PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14722323-2	2004	Nicotine interaction with the alpha7 nAChR inhibits Abeta (1-42) interaction with the same receptor, and the Abeta (1-42)-induced apoptosis is prevented through nicotine-induced activation of JAK2.	Nicotine	0-8	Janus kinase 2	Rattus norvegicus	192-196	
34153408-0	2021	Nicotine facilitates pancreatic fibrosis by promoting activation of pancreatic stellate cells via alpha7nAChR-mediated JAK2/STAT3 signaling pathway in rats.	Nicotine	0-8	Janus kinase 2	Rattus norvegicus	119-123	
34153408-13	2021	Moreover, nicotine also activated the alpha7nAChR-mediated JAK2/STAT3 signaling pathway in rPSCs.	Nicotine	10-18	Janus kinase 2	Rattus norvegicus	59-63	
34153408-15	2021	SIGNIFICANCE: Our finding in this research suggests that nicotine facilitates pancreatic fibrosis by promoting activation of pancreatic stellate cells via alpha7nAChR-mediated JAK2/STAT3 signaling pathway in rats, partly revealing the mechanism of smoking on chronic pancreatitis.	Nicotine	57-65	Janus kinase 2	Rattus norvegicus	176-180	
19063868-1	2009	Our laboratories have previously identified the alpha7 nAChR-JAK2 pathway as playing a central role in nicotine-induced neuroprotection.	Nicotine	103-111	Janus kinase 2	Rattus norvegicus	61-65	
19063868-3	2009	In this study, we investigated the effects of inhibiting the alpha7 nAChR-JAK2 pro-survival cascade on the nicotine-induced production of the survival factor Bcl-2 and the transcriptional activation of NF-kappaB, AP-1, STAT1, STAT3, and STAT5.	Nicotine	107-115	Janus kinase 2	Rattus norvegicus	74-78	
19063868-4	2009	We report that nicotine induced the production of Bcl-2 and increased the transcriptional activation of NF-kappaB, AP-1, STAT1, and STAT3, and with the exception of AP-1, the other transcription factors (NF-kappaB, STAT1, and STAT3) were significantly reduced by JAK2 inhibition.	Nicotine	15-23	Janus kinase 2	Rattus norvegicus	263-267	
14722323-1	2004	We have recently provided evidence for nicotine-induced complex formation between the alpha7 nicotinic acetylcholine receptor (nAChR) and the tyrosine-phosphorylated enzyme Janus kinase 2 (JAK2) that results in subsequent activation of phosphatidylinositol-3-kinase (PI-3-K) and Akt.	Nicotine	39-47	Janus kinase 2	Rattus norvegicus	173-187	
14722323-1	2004	We have recently provided evidence for nicotine-induced complex formation between the alpha7 nicotinic acetylcholine receptor (nAChR) and the tyrosine-phosphorylated enzyme Janus kinase 2 (JAK2) that results in subsequent activation of phosphatidylinositol-3-kinase (PI-3-K) and Akt.	Nicotine	39-47	Janus kinase 2	Rattus norvegicus	189-193	
14722323-2	2004	Nicotine interaction with the alpha7 nAChR inhibits Abeta (1-42) interaction with the same receptor, and the Abeta (1-42)-induced apoptosis is prevented through nicotine-induced activation of JAK2.	Nicotine	161-169	Janus kinase 2	Rattus norvegicus	192-196	
14657181-1	2003	We showed recently that nicotine activates the growth-promoting enzyme Janus kinase 2 (JAK2) in PC12 cells and that preincubation of these cells with the JAK2-specific inhibitor AG-490 blocked the nicotine-induced neuroprotection against beta-amyloid (1-42) [Abeta (1-42)].	Nicotine	24-32	Janus kinase 2	Rattus norvegicus	71-85	
14657181-1	2003	We showed recently that nicotine activates the growth-promoting enzyme Janus kinase 2 (JAK2) in PC12 cells and that preincubation of these cells with the JAK2-specific inhibitor AG-490 blocked the nicotine-induced neuroprotection against beta-amyloid (1-42) [Abeta (1-42)].	Nicotine	24-32	Janus kinase 2	Rattus norvegicus	87-91	
14657181-1	2003	We showed recently that nicotine activates the growth-promoting enzyme Janus kinase 2 (JAK2) in PC12 cells and that preincubation of these cells with the JAK2-specific inhibitor AG-490 blocked the nicotine-induced neuroprotection against beta-amyloid (1-42) [Abeta (1-42)].	Nicotine	24-32	Janus kinase 2	Rattus norvegicus	154-158	
14657181-1	2003	We showed recently that nicotine activates the growth-promoting enzyme Janus kinase 2 (JAK2) in PC12 cells and that preincubation of these cells with the JAK2-specific inhibitor AG-490 blocked the nicotine-induced neuroprotection against beta-amyloid (1-42) [Abeta (1-42)].	Nicotine	197-205	Janus kinase 2	Rattus norvegicus	71-85	
14657181-1	2003	We showed recently that nicotine activates the growth-promoting enzyme Janus kinase 2 (JAK2) in PC12 cells and that preincubation of these cells with the JAK2-specific inhibitor AG-490 blocked the nicotine-induced neuroprotection against beta-amyloid (1-42) [Abeta (1-42)].	Nicotine	197-205	Janus kinase 2	Rattus norvegicus	87-91	
14657181-1	2003	We showed recently that nicotine activates the growth-promoting enzyme Janus kinase 2 (JAK2) in PC12 cells and that preincubation of these cells with the JAK2-specific inhibitor AG-490 blocked the nicotine-induced neuroprotection against beta-amyloid (1-42) [Abeta (1-42)].	Nicotine	197-205	Janus kinase 2	Rattus norvegicus	154-158	
14657181-3	2003	We also showed that preincubation with angiotensin II (Ang II), functioning via the angiotensin II type 2 (AT2) receptor, blocked both the nicotine-induced activation of JAK2 and its neuroprotection against Abeta (1-42).	Nicotine	139-147	Janus kinase 2	Rattus norvegicus	170-174	
14657181-5	2003	Therefore, the potential biological significance of AT2 receptor-induced effects on both the nicotine-induced activation of JAK2 and its neuroprotection against Abeta (1-42) led us to investigate whether SHP-1 activation could be involved in this process.	Nicotine	93-101	Janus kinase 2	Rattus norvegicus	124-128	
14657181-6	2003	We found that Ang II induced the activation of SHP-1 and that an antisense against SHP-1 not only augmented the nicotine-induced tyrosine phosphorylation of JAK2 but also blocked the Ang II neutralization of the nicotine-induced neuroprotection.	Nicotine	112-120	Janus kinase 2	Rattus norvegicus	157-161	
14657181-6	2003	We found that Ang II induced the activation of SHP-1 and that an antisense against SHP-1 not only augmented the nicotine-induced tyrosine phosphorylation of JAK2 but also blocked the Ang II neutralization of the nicotine-induced neuroprotection.	Nicotine	212-220	Janus kinase 2	Rattus norvegicus	157-161	
14657181-7	2003	These results demonstrate that nicotine-induced tyrosine phosphorylation of JAK2 and neuroprotection against Abeta (1-42) in PC12 cells are blocked by Ang II via AT2 receptor-induced activation of SHP-1.	Nicotine	31-39	Janus kinase 2	Rattus norvegicus	76-80