PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10651151-5	2000	Nociceptin 0.1 micromol/kg reduced the nicotine-induced vasopressor response by about 40% but at doses up to 1 micromol/kg failed to affect the increase in blood pressure evoked by noradrenaline.	Nicotine	39-47	prepronociceptin	Rattus norvegicus	0-10	
10651151-6	2000	The inhibitory action of nociceptin on the electrically and nicotine-induced increase in blood pressure was attenuated by the ORL1 receptor antagonists naloxone benzoylhydrazone (5 micromol/kg) and/or [Phe1psi(CH2-NH)Gly2]-nociceptin(1-13)NH2 (1 micromol/kg) but was not affected by naloxone 10 micromol/kg.	Nicotine	60-68	prepronociceptin	Rattus norvegicus	25-35	
10651151-6	2000	The inhibitory action of nociceptin on the electrically and nicotine-induced increase in blood pressure was attenuated by the ORL1 receptor antagonists naloxone benzoylhydrazone (5 micromol/kg) and/or [Phe1psi(CH2-NH)Gly2]-nociceptin(1-13)NH2 (1 micromol/kg) but was not affected by naloxone 10 micromol/kg.	Nicotine	60-68	prepronociceptin	Rattus norvegicus	223-233	
34854073-0	2022	Genetic Deletion or Pharmacological Blockade of Nociceptin/Orphanin FQ Receptors in the Ventral Tegmental Area Attenuates Nicotine-Motivated Behaviour.	Nicotine	122-130	prepronociceptin	Rattus norvegicus	48-58	
34854073-0	2022	Genetic Deletion or Pharmacological Blockade of Nociceptin/Orphanin FQ Receptors in the Ventral Tegmental Area Attenuates Nicotine-Motivated Behaviour.	Nicotine	122-130	prepronociceptin	Rattus norvegicus	59-70	
27430399-0	2016	Repeated nicotine exposure modulates prodynorphin and pronociceptin levels in the reward pathway.	Nicotine	9-17	prepronociceptin	Rattus norvegicus	54-67	
27430399-9	2016	Pnoc mRNA was significantly increased in the VM and the PFCx after sub-chronic administration of nicotine, whereas no alterations were observed after acute treatment.	Nicotine	97-105	prepronociceptin	Rattus norvegicus	0-4	
27430399-12	2016	While several pnoc and pdyn changes were associated to nicotine administration, the only significant effect of sensitization was a significant increase in pdyn in the CPu.	Nicotine	55-63	prepronociceptin	Rattus norvegicus	14-18