PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28750889-6 2017 Nicotine increased the levels of alpha5-nAChR mRNA and protein in NSCLC cell lines and activated the JAK2/STAT3 signaling cascade. Nicotine 0-8 Janus kinase 2 Homo sapiens 101-105 28750889-7 2017 Nicotine-induced activation of JAK2/STAT3 signaling was inhibited by the silencing of alpha5-nAChR. Nicotine 0-8 Janus kinase 2 Homo sapiens 31-35 25565665-7 2015 HIF-2alpha inhibitor and HIF-2alpha siRNA inhibited the effects of nicotine and LPS on the activation of Akt, JAK2 and STAT3, ERK and JNK MAPK, nuclear factor-kappaB, c-Jun, and c-Fos. Nicotine 67-75 Janus kinase 2 Homo sapiens 110-114 25259522-2 2014 A signaling pathway downstream from the alpha7 nAChRs, which involves the collaboration of JAK2/STAT3 and NF-kappaB to interfere with signaling by Toll-like receptors (TLRs), has been implicated in this anti-inflammatory effect of nicotine. Nicotine 231-239 Janus kinase 2 Homo sapiens 91-95 25259522-5 2014 By using selective inhibitors of different signaling molecules downstream from the receptor, we provide evidence that activation of STAT3, via either JAK2 and/or PI3K, through a single (JAK2/PI3K/STAT3) or two convergent cascades (JAK2/STAT3 and PI3K/STAT3), is necessary for nicotine-induced IRAK-M expression. Nicotine 276-284 Janus kinase 2 Homo sapiens 150-154 22300039-3 2012 The nonneuronal alpha7-nicotinic cholinergic receptors are a primary target for nicotine through the JAK2 and STAT3/NF-kappaB pathways, ultimately mediating the inhibition of pro-inflammatory gene transcription. Nicotine 80-88 Janus kinase 2 Homo sapiens 101-105 20943775-7 2011 However, the effects of nicotine on NF-kappaB activity were significantly blocked by the highly specific janus kinase 2 (JAK2) inhibitor alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG-490) and the signal transducer and activator of transcription 3 (STAT3) inhibitor 2-hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid (NSC74859). Nicotine 24-32 Janus kinase 2 Homo sapiens 105-119 20943775-7 2011 However, the effects of nicotine on NF-kappaB activity were significantly blocked by the highly specific janus kinase 2 (JAK2) inhibitor alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG-490) and the signal transducer and activator of transcription 3 (STAT3) inhibitor 2-hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid (NSC74859). Nicotine 24-32 Janus kinase 2 Homo sapiens 121-125 19741199-5 2009 Treatment of macrovascular human umbilical vein endothelial cells (HUVECs) and microvascular endothelial cells (MVECs) with the cholinergic agonists nicotine and GTS-21 significantly reduced IL-6-mediated monocyte chemoattractant protein-1 (MCP-1) production and ICAM-1 expression which are regulated through the JAK2/STAT3 pathway. Nicotine 149-157 Janus kinase 2 Homo sapiens 313-317 12244045-2 2002 In this study we provide evidence that nicotine stimulation of alpha7 nAChR transduces signals to phosphatidylinositol 3-kinase and Akt via Janus kinase 2 (JAK2) in a cascade, which results in neuroprotection. Nicotine 39-47 Janus kinase 2 Homo sapiens 140-154 12244045-2 2002 In this study we provide evidence that nicotine stimulation of alpha7 nAChR transduces signals to phosphatidylinositol 3-kinase and Akt via Janus kinase 2 (JAK2) in a cascade, which results in neuroprotection. Nicotine 39-47 Janus kinase 2 Homo sapiens 156-160 12244045-4 2002 This cascade is inhibited by nicotine through JAK2 activation, and these effects are blocked by preincubation with the JAK2-specific inhibitor AG-490. Nicotine 29-37 Janus kinase 2 Homo sapiens 46-50 12244045-4 2002 This cascade is inhibited by nicotine through JAK2 activation, and these effects are blocked by preincubation with the JAK2-specific inhibitor AG-490. Nicotine 29-37 Janus kinase 2 Homo sapiens 119-123 12244045-5 2002 We also found that pretreatment of cells with angiotensin II blocks the nicotine-induced activation of JAK2 via the AT(2) receptor and completely prevents alpha7 nAChR-mediated neuroprotective effects further suggesting a pivotal role for JAK2. Nicotine 72-80 Janus kinase 2 Homo sapiens 103-107 12244045-5 2002 We also found that pretreatment of cells with angiotensin II blocks the nicotine-induced activation of JAK2 via the AT(2) receptor and completely prevents alpha7 nAChR-mediated neuroprotective effects further suggesting a pivotal role for JAK2. Nicotine 72-80 Janus kinase 2 Homo sapiens 239-243 34302119-0 2021 Correction: Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling. Nicotine 68-76 Janus kinase 2 Homo sapiens 132-136 35111269-0 2022 The Natural Compound Dehydrocrenatidine Attenuates Nicotine-Induced Stemness and Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma by Regulating a7nAChR-Jak2 Signaling Pathways. Nicotine 51-59 Janus kinase 2 Homo sapiens 165-169 35111269-8 2022 Result: We found that nicotine exposure stimulated the HCC tumorigenicity by inducing the expression of one of the key nAChRs subunit that is alpha7nAChR as well as the expression of Janus kinase (JAK)-2. Nicotine 22-30 Janus kinase 2 Homo sapiens 183-203 35111269-13 2022 Thus, these findings suggest the nicotine effect on HCC progression via alpha7nAChR-mediated JAK2 signaling pathways, and DHCT treatment enhances the therapeutic potential of HCC patients via overcoming/reversing the effect of nicotine in HCC patients. Nicotine 33-41 Janus kinase 2 Homo sapiens 93-97 33603170-0 2021 Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling. Nicotine 56-64 Janus kinase 2 Homo sapiens 120-124 33603170-3 2021 Here we report that nicotine enhances ESCC cancer malignancy and tumor-initiating capacity by interacting with cholinergic receptor nicotinic alpha 7 subunit (CHRNA7) and subsequently activating the JAK2/STAT3 signaling pathway. Nicotine 20-28 Janus kinase 2 Homo sapiens 199-203 31953160-0 2020 Nicotine promotes activation of human pancreatic stellate cells through inducing autophagy via alpha7nAChR-mediated JAK2/STAT3 signaling pathway. Nicotine 0-8 Janus kinase 2 Homo sapiens 116-120 31953160-10 2020 Moreover, the alpha7nAChR-mediated JAK2/STAT3 signaling pathway was activated by nicotine, this pathway and effects of nicotine can be blocked by alpha-BTX. Nicotine 81-89 Janus kinase 2 Homo sapiens 35-39 31953160-10 2020 Moreover, the alpha7nAChR-mediated JAK2/STAT3 signaling pathway was activated by nicotine, this pathway and effects of nicotine can be blocked by alpha-BTX. Nicotine 119-127 Janus kinase 2 Homo sapiens 35-39 31953160-11 2020 SIGNIFICANCE: Our finding suggests that nicotine can promote activation of human pancreatic stellate cells (hPSCs) through inducing autophagy via alpha7nAChR-mediated JAK2/STAT3 signaling pathway, providing a new insight into the mechanisms by which nicotine affects pancreatic fibrosis. Nicotine 40-48 Janus kinase 2 Homo sapiens 167-171