PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34771509-8 2021 In summary, this study demonstrated that the well-known nicotine derivative-activated nAChRalpha7 could induce STAT3/NRF2 pathways and subsequently promote PD-L1 expression in normal lung epithelial cells. Nicotine 56-64 signal transducer and activator of transcription 3 Homo sapiens 111-116 19741199-5 2009 Treatment of macrovascular human umbilical vein endothelial cells (HUVECs) and microvascular endothelial cells (MVECs) with the cholinergic agonists nicotine and GTS-21 significantly reduced IL-6-mediated monocyte chemoattractant protein-1 (MCP-1) production and ICAM-1 expression which are regulated through the JAK2/STAT3 pathway. Nicotine 149-157 signal transducer and activator of transcription 3 Homo sapiens 318-323 20106947-0 2010 Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder cancer cells. Nicotine 10-18 signal transducer and activator of transcription 3 Homo sapiens 81-86 20106947-4 2010 The objective of this study was to identify the role of Stat3 in chemoresistance induced by nicotine in human bladder cancer cell line, T24 cells. Nicotine 92-100 signal transducer and activator of transcription 3 Homo sapiens 56-61 20106947-8 2010 We provide evidence for the first time that nicotine strongly activated Stat3, leading to Cyclin D1 overexpression, cell cycle perturbations, and chemoresistance. Nicotine 44-52 signal transducer and activator of transcription 3 Homo sapiens 72-77 20106947-9 2010 Furthermore, nicotine mobilized Stat3 signaling, resulting in the loss of extracellular signal-regulated protein kinase 1/2 (ERK 1/2) activation and reduced chemosensitivity via nicotinic acetylcholine receptors and beta-adrenoceptors. Nicotine 13-21 signal transducer and activator of transcription 3 Homo sapiens 32-37 18448488-0 2008 Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells. Nicotine 40-48 signal transducer and activator of transcription 3 Homo sapiens 20-25 18448488-6 2008 We found that nicotine simultaneously activates Stat3 and extracellular signal regulated kinase 1/2 (ERK1/2) in T24 cells. Nicotine 14-22 signal transducer and activator of transcription 3 Homo sapiens 48-53 18448488-9 2008 We conclude that through nAChR and beta-adrenoceptors, nicotine activates ERK1/2 and Stat3 signaling pathways, leading to Cyclin D1 expression and cell proliferation. Nicotine 55-63 signal transducer and activator of transcription 3 Homo sapiens 85-90 34647621-0 2022 Nicotine causes alternative polarization of macrophages via Src-mediated STAT3 activation: Potential pathobiological implications. Nicotine 0-8 signal transducer and activator of transcription 3 Homo sapiens 73-78 34647621-8 2022 Mechanistic studies revealed increased phosphorylation of STAT3 in nicotine-treated macrophages that was mediated through Src activation. Nicotine 67-75 signal transducer and activator of transcription 3 Homo sapiens 58-63 34647621-9 2022 Importantly, pretreatment of macrophages with either Src or STAT3 inhibitor abrogated nicotine-induced macrophage polarization, growth, and motility, suggesting a functional role of the Src-STAT3 signaling axis. Nicotine 86-94 signal transducer and activator of transcription 3 Homo sapiens 190-195 34302119-0 2021 Correction: Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling. Nicotine 68-76 signal transducer and activator of transcription 3 Homo sapiens 137-142 31956373-0 2020 Nicotine Upregulates the Level of Mcl-1 through STAT3 in H1299 Cells. Nicotine 0-8 signal transducer and activator of transcription 3 Homo sapiens 48-53 32976884-9 2020 It positively regulated nicotine, NNK, NNN, and BaP induced proliferation, survival and migration of lung cancer cells possibly via Akt/STAT-3 signaling. Nicotine 24-32 signal transducer and activator of transcription 3 Homo sapiens 136-142 31953160-0 2020 Nicotine promotes activation of human pancreatic stellate cells through inducing autophagy via alpha7nAChR-mediated JAK2/STAT3 signaling pathway. Nicotine 0-8 signal transducer and activator of transcription 3 Homo sapiens 121-126 31953160-10 2020 Moreover, the alpha7nAChR-mediated JAK2/STAT3 signaling pathway was activated by nicotine, this pathway and effects of nicotine can be blocked by alpha-BTX. Nicotine 81-89 signal transducer and activator of transcription 3 Homo sapiens 40-45 31953160-10 2020 Moreover, the alpha7nAChR-mediated JAK2/STAT3 signaling pathway was activated by nicotine, this pathway and effects of nicotine can be blocked by alpha-BTX. Nicotine 119-127 signal transducer and activator of transcription 3 Homo sapiens 40-45 31953160-11 2020 SIGNIFICANCE: Our finding suggests that nicotine can promote activation of human pancreatic stellate cells (hPSCs) through inducing autophagy via alpha7nAChR-mediated JAK2/STAT3 signaling pathway, providing a new insight into the mechanisms by which nicotine affects pancreatic fibrosis. Nicotine 40-48 signal transducer and activator of transcription 3 Homo sapiens 172-177 35461327-7 2022 We also found that chronic nicotine exposure recruited STAT3-activated N2-neutrophils within the brain pre-metastatic niche and secreted exosomal miR-4466 which promoted stemness and metabolic switching via SKI/SOX2/CPT1A axis in the tumor cells in the brain thereby enabling metastasis. Nicotine 27-35 signal transducer and activator of transcription 3 Homo sapiens 55-60 35461327-10 2022 We also demonstrated that inhibiting nicotine-induced STAT3-mediated neutrophil polarization effectively abrogated brain metastasis in vivo. Nicotine 37-45 signal transducer and activator of transcription 3 Homo sapiens 54-59 33603170-0 2021 Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling. Nicotine 56-64 signal transducer and activator of transcription 3 Homo sapiens 125-130 33603170-3 2021 Here we report that nicotine enhances ESCC cancer malignancy and tumor-initiating capacity by interacting with cholinergic receptor nicotinic alpha 7 subunit (CHRNA7) and subsequently activating the JAK2/STAT3 signaling pathway. Nicotine 20-28 signal transducer and activator of transcription 3 Homo sapiens 204-209 31956373-3 2020 Therefore, we examined the STAT3 cascade in nicotine regulation of Mcl-1 transcription in human lung cancer cells. Nicotine 44-52 signal transducer and activator of transcription 3 Homo sapiens 27-32 31956373-4 2020 Methods: The effects of nicotine on the expression of STAT3 and Mcl-1 were determined using western blot. Nicotine 24-32 signal transducer and activator of transcription 3 Homo sapiens 54-59 31956373-7 2020 Results: STAT3 was constitutively activated (i.e., tyrosine-phosphorylated, serine-phosphorylated and nuclear translocation), meanwhile the expression and transcriptional activity of Mcl-1 were up-regulated in lung cancer cells following treatment with nicotine. Nicotine 253-261 signal transducer and activator of transcription 3 Homo sapiens 9-14 31956373-9 2020 Deleted mutagenesis of a putative STAT3 consensus binding sequence decreased Mcl-1 promoter activity and eliminated the increase of Mcl-1 promoter activity induced by nicotine. Nicotine 167-175 signal transducer and activator of transcription 3 Homo sapiens 34-39 31956373-12 2020 Conclusions: We have demonstrated that nicotine induces up-regulation of Mcl-1 through STAT3, which process may be independent on JAKs and not only dependent on the phosphorylation of Y705. Nicotine 39-47 signal transducer and activator of transcription 3 Homo sapiens 87-92 25295465-8 2014 Interestingly, renalase promoter activity was augmented by nicotine and catecholamines; while Sp1 and STAT3 synergistically activated the nicotine-induced effect, Sp1 appeared to enhance epinephrine-evoked renalase transcription. Nicotine 138-146 signal transducer and activator of transcription 3 Homo sapiens 102-107 28766689-5 2017 Here, we demonstrated that nicotine exerts its anti-inflammatory effect by TIPE2 upregulation and phosphorylated stat3 mediated the inhibition of NF-kappaB activation, which was supported by the following evidence: firstly, both nicotine and TIPE2 inhibit pro-inflammatory cytokine release via NF-kappaB inactivation. Nicotine 27-35 signal transducer and activator of transcription 3 Homo sapiens 113-118 31835799-9 2019 Moreover, PD-L1 expression was upregulated in melanoma cells after nicotine treatment via the transcription factor STAT3 binding to the PD-L1 promoter. Nicotine 67-75 signal transducer and activator of transcription 3 Homo sapiens 115-120 30317657-0 2019 Nicotine stimulates IL-6 expression by activating the AP-1 and STAT-3 pathways in human endothelial EA.hy926 cells. Nicotine 0-8 signal transducer and activator of transcription 3 Homo sapiens 63-69 30317657-5 2019 Furthermore, the antioxidant compound N-acetyl-cysteine eliminated the nicotine-activated production of reactive oxygen species (ROS) and inhibited signal transducer and activator of transcription 3 (STAT-3) phosphorylation; these two mechanisms mediated the upregulation of IL-6 expression by nicotine. Nicotine 294-302 signal transducer and activator of transcription 3 Homo sapiens 200-206 30317657-7 2019 Our data demonstrate that nicotine induced IL-6 expression, which, in turn, enhanced the invasiveness of endothelial EA.hy926 cells, via activation of the p38 MAPK/AP-1 and ROS/STAT-3 signaling pathways. Nicotine 26-34 signal transducer and activator of transcription 3 Homo sapiens 177-183 28766689-5 2017 Here, we demonstrated that nicotine exerts its anti-inflammatory effect by TIPE2 upregulation and phosphorylated stat3 mediated the inhibition of NF-kappaB activation, which was supported by the following evidence: firstly, both nicotine and TIPE2 inhibit pro-inflammatory cytokine release via NF-kappaB inactivation. Nicotine 229-237 signal transducer and activator of transcription 3 Homo sapiens 113-118 28766689-7 2017 Moreover, the enhancement of stat3 phosphorylation and decrease of LPS-induced p65 translocation were achieved by nicotine treatment. Nicotine 114-122 signal transducer and activator of transcription 3 Homo sapiens 29-34 28766689-8 2017 Importantly, nicotine treatment augments the interaction of phosphorylated stat3 and p65, indicating that the inhibitory effect of nicotine on NF-kappaB activation was mediated with protein-protein interactions. Nicotine 13-21 signal transducer and activator of transcription 3 Homo sapiens 75-80 28766689-8 2017 Importantly, nicotine treatment augments the interaction of phosphorylated stat3 and p65, indicating that the inhibitory effect of nicotine on NF-kappaB activation was mediated with protein-protein interactions. Nicotine 131-139 signal transducer and activator of transcription 3 Homo sapiens 75-80 28766689-9 2017 Hence, this study revealed that TIPE2 upregulation and stat3 phosphorylation contribute to nicotine-mediated anti-inflammation effect, indicating that TIPE2 and stat3 might be potential molecules for dealing with inflammation-associated diseases. Nicotine 91-99 signal transducer and activator of transcription 3 Homo sapiens 55-60 28766689-9 2017 Hence, this study revealed that TIPE2 upregulation and stat3 phosphorylation contribute to nicotine-mediated anti-inflammation effect, indicating that TIPE2 and stat3 might be potential molecules for dealing with inflammation-associated diseases. Nicotine 91-99 signal transducer and activator of transcription 3 Homo sapiens 161-166 28750889-0 2017 Reciprocal activation of alpha5-nAChR and STAT3 in nicotine-induced human lung cancer cell proliferation. Nicotine 51-59 signal transducer and activator of transcription 3 Homo sapiens 42-47 28750889-6 2017 Nicotine increased the levels of alpha5-nAChR mRNA and protein in NSCLC cell lines and activated the JAK2/STAT3 signaling cascade. Nicotine 0-8 signal transducer and activator of transcription 3 Homo sapiens 106-111 28750889-7 2017 Nicotine-induced activation of JAK2/STAT3 signaling was inhibited by the silencing of alpha5-nAChR. Nicotine 0-8 signal transducer and activator of transcription 3 Homo sapiens 36-41 28750889-10 2017 By silencing STAT3 expression, nicotine-induced upregulation of alpha5-nAChR was suppressed. Nicotine 31-39 signal transducer and activator of transcription 3 Homo sapiens 13-18 28750889-11 2017 Downregulation of alpha5-nAChR and/or STAT3 expression inhibited nicotine-induced lung cancer cell proliferation. Nicotine 65-73 signal transducer and activator of transcription 3 Homo sapiens 38-43 28750889-12 2017 These results suggest that there is a feedback loop between alpha5-nAChR and STAT3 that contributes to the nicotine-induced tumor cell proliferation, which indicates that alpha5-nAChR is an important therapeutic target involved in tobacco-associated lung carcinogenesis. Nicotine 107-115 signal transducer and activator of transcription 3 Homo sapiens 77-82 27709266-0 2017 Nicotine protects against DSS colitis through regulating microRNA-124 and STAT3. Nicotine 0-8 signal transducer and activator of transcription 3 Homo sapiens 74-79 27709266-6 2017 Further analysis indicated that nicotine inhibited STAT3 activation in vivo and in IL-6 treated Caco-2 cells and Jurkat human T lymphocytes, in which miR-124 knockdown led to increased activation of STAT3. Nicotine 32-40 signal transducer and activator of transcription 3 Homo sapiens 51-56 27709266-6 2017 Further analysis indicated that nicotine inhibited STAT3 activation in vivo and in IL-6 treated Caco-2 cells and Jurkat human T lymphocytes, in which miR-124 knockdown led to increased activation of STAT3. Nicotine 32-40 signal transducer and activator of transcription 3 Homo sapiens 199-204 27709266-7 2017 Blocking STAT3 activity alone is beneficial for DSS colitis and also abolished nicotine"s protective effect in this model. Nicotine 79-87 signal transducer and activator of transcription 3 Homo sapiens 9-14 27709266-8 2017 These data indicate that nicotine exerts its protective action in UC through inducing miR-124 and inhibiting STAT3, and suggest that the miR-124/STAT3 system is a potential target for the therapeutic intervention of UC. Nicotine 25-33 signal transducer and activator of transcription 3 Homo sapiens 109-114 27709266-8 2017 These data indicate that nicotine exerts its protective action in UC through inducing miR-124 and inhibiting STAT3, and suggest that the miR-124/STAT3 system is a potential target for the therapeutic intervention of UC. Nicotine 25-33 signal transducer and activator of transcription 3 Homo sapiens 145-150 27709266-12 2017 MiR-124 mediates the inhibitory role of nicotine on STAT3/p-STAT3. Nicotine 40-48 signal transducer and activator of transcription 3 Homo sapiens 52-57 27709266-12 2017 MiR-124 mediates the inhibitory role of nicotine on STAT3/p-STAT3. Nicotine 40-48 signal transducer and activator of transcription 3 Homo sapiens 60-65 25565665-7 2015 HIF-2alpha inhibitor and HIF-2alpha siRNA inhibited the effects of nicotine and LPS on the activation of Akt, JAK2 and STAT3, ERK and JNK MAPK, nuclear factor-kappaB, c-Jun, and c-Fos. Nicotine 67-75 signal transducer and activator of transcription 3 Homo sapiens 119-124 25259522-2 2014 A signaling pathway downstream from the alpha7 nAChRs, which involves the collaboration of JAK2/STAT3 and NF-kappaB to interfere with signaling by Toll-like receptors (TLRs), has been implicated in this anti-inflammatory effect of nicotine. Nicotine 231-239 signal transducer and activator of transcription 3 Homo sapiens 96-101 25259522-5 2014 By using selective inhibitors of different signaling molecules downstream from the receptor, we provide evidence that activation of STAT3, via either JAK2 and/or PI3K, through a single (JAK2/PI3K/STAT3) or two convergent cascades (JAK2/STAT3 and PI3K/STAT3), is necessary for nicotine-induced IRAK-M expression. Nicotine 276-284 signal transducer and activator of transcription 3 Homo sapiens 132-137 24321995-8 2014 Furthermore, the impact of nicotine treatment on phosphorylation of STAT3, HIF-1alpha and CA9 expression was assessed in HT29 cells. Nicotine 27-35 signal transducer and activator of transcription 3 Homo sapiens 68-73 21606497-1 2011 Nicotine inhibits the release of TNF-alpha from macrophage through activation of STAT3. Nicotine 0-8 signal transducer and activator of transcription 3 Homo sapiens 81-86 21606497-4 2011 Nicotine induced activation of STAT3 enhanced STAT3 binding to the TTP promoter, increased TTP promoter activity, and increased TTP expression resulting in the suppression of LPS-stimulated TNF-alpha production. Nicotine 0-8 signal transducer and activator of transcription 3 Homo sapiens 31-36 21606497-4 2011 Nicotine induced activation of STAT3 enhanced STAT3 binding to the TTP promoter, increased TTP promoter activity, and increased TTP expression resulting in the suppression of LPS-stimulated TNF-alpha production. Nicotine 0-8 signal transducer and activator of transcription 3 Homo sapiens 46-51 21606497-5 2011 Overexpression of a dominant negative mutant of STAT3 (R382W) or down-regulation of STAT3 by siRNA abolished nicotine-induced TTP expression and suppression of LPS-stimulated TNF-alpha production. Nicotine 109-117 signal transducer and activator of transcription 3 Homo sapiens 48-53 21606497-5 2011 Overexpression of a dominant negative mutant of STAT3 (R382W) or down-regulation of STAT3 by siRNA abolished nicotine-induced TTP expression and suppression of LPS-stimulated TNF-alpha production. Nicotine 109-117 signal transducer and activator of transcription 3 Homo sapiens 84-89 21606497-8 2011 In this experiment, we are reporting for the first time the involvement of TTP in the cholinergic anti-inflammatory cascade consisting of nicotine-STAT3-TTP-dampening inflammation. Nicotine 138-146 signal transducer and activator of transcription 3 Homo sapiens 147-152 24668500-0 2014 Nicotine promotes apoptosis resistance of breast cancer cells and enrichment of side population cells with cancer stem cell-like properties via a signaling cascade involving galectin-3, alpha9 nicotinic acetylcholine receptor and STAT3. Nicotine 0-8 signal transducer and activator of transcription 3 Homo sapiens 230-235 24668500-3 2014 Nicotine-induced up regulation of galectin-3 is due to an increased expression of alpha9 isoform of nicotinic acetylcholine receptor (alpha9nAChR), which activates transcription factor STAT3 that in turn, physically binds to galectin-3 (LGALS3) promoter and induces transcription of galectin-3. Nicotine 0-8 signal transducer and activator of transcription 3 Homo sapiens 185-190 24668500-5 2014 Moreover, nicotine-induced enrichment of side population cells with cancer stem cell-like properties was modulated by galectin-3 expression and could be significantly reduced by transient knock down of LGALS3 and its upstream signaling molecules STAT3 and alpha9nAChR. Nicotine 10-18 signal transducer and activator of transcription 3 Homo sapiens 246-251 24668500-6 2014 Thus, galectin-3 or its upstream signaling molecule STAT3 or alpha9nAChR could be a potential target to prevent nicotine-induced chemoresistance in breast cancer. Nicotine 112-120 signal transducer and activator of transcription 3 Homo sapiens 52-57 23717691-8 2013 Nicotine activated STAT3 in macrophages in long-term culture. Nicotine 0-8 signal transducer and activator of transcription 3 Homo sapiens 19-24 22300039-3 2012 The nonneuronal alpha7-nicotinic cholinergic receptors are a primary target for nicotine through the JAK2 and STAT3/NF-kappaB pathways, ultimately mediating the inhibition of pro-inflammatory gene transcription. Nicotine 80-88 signal transducer and activator of transcription 3 Homo sapiens 110-115 20943775-7 2011 However, the effects of nicotine on NF-kappaB activity were significantly blocked by the highly specific janus kinase 2 (JAK2) inhibitor alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG-490) and the signal transducer and activator of transcription 3 (STAT3) inhibitor 2-hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid (NSC74859). Nicotine 24-32 signal transducer and activator of transcription 3 Homo sapiens 200-250 20943775-7 2011 However, the effects of nicotine on NF-kappaB activity were significantly blocked by the highly specific janus kinase 2 (JAK2) inhibitor alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG-490) and the signal transducer and activator of transcription 3 (STAT3) inhibitor 2-hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid (NSC74859). Nicotine 24-32 signal transducer and activator of transcription 3 Homo sapiens 252-257