PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34333049-17	2021	Both nicotine and celecoxib can inhibit inflammation, but through different mechanisms: nicotine can activate alpha4beta2-nAChRs while celecoxib is cyclooxygenase-2 inhibitor.	Nicotine	5-13	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	148-164	
28944930-8	2017	Treatment with nicotine decreased AP and osteocalcin levels, increased TNF-alpha and COX-2 expression levels, and led to alveolar bone loss compared with the control group.	Nicotine	15-23	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	85-90	
19673871-11	2009	I/R treatment increased mRNA levels of COX-2, IL-1beta, IL-6 and iNOS, which were further augmented by nicotine in a dose-dependent manner.	Nicotine	103-111	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	39-44	
28691127-10	2017	The mRNA gene expression of inducible cyclooxygenase-2 gene was highly increased with nicotine intoxication while that of cyclooxygenase-1 did not show any changes.	Nicotine	86-94	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	38-54	
19673871-12	2009	Correspondingly, nicotine (0.35 mg kg(-1) daily) markedly enhanced the protein expression of COX-2 and iNOS.	Nicotine	17-25	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	93-98	
11811354-5	2001	Cyclooxygenase-1 (COX-1) inhibitors (flurbiprofen, ketoprofen and ketrolack) attenuated the nicotine-induced contraction in a concentration-dependent manner, and cyclooxygenase-2 (COX-2) inhibitors at high concentrations (nimesulide and NS-389) slightly attenuated the contraction.	Nicotine	92-100	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	180-185	
18351285-0	2008	Immunohistochemical increase in cyclooxygenase-2 without apoptosis in different brain areas of subchronic nicotine- and D-amphetamine-treated rats.	Nicotine	106-114	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	32-48	
18351285-2	2008	To clarify whether nicotine-induced upregulation of COX-2 occurs, and to analyse its significance, a comparative immunohistochemical and Western blot study was performed on the frontoparietal cortex, hippocampus and cerebellar cortex of rats treated (14 days) with nicotine, D(+)amphetamine (0.35 and 1.16 mg free base/kg/day, respectively), or both drugs simultaneously.	Nicotine	19-27	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	52-57	
18351285-7	2008	Western blot analysis revealed a 50-80% increase in COX-2 in the brain cortex and hippocampus of nicotine-treated rats, and similar increases (150-200%) in the cortex of the D(+)amphetamine- and nicotine + D(+)amphetamine-treated rats.	Nicotine	97-105	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	52-57	
18351285-8	2008	Nicotine-induced upregulation of COX-2 seems to be related to neuronal plasticity rather than neurodegeneration.	Nicotine	0-8	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	33-38	
18068289-8	2008	Our Western blot analysis showed a significant increase in the expression of cyclooxygenase-2 and NF-kappaB in lung and liver of nicotine-treated rats.	Nicotine	129-137	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	77-93	
15670336-0	2005	Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures.	Nicotine	57-65	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	91-107	
15670336-10	2005	By contrast, nicotine enhances the expression of cyclooxygenase-2 and the synthesis of one of its major products, prostaglandin E2.	Nicotine	13-21	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	49-65