2008 In addition, nicotine and NNK mediated COX-2 induction via different receptors to modulate several G1/S transition regulatory proteins and promote gastric cancer cell growth. Nicotine 13-21 prostaglandin-endoperoxide synthase 2 Homo sapiens 39-44 18805435-8 2008 Selective COX-2 inhibitor (SC-236) caused G1 arrest and abrogated nicotine/NNK-induced cell proliferation. Nicotine 66-74 prostaglandin-endoperoxide synthase 2 Homo sapiens 10-15